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ONTOLOGY REPORT - ANNOTATIONS

Term:necrotic cell death
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Accession:GO:0070265 term browser browse the term
Definition:A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
Comment:Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.
Synonyms:exact_synonym: cellular necrosis
 broad_synonym: necrosis


show annotations for term's descendants           Sort by:
 
necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsdme gasdermin E involved_in ISO
IBA		 (PMID:28045099)
PMID:21873635
(MGI:5901785|PMID:28045099)		 RGD PMID:28045099 PMID:21873635 MGI:5901785, RGD:13792537 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806 		JBrowse link
G Ninj1 ninjurin 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6694344|PMID:33472215)
(PMID:33472215)		 UniProt
RGD		 PMID:33472215 GO_REF:0000024 MGI:6694344 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704 		JBrowse link
G Oga O-GlcNAcase IMP RGD PMID:16899550 RGD:2305957 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359 		JBrowse link
execution phase of necroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO (MGI:6434626|PMID:32296175), (MGI:6436412|PMID:32200799), (MGI:6436434|PMID:27321907) RGD PMID:27321907 PMID:32200799 PMID:32296175 MGI:6434626 MGI:6436412 MGI:6436434 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6436445|PMID:27746097), (MGI:6442612|PMID:27917412)		 UniProt
RGD		 PMID:27746097 PMID:27917412 GO_REF:0000024 MGI:6436445 MGI:6442612 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:104798|MGI:108212|MGI:1261423|MGI:2154952 (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5824599|PMID:27545878)		 RGD PMID:21052097 PMID:22037414 PMID:27545878 PMID:21873635 MGI:5306844 MGI:5315337 MGI:5824599, RGD:13792537 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Dnm1l dynamin 1-like involved_in ISS
ISO		 GO_REF:0000024
(MGI:5516181|PMID:22265414)
(PMID:22265414)		 UniProt
RGD		 PMID:22265414 GO_REF:0000024 MGI:5516181 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Faslg Fas ligand involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Ipmk inositol polyphosphate multikinase involved_in ISO
ISS		 (PMID:29883610)
GO_REF:0000024		 RGD
UniProt		 PMID:29883610 GO_REF:0000024 NCBI chr20:17,216,988...17,251,675
Ensembl chr20:17,218,037...17,251,705 		JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase involved_in ISO (PMID:29883610) RGD PMID:29883610 NCBI chr 6:121,710,750...121,844,501
Ensembl chr 6:121,710,755...121,844,107 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO
ISS		 (PMID:22265414), (PMID:24316671), (PMID:29883610)
(MGI:5532892|PMID:24012422), (MGI:5532894|PMID:23835476)
GO_REF:0000024		 RGD
UniProt		 PMID:22265414 PMID:23835476 PMID:24012422 PMID:24316671 PMID:29883610 GO_REF:0000024 MGI:5532892 MGI:5532894 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:6453663|PMID:30248149)
GO_REF:0000107		 RGD
Ensembl		 PMID:30248149 GO_REF:0000107 MGI:6453663 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113 		JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase involved_in ISO
IEA
ISS		 (PMID:22265414)
(MGI:5516181|PMID:22265414)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:22265414 GO_REF:0000024 GO_REF:0000107 MGI:5516181 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420 		JBrowse link
G Ppif peptidylprolyl isomerase F acts_upstream_of_or_within ISO MGI:98834 (MGI:5431269|PMID:22726440) RGD PMID:22726440 MGI:5431269 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Pygl glycogen phosphorylase L acts_upstream_of_or_within ISO MGI:2154952 (MGI:5510543|PMID:19498109) RGD PMID:19498109 MGI:5510543 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:104798|MGI:1921506|MGI:2154952|MGI:95484 (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5510543|PMID:19498109)
