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ONTOLOGY REPORT - ANNOTATIONS


Term:necroptotic process
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Accession:GO:0070266 term browser browse the term
Definition:A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
Comment:Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.
Synonyms:exact_synonym: RIPK1-mediated regulated necrosis
 narrow_synonym: TNF-induced necroptosis;   necroptosis
 broad_synonym: induction of necroptosis;   induction of necroptosis by extracellular signals;   induction of necroptosis of activated-T cells;   programmed necrosis;   programmed necrotic cell death
 related_synonym: PARP-dependent cell death;   activation of necroptosis;   activation of necroptosis by extracellular signals;   activation of necroptosis in response to extracellular signals;   activation of necroptosis of activated-T cells;   establishment of necroptosis;   establishment of necroptosis of activated-T cells;   extracellular signal-induced necroptosis;   parthanatos
 alt_id: GO:0060553;   GO:0060554;   GO:0060555


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necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:104798|MGI:108212|MGI:1261423|MGI:2154952 (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5824599|PMID:27545878)
RGD PMID:21052097 PMID:22037414 PMID:27545878, PMID:21873635 MGI:5306844 MGI:5315337 MGI:5824599, RGD:13792537 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Dnm1l dynamin 1-like involved_in ISS
ISO
GO_REF:0000024
(MGI:5516181|PMID:22265414)
(PMID:22265414)
UniProt
RGD
PMID:22265414 GO_REF:0000024 MGI:5516181 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Faslg Fas ligand involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Ipmk inositol polyphosphate multikinase involved_in ISO
ISS
(PMID:29883610)
GO_REF:0000024
RGD
UniProt
PMID:29883610 GO_REF:0000024 NCBI chr20:18,457,309...18,489,884
Ensembl chr20:18,457,310...18,489,833
JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase involved_in ISO (PMID:29883610) RGD PMID:29883610 NCBI chr 6:126,448,920...126,582,188
Ensembl chr 6:126,450,139...126,582,134
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO
ISS
(PMID:22265414), (PMID:24316671), (PMID:29883610)
(MGI:5532892|PMID:24012422), (MGI:5532894|PMID:23835476)
GO_REF:0000024
RGD
UniProt
PMID:22265414 PMID:23835476 PMID:24012422 PMID:24316671 PMID:29883610 GO_REF:0000024 MGI:5532892 MGI:5532894 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851
JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 acts_upstream_of_or_within ISO (MGI:6453663|PMID:30248149) RGD PMID:30248149 MGI:6453663 NCBI chr 1:213,676,954...213,683,114
Ensembl chr 1:213,686,046...213,691,943
JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase involved_in ISO
IEA
ISS
(PMID:22265414)
(MGI:5516181|PMID:22265414)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:22265414 GO_REF:0000024 GO_REF:0000107 MGI:5516181 NCBI chr12:52,467,417...52,474,533
Ensembl chr12:52,467,450...52,474,511
JBrowse link
G Ppif peptidylprolyl isomerase F acts_upstream_of_or_within ISO MGI:98834 (MGI:5431269|PMID:22726440) RGD PMID:22726440 MGI:5431269 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Pygl glycogen phosphorylase L acts_upstream_of_or_within ISO MGI:2154952 (MGI:5510543|PMID:19498109) RGD PMID:19498109 MGI:5510543 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:104798|MGI:1921506|MGI:2154952|MGI:95484 (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5510543|PMID:19498109)
(MGI:5912943|PMID:28701375), (MGI:5926457|PMID:28842570), (MGI:6120592|PMID:29440439), (MGI:6362112|PMID:31519886), (MGI:6362574|PMID:31519887), (MGI:6369186|PMID:30867408)
(PMID:21737330), (PMID:22265414), (PMID:29440439)
UniProt
RGD
PMID:19498109 PMID:21052097 PMID:21737330 PMID:22037414 PMID:22265414 PMID:28701375 PMID:28842570 PMID:29440439 PMID:30867408 PMID:31519886 PMID:31519887 GO_REF:0000024 MGI:5306844 MGI:5315337 MGI:5510543 MGI:5912943 MGI:5926457 MGI:6120592 MGI:6362112 MGI:6362574 MGI:6369186 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(MGI:5532892|PMID:24012422)
MGI:104798|MGI:108212|MGI:109324|MGI:1261423|MGI:1336166|MGI:1921506 (MGI:4947443|PMID:21368763), (MGI:5294742|PMID:21402742), (MGI:5306844|PMID:22037414), (MGI:5486419|PMID:22675671), (MGI:5510543|PMID:19498109)
(PMID:21737330), (PMID:29883609)
UniProt
RGD
PMID:19498109 PMID:21368763 PMID:21402742 PMID:21737330 PMID:22037414 PMID:22675671 PMID:24012422 PMID:29883609 GO_REF:0000024 MGI:4947443 MGI:5294742 MGI:5306844 MGI:5486419 MGI:5510543 MGI:5532892 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Spata2 spermatogenesis associated 2 acts_upstream_of ISO (MGI:5824599|PMID:27545878) RGD PMID:27545878 MGI:5824599 NCBI chr 3:164,229,211...164,239,483
