Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:necrotic cell death
go back to main search page
Accession:GO:0070265 term browser browse the term
Definition:A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
Comment:Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.
Synonyms:exact_synonym: cellular necrosis
 broad_synonym: necrosis

show annotations for term's descendants           Sort by:
 
necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsdme gasdermin E involved_in ISO (PMID:28045099)
(MGI:5901785|PMID:28045099)		 RGD PMID:28045099 MGI:5901785 NCBI chr 4:79,934,075...79,999,678
Ensembl chr 4:79,934,887...79,989,572 		JBrowse link
G Oga O-GlcNAcase IMP RGD PMID:16899550 RGD:2305957 NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276 		JBrowse link
execution phase of necroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlkl mixed lineage kinase domain like pseudokinase ISO (MGI:6434626|PMID:32296175), (MGI:6436412|PMID:32200799), (MGI:6436434|PMID:27321907) RGD PMID:27321907 PMID:32200799 PMID:32296175 MGI:6434626 MGI:6436412 MGI:6436434 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6436445|PMID:27746097), (MGI:6442612|PMID:27917412)		 UniProt
RGD		 PMID:27746097 PMID:27917412 GO_REF:0000024 MGI:6436445 MGI:6442612 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741 		JBrowse link
necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in ISO
IBA		 MGI:104798|MGI:108212|MGI:1261423|MGI:2154952 (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5824599|PMID:27545878)
PMID:21873635		 RGD PMID:21052097 PMID:22037414 PMID:27545878, PMID:21873635, PMID:21873635 MGI:5306844 MGI:5315337 MGI:5824599, RGD:13792537, RGD:13792537 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357 		JBrowse link
G Dnm1l dynamin 1-like involved_in ISO
ISS		 (PMID:22265414)
GO_REF:0000024
(MGI:5516181|PMID:22265414)		 RGD
UniProt		 PMID:22265414 GO_REF:0000024 MGI:5516181 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198 		JBrowse link
G Faslg Fas ligand involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Ipmk inositol polyphosphate multikinase involved_in ISS
ISO		 GO_REF:0000024
(PMID:29883610)		 UniProt
RGD		 PMID:29883610 GO_REF:0000024 NCBI chr20:18,457,309...18,489,884
Ensembl chr20:18,457,310...18,489,833 		JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase involved_in ISO (PMID:29883610) RGD PMID:29883610 NCBI chr 6:126,448,920...126,582,188
Ensembl chr 6:126,450,139...126,582,134 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISS
ISO		 GO_REF:0000024
(PMID:22265414), (PMID:24316671), (PMID:29883610)
(MGI:5532892|PMID:24012422), (MGI:5532894|PMID:23835476)		 UniProt
RGD		 PMID:22265414 PMID:23835476 PMID:24012422 PMID:24316671 PMID:29883610 GO_REF:0000024 MGI:5532892 MGI:5532894 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851 		JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:22265414)
(MGI:5516181|PMID:22265414)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:22265414 GO_REF:0000024 GO_REF:0000107 MGI:5516181 NCBI chr12:52,467,417...52,474,533
Ensembl chr12:52,467,450...52,474,511 		JBrowse link
G Ppif peptidylprolyl isomerase F ISO MGI:98834 (MGI:5431269|PMID:22726440) RGD PMID:22726440 MGI:5431269 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908 		JBrowse link
G Pygl glycogen phosphorylase L ISO MGI:2154952 (MGI:5510543|PMID:19498109) RGD PMID:19498109 MGI:5510543 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:21737330), (PMID:22265414), (PMID:29440439)
MGI:104798|MGI:1921506|MGI:2154952|MGI:95484 (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5510543|PMID:19498109), (MGI:5912943|PMID:28701375), (MGI:5926457|PMID:28842570), (MGI:6120592|PMID:29440439), (MGI:6362112|PMID:31519886), (MGI:6362574|PMID:31519887), (MGI:6369186|PMID:30867408)		 UniProt
RGD		 PMID:19498109 PMID:21052097 PMID:21737330 PMID:22037414 PMID:22265414 PMID:28701375 PMID:28842570 PMID:29440439 PMID:30867408 PMID:31519886 PMID:31519887 GO_REF:0000024 MGI:5306844 MGI:5315337 MGI:5510543 MGI:5912943 MGI:5926457 MGI:6120592 MGI:6362112 MGI:6362574 MGI:6369186 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:21737330), (PMID:29883609)
MGI:104798|MGI:108212|MGI:109324|MGI:1261423|MGI:1336166|MGI:1921506 (MGI:4947443|PMID:21368763), (MGI:5294742|PMID:21402742), (MGI:5306844|PMID:22037414), (MGI:5486419|PMID:22675671), (MGI:5510543|PMID:19498109), (MGI:5532892|PMID:24012422)		 UniProt
RGD		 PMID:19498109 PMID:21368763 PMID:21402742 PMID:21737330 PMID:22037414 PMID:22675671 PMID:24012422 PMID:29883609 GO_REF:0000024 MGI:4947443 MGI:5294742 MGI:5306844 MGI:5486419 MGI:5510543 MGI:5532892 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741 		JBrowse link
G Spata2 spermatogenesis associated 2 ISO
IEA		 (MGI:5824599|PMID:27545878)
GO_REF:0000107		 RGD
Ensembl		 PMID:27545878 GO_REF:0000107 MGI:5824599 NCBI chr 3:164,229,211...164,239,483
Ensembl chr 3:164,230,852...164,239,250 		JBrowse link
G Tp53 tumor protein p53 ISO MGI:2145814 (MGI:5431269|PMID:22726440) RGD PMID:22726440 MGI:5431269 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 involved_in ISO
IEA
ISS		 (PMID:24316671)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:24316671 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:119,258,189...119,347,084
Ensembl chr 3:119,259,467...119,330,345 		JBrowse link
necroptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628 		JBrowse link
G Fas Fas cell surface death receptor involved_in ISO
IBA		 (PMID:16507998)
PMID:21