(MGI:5912943|PMID:28701375), (MGI:5926457|PMID:28842570), (MGI:6120592|PMID:29440439), (MGI:6362112|PMID:31519886), (MGI:6362574|PMID:31519887), (MGI:6369186|PMID:30867408)
(PMID:21737330), (PMID:22265414), (PMID:29440439)		 UniProt
RGD		 PMID:19498109 PMID:21052097 PMID:21737330 PMID:22037414 PMID:22265414 More... GO_REF:0000024 MGI:5306844 MGI:5315337 MGI:5510543 MGI:5912943 MGI:5926457 MGI:6120592 MGI:6362112 MGI:6362574 MGI:6369186 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(MGI:5532892|PMID:24012422)
MGI:104798|MGI:108212|MGI:109324|MGI:1261423|MGI:1336166|MGI:1921506 (MGI:4947443|PMID:21368763), (MGI:5294742|PMID:21402742), (MGI:5306844|PMID:22037414), (MGI:5486419|PMID:22675671), (MGI:5510543|PMID:19498109)
(PMID:21737330), (PMID:29883609)		 UniProt
RGD		 PMID:19498109 PMID:21368763 PMID:21402742 PMID:21737330 PMID:22037414 More... GO_REF:0000024 MGI:4947443 MGI:5294742 MGI:5306844 MGI:5486419 MGI:5510543 MGI:5532892 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Spata2 spermatogenesis associated 2 acts_upstream_of ISO (MGI:5824599|PMID:27545878) RGD PMID:27545878 MGI:5824599 NCBI chr 3:156,202,962...156,213,283
Ensembl chr 3:156,202,967...156,211,705 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:2145814 (MGI:5431269|PMID:22726440) RGD PMID:22726440 MGI:5431269 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:24316671)		 UniProt
Ensembl
RGD		 PMID:24316671 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190 		JBrowse link
necroptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:16507998)
MGI:108212 (MGI:5315337|PMID:21052097)
PMID:21873635		 RGD PMID:16507998 PMID:21052097 PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO (PMID:22265413)
(MGI:5516182|PMID:22265413)		 RGD PMID:22265413 MGI:5516182 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5291865|PMID:21876153), (MGI:6401044|PMID:31827281)
(PMID:11101870), (PMID:16507998), (PMID:22265413), (PMID:22817896), (PMID:31827280)		 UniProt
RGD		 PMID:11101870 PMID:16507998 PMID:21876153 PMID:22265413 PMID:22817896 More... GO_REF:0000024 MGI:5291865 MGI:6401044 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO (PMID:22265413), (PMID:22817896) RGD PMID:22265413 PMID:22817896 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Tlr3 toll-like receptor 3 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tnf tumor necrosis factor involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:11101870), (PMID:22265413), (PMID:22265414), (PMID:22817896)
MGI:108212|MGI:1197009|MGI:1261423|MGI:1336166|MGI:1346877|MGI:1921506|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5510543|PMID:19498109)
GO_REF:0000024		 RGD
UniProt		 PMID:11101870 PMID:19498109 PMID:21052097 PMID:21368763 PMID:22037414 More... GO_REF:0000024 MGI:4947443 MGI:5306844 MGI:5315337 MGI:5510543 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
negative regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adprs ADP-ribosylserine hydrolase involved_in ISO
IEA		 (MGI:6445044|PMID:30830864)
GO_REF:0000107		 RGD
Ensembl		 PMID:30830864 GO_REF:0000107 MGI:6445044 NCBI chr 5:138,614,022...138,619,296
Ensembl chr 5:138,614,022...138,619,296 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:22711822) RGD PMID:22711822 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:104798 (MGI:5315337|PMID:21052097)		 RGD PMID:21052097 PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in IBA
ISO		 PMID:21873635
(MGI:5315337|PMID:21052097)		 RGD PMID:21052097 PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:5796062 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Casp2 caspase 2 involved_in ISO (PMID:30025878) RGD PMID:30025878 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp8 caspase 8 involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:31827280)
MGI:104798|MGI:1336166|MGI:1921506|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5294742|PMID:21402742), (MGI:5306844|PMID:22037414), (MGI:5521568|PMID:22089168)