Ensembl chr 3:164,230,852...164,239,250
JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:2145814 (MGI:5431269|PMID:22726440) RGD PMID:22726440 MGI:5431269 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:24316671)
UniProt
Ensembl
RGD
PMID:24316671 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:119,258,189...119,347,084
Ensembl chr 3:119,259,467...119,330,345
JBrowse link
execution phase of necroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO (MGI:6434626|PMID:32296175), (MGI:6436412|PMID:32200799), (MGI:6436434|PMID:27321907) RGD PMID:27321907 PMID:32200799 PMID:32296175 MGI:6434626 MGI:6436412 MGI:6436434 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:6436445|PMID:27746097), (MGI:6442612|PMID:27917412)
UniProt
RGD
PMID:27746097 PMID:27917412 GO_REF:0000024 MGI:6436445 MGI:6442612 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
necroptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fas Fas cell surface death receptor involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:16507998)
MGI:108212 (MGI:5315337|PMID:21052097)
PMID:21873635
RGD PMID:16507998 PMID:21052097, PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO (PMID:22265413)
(MGI:5516182|PMID:22265413)
RGD PMID:22265413 MGI:5516182 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5291865|PMID:21876153), (MGI:6401044|PMID:31827281)
(PMID:11101870), (PMID:16507998), (PMID:22265413), (PMID:22817896), (PMID:31827280)
UniProt
RGD
PMID:11101870 PMID:16507998 PMID:21876153 PMID:22265413 PMID:22817896 PMID:31827280 PMID:31827281 GO_REF:0000024 MGI:5291865 MGI:6401044 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO (PMID:22265413), (PMID:22817896) RGD PMID:22265413 PMID:22817896 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Tlr3 toll-like receptor 3 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tnf tumor necrosis factor involved_in
acts_upstream_of_or_within
ISO
ISS
(PMID:11101870), (PMID:22265413), (PMID:22265414), (PMID:22817896)
MGI:108212|MGI:1197009|MGI:1261423|MGI:1336166|MGI:1346877|MGI:1921506|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5510543|PMID:19498109)
GO_REF:0000024
RGD
UniProt
PMID:11101870 PMID:19498109 PMID:21052097 PMID:21368763 PMID:22037414 PMID:22265413 PMID:22265414 PMID:22817896 GO_REF:0000024 MGI:4947443 MGI:5306844 MGI:5315337 MGI:5510543 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
negative regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:22711822) RGD PMID:22711822 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:104798 (MGI:5315337|PMID:21052097)
RGD PMID:21052097, PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in IBA
ISO
PMID:21873635
(MGI:5315337|PMID:21052097)
RGD PMID:21052097, PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:5796062 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Casp8 caspase 8 involved_in
acts_upstream_of_or_within
ISO
ISS
(PMID:31827280)
MGI:104798|MGI:1336166|MGI:1921506|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5294742|PMID:21402742), (MGI:5306844|PMID:22037414), (MGI:5521568|PMID:22089168)
(MGI:6378798|PMID:31511692), (MGI:6401035|PMID:31748744), (MGI:6401044|PMID:31827281)
GO_REF:0000024
RGD
UniProt
PMID:21368763 PMID:21402742 PMID:22037414 PMID:22089168 PMID:31511692 PMID:31748744 PMID:31827280 PMID:31827281 GO_REF:0000024 MGI:4947443 MGI:5294742 MGI:5306844 MGI:5521568 MGI:6378798 MGI:6401035 MGI:6401044 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cav1 caveolin 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5464050|PMID:23049990)
Ensembl
RGD
PMID:23049990 GO_REF:0000107 MGI:5464050 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator acts_upstream_of_or_within ISO MGI:104798|MGI:1261423|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168) RGD PMID:21368763 PMID:22089168 PMID:22675671 MGI:4947443 MGI:5486419 MGI:5521568 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Fadd Fas associated via death domain acts_upstream_of_or_within ISO MGI:104798|MGI:2154952 (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168) RGD PMID:22089168 PMID:22675671 MGI:5486419 MGI:5521568 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
Ensembl chr 9:47,186,558...47,244,416
JBrowse link
G Mutyh mutY DNA glycosylase involved_in IEA
ISO
GO_REF:0000107
(MGI:6378777|PMID:28059467)
Ensembl
RGD
PMID:28059467 GO_REF:0000107 MGI:6378777 NCBI chr 5:135,663,328...135,675,348
Ensembl chr 5:135,663,371...135,675,344
JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 involved_in ISO (PMID:29883609)
(MGI:6163945|PMID:29883609)
RGD PMID:29883609 MGI:6163945 NCBI chr14:106,008,086...106,062,566
Ensembl chr14:106,008,086...106,061,641