(MGI:6378798|PMID:31511692), (MGI:6401035|PMID:31748744), (MGI:6401044|PMID:31827281)
GO_REF:0000024		 RGD
UniProt		 PMID:21368763 PMID:21402742 PMID:22037414 PMID:22089168 PMID:31511692 More... GO_REF:0000024 MGI:4947443 MGI:5294742 MGI:5306844 MGI:5521568 MGI:6378798 MGI:6401035 MGI:6401044 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cav1 caveolin 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5464050|PMID:23049990)		 Ensembl
RGD		 PMID:23049990 GO_REF:0000107 MGI:5464050 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator acts_upstream_of_or_within ISO MGI:104798|MGI:1261423|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168) RGD PMID:21368763 PMID:22089168 PMID:22675671 MGI:4947443 MGI:5486419 MGI:5521568 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Fadd Fas associated via death domain acts_upstream_of_or_within ISO MGI:104798|MGI:2154952 (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168) RGD PMID:22089168 PMID:22675671 MGI:5486419 MGI:5521568 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mutyh mutY DNA glycosylase involved_in IEA
ISO		 GO_REF:0000107
(MGI:6378777|PMID:28059467)		 Ensembl
RGD		 PMID:28059467 GO_REF:0000107 MGI:6378777 NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 involved_in ISO (PMID:29883609)
(MGI:6163945|PMID:29883609)		 RGD PMID:29883609 MGI:6163945 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:104798 (MGI:5521568|PMID:22089168)		 Ensembl
RGD		 PMID:22089168 GO_REF:0000107 MGI:5521568 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (MGI:5602910|PMID:24813850), (MGI:5602911|PMID:24813849), (MGI:5907398|PMID:27819682), (MGI:5907399|PMID:27819681) RGD PMID:24813849 PMID:24813850 PMID:27819681 PMID:27819682 MGI:5602910 MGI:5602911 MGI:5907398 MGI:5907399 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Rnf31 ring finger protein 31 acts_upstream_of_or_within ISO MGI:104798 (MGI:5521568|PMID:22089168) RGD PMID:22089168 MGI:5521568 NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16507998)		 Ensembl
RGD		 PMID:16507998 GO_REF:0000107 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Ybx3 Y box binding protein 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22711822)		 Ensembl
RGD		 PMID:22711822 GO_REF:0000107 NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161 		JBrowse link
negative regulation of necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor involved_in ISO (MGI:3794480|PMID:16443691) RGD PMID:16443691 MGI:3794480 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 IMP RGD PMID:23409069 RGD:150517731 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Fth1 ferritin heavy chain 1 IMP RGD PMID:18992754 RGD:2315110 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Mt3 metallothionein 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5315682|PMID:20371971)
(PMID:18554677)		 UniProt
RGD		 PMID:18554677 PMID:20371971 GO_REF:0000024 MGI:5315682 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 IMP RGD PMID:26888427 RGD:11040458 NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5617337|PMID:24440909)		 Ensembl
RGD		 PMID:24440909 GO_REF:0000107 MGI:5617337 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Ucn urocortin IDA RGD PMID:20933497 RGD:5508190 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950 		JBrowse link
negative regulation of programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISO
ISS		 (PMID:30451898)
GO_REF:0000024		 RGD
UniProt		 PMID:30451898 GO_REF:0000024 NCBI chr 1:181,213,292...181,215,327 JBrowse link
negative regulation of ripoptosome assembly involved in necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 acts_upstream_of_or_within ISO MGI:104798|MGI:108212 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 acts_upstream_of_or_within ISO MGI:104798|MGI:108212 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
oncosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tmem123 transmembrane protein 123 involved_in ISO
IEA		 (PMID:11481458), (PMID:9600958)
GO_REF:0000107		 RGD
Ensembl		 PMID:9600958 PMID:11481458 GO_REF:0000107 NCBI chr 8:4,922,098...4,952,228
Ensembl chr 8:4,922,098...4,952,224 		JBrowse link
positive regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp6 caspase 6 involved_in ISO
ISS		 (PMID:32298652)
GO_REF:0000024		 RGD
UniProt		 PMID:32298652 GO_REF:0000024 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Gzmb granzyme B IMP RGD PMID:19895873 RGD:2325193 NCBI chr15:30,343,361...30,346,792 JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in IMP
ISO		 (PMID:22028622), (PMID:22274400), (PMID:22817896) RGD PMID:22028622 PMID:22274400 PMID:22817896 PMID:22372834 RGD:7777172 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO
ISS		 (PMID:22265414), (PMID:22817896)
(MGI:5315337|PMID:21052097), (MGI:5516181|PMID:22265414), (MGI:5602910|PMID:24813850), (MGI:5602911|PMID:24813849), (MGI:6434626|PMID:32296175), (MGI:6436371|PMID:22423968), (MGI:6436412|PMID:32200799), (MGI:6436434|PMID:27321907)
GO_REF:0000024		 RGD
UniProt		 PMID:21052097 PMID:22265414 PMID:22423968 PMID:22817896 PMID:24813849 More... GO_REF:0000024 MGI:5315337 MGI:5516181 MGI:5602910 MGI:5602911 MGI:6434626 MGI:6436371 MGI:6436412 MGI:6436434 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in ISO
ISS		 (PMID:32200799)
(MGI:5907398|PMID:27819682), (MGI:5907399|PMID:27819681), (MGI:6095612|PMID:29073079), (MGI:6434626|PMID:32296175), (MGI:6436371|PMID:22423968), (MGI:6436393|PMID:30050136), (MGI:6436412|PMID:32200799), (MGI:6436445|PMID:27746097), (MGI:6442612|PMID:27917412), (MGI:6453154|PMID:32350114), (MGI:6490907|PMID:33109609)
GO_REF:0000024		 RGD
UniProt		 PMID:22423968 PMID:27746097 PMID:27819681 PMID:27819682 PMID:27917412 More... GO_REF:0000024 MGI:5907398 MGI:5907399 MGI:6095612 MGI:6434626 MGI:6436371 MGI:6436393 MGI:6436412 MGI:6436445 MGI:6442612 MGI:6453154 MGI:6490907 NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870 		JBrowse link
positive regulation of necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg9a autophagy related 9A involved_in ISO (MGI:5906103|PMID:27811852) RGD PMID:27811852 MGI:5906103 NCBI chr 9:76,677,403...76,688,035
Ensembl chr 9:76,677,404...76,687,986 		JBrowse link
G Bnip3 BCL2 interacting protein 3 IMP RGD PMID:25489073 RGD:11561978 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Hebp2 heme binding protein 2 involved_in ISO (PMID:17098234) RGD PMID:17098234 NCBI chr 1:13,194,982...13,201,777
Ensembl chr 1:13,194,982...13,201,777 		JBrowse link
G Il17a interleukin 17A IDA RGD PMID:22990529 RGD:9068935 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II IMP RGD PMID:19306371 RGD:13506652 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Mt3 metallothionein 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15129022), (PMID:16387743)		 UniProt
RGD		 PMID:15129022 PMID:16387743 GO_REF:0000024 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (PMID:20550618) RGD PMID:20550618 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO (MGI:5796070|PMID:26559832) RGD PMID:26559832 MGI:5796070 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Slc6a13 solute carrier family 6 member 13 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:24842606)		 Ensembl
RGD		 PMID:24842606 GO_REF:0000107 NCBI chr 4:154,539,246...154,577,784
Ensembl chr 4:154,540,468...154,576,152 		JBrowse link
G Slc6a6 solute carrier family 6 member 6 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:24842606)
GO_REF:0000107		 RGD
Ensembl		 PMID:24842606 GO_REF:0000107 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875 		JBrowse link
G Tspo translocator protein IMP RGD PMID:15284300 RGD:2317153 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