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104798 (MGI:5521568|PMID:22089168)
Ensembl
RGD
PMID:22089168 GO_REF:0000107 MGI:5521568 NCBI chr 3:147,793,014...147,809,941
Ensembl chr 3:147,793,017...147,809,919
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (MGI:5602910|PMID:24813850), (MGI:5602911|PMID:24813849), (MGI:5907398|PMID:27819682), (MGI:5907399|PMID:27819681) RGD PMID:24813849 PMID:24813850 PMID:27819681 PMID:27819682 MGI:5602910 MGI:5602911 MGI:5907398 MGI:5907399 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Rnf31 ring finger protein 31 acts_upstream_of_or_within ISO MGI:104798 (MGI:5521568|PMID:22089168) RGD PMID:22089168 MGI:5521568 NCBI chr15:34,270,037...34,282,385
Ensembl chr15:34,270,648...34,282,495
JBrowse link
G Slc25a4 solute carrier family 25 member 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:16507998)
Ensembl
RGD
PMID:16507998 GO_REF:0000107 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Ybx3 Y box binding protein 3 involved_in IEA
ISO
GO_REF:0000107
(PMID:22711822)
Ensembl
RGD
PMID:22711822 GO_REF:0000107 NCBI chr 4:165,606,819...165,630,041
Ensembl chr 4:165,606,819...165,630,118
JBrowse link
negative regulation of ripoptosome assembly involved in necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 acts_upstream_of_or_within ISO MGI:104798|MGI:108212 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 acts_upstream_of_or_within ISO MGI:104798|MGI:108212 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
Ensembl chr 9:47,186,558...47,244,416
JBrowse link
positive regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gzmb granzyme B IMP RGD PMID:19895873 RGD:2325193 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in IMP
ISO
(PMID:22028622), (PMID:22274400), (PMID:22817896) RGD PMID:22028622 PMID:22274400 PMID:22817896, PMID:22372834 RGD:7777172 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO
ISS
(PMID:22265414), (PMID:22817896)
(MGI:5315337|PMID:21052097), (MGI:5516181|PMID:22265414), (MGI:5602910|PMID:24813850), (MGI:5602911|PMID:24813849), (MGI:6434626|PMID:32296175), (MGI:6436371|PMID:22423968), (MGI:6436412|PMID:32200799), (MGI:6436434|PMID:27321907)
GO_REF:0000024
RGD
UniProt
PMID:21052097 PMID:22265414 PMID:22423968 PMID:22817896 PMID:24813849 PMID:24813850 PMID:27321907 PMID:32200799 PMID:32296175 GO_REF:0000024 MGI:5315337 MGI:5516181 MGI:5602910 MGI:5602911 MGI:6434626 MGI:6436371 MGI:6436412 MGI:6436434 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in ISO
ISS
(PMID:32200799)
(MGI:5907398|PMID:27819682), (MGI:5907399|PMID:27819681), (MGI:6095612|PMID:29073079), (MGI:6434626|PMID:32296175), (MGI:6436371|PMID:22423968), (MGI:6436393|PMID:30050136), (MGI:6436412|PMID:32200799), (MGI:6436445|PMID:27746097), (MGI:6442612|PMID:27917412)
GO_REF:0000024
RGD
UniProt
PMID:22423968 PMID:27746097 PMID:27819681 PMID:27819682 PMID:27917412 PMID:29073079 PMID:30050136 PMID:32200799 PMID:32296175 GO_REF:0000024 MGI:5907398 MGI:5907399 MGI:6095612 MGI:6434626 MGI:6436371 MGI:6436393 MGI:6436412 MGI:6436445 MGI:6442612 NCBI chr 3:171,276,062...171,292,062
Ensembl chr 3:171,276,062...171,286,537
JBrowse link
regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in IEA
ISO
GO_REF:0000107
(MGI:5912943|PMID:28701375)
(PMID:27458237)
Ensembl
RGD
PMID:27458237 PMID:28701375 GO_REF:0000107 MGI:5912943 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Fadd Fas associated via death domain IMP RGD PMID:26038570 RGD:11341801 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Spata2 spermatogenesis associated 2 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:5912943|PMID:28701375)
PMID:21873635
(PMID:27307491), (PMID:27458237), (PMID:27545878)
UniProt
RGD
PMID:27307491 PMID:27458237 PMID:27545878 PMID:28701375, PMID:21873635 GO_REF:0000024 MGI:5912943, RGD:13792537 NCBI chr 3:164,229,211...164,239,483
Ensembl chr 3:164,230,852...164,239,250
JBrowse link
ripoptosome assembly involved in necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (MGI:5306844|PMID:22037414) RGD PMID:22037414 MGI:5306844 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 acts_upstream_of_or_within ISO MGI:104798|MGI:1197009|MGI:1346877 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    cellular process 18481
      cell death 2129
        necrotic cell death 62
          programmed necrotic cell death 45
            necroptotic process 35
              execution phase of necroptosis 2
              necroptotic signaling pathway 8
              negative regulation of necroptotic process 16
              positive regulation of necroptotic process 4
              regulation of necroptotic process + 21
              ripoptosome assembly involved in necroptotic process + 4
paths to the root