positive regulation of programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 involved_in ISO (MGI:6140989|PMID:27258785) RGD PMID:27258785 MGI:6140989 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3583691|PMID:16429160)		 Ensembl
RGD		 PMID:16429160 GO_REF:0000107 MGI:3583691 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Irf3 interferon regulatory factor 3 acts_upstream_of_or_within ISO MGI:3577601 (MGI:5502260|PMID:23770239) RGD PMID:23770239 MGI:5502260 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 acts_upstream_of_or_within ISO (MGI:3837511|PMID:18007661) RGD PMID:18007661 MGI:3837511 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 acts_upstream_of_or_within ISO (MGI:3837511|PMID:18007661) RGD PMID:18007661 MGI:3837511 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A acts_upstream_of_or_within ISO (MGI:3583691|PMID:16429160) RGD PMID:16429160 MGI:3583691 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (MGI:6140989|PMID:27258785) RGD PMID:27258785 MGI:6140989 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO (MGI:6140989|PMID:27258785) RGD PMID:27258785 MGI:6140989 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 acts_upstream_of_or_within ISO (MGI:3837511|PMID:18007661) RGD PMID:18007661 MGI:3837511 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh7 alkB homolog 7 involved_in ISO (PMID:23666923) RGD PMID:23666923 NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3589203 (MGI:5319417|PMID:22493254)		 Ensembl
RGD		 PMID:22493254 GO_REF:0000107 MGI:5319417 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ppif peptidylprolyl isomerase F involved_in ISS
ISO
IBA		 GO_REF:0000024
(MGI:3576003|PMID:15800626), (MGI:3603054|PMID:16103352), (MGI:5431269|PMID:22726440)
PMID:21873635
(PMID:22726440)		 UniProt
RGD		 PMID:15800626 PMID:16103352 PMID:22726440 PMID:21873635 GO_REF:0000024 MGI:3576003 MGI:3603054 MGI:5431269, RGD:13792537 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in IEA
ISO		 GO_REF:0000107
(MGI:5912943|PMID:28701375)
(PMID:27458237)		 Ensembl
RGD		 PMID:27458237 PMID:28701375 GO_REF:0000107 MGI:5912943 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Fadd Fas associated via death domain IMP RGD PMID:26038570 RGD:11341801 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Spata2 spermatogenesis associated 2 involved_in ISS
ISO
IBA		 GO_REF:0000024
(MGI:5912943|PMID:28701375)
PMID:21873635
(PMID:27307491), (PMID:27458237), (PMID:27545878)		 UniProt
RGD		 PMID:27307491 PMID:27458237 PMID:27545878 PMID:28701375 PMID:21873635 GO_REF:0000024 MGI:5912943, RGD:13792537 NCBI chr 3:156,202,962...156,213,283
Ensembl chr 3:156,202,967...156,211,705 		JBrowse link
regulation of necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm4 olfactomedin 4 NOT|involved_in ISO (PMID:23922742) RGD PMID:23922742 NCBI chr15:55,385,100...55,429,687
Ensembl chr15:55,407,148...55,429,681 		JBrowse link
G Ppif peptidylprolyl isomerase F involved_in ISO (MGI:3575990|PMID:15800627) RGD PMID:15800627 MGI:3575990 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
regulation of programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:6275115|PMID:10974027)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:10974027 GO_REF:0000024 GO_REF:0000107 MGI:6275115 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
ripoptosome assembly involved in necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (MGI:5306844|PMID:22037414) RGD PMID:22037414 MGI:5306844 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 acts_upstream_of_or_within ISO MGI:104798|MGI:1197009|MGI:1346877 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      cell death 2157
        necrotic cell death 68
          negative regulation of necrotic cell death + 26
          oncosis 1
          positive regulation of necrotic cell death + 15
          programmed necrotic cell death + 48
          regulation of necrotic cell death + 44
paths to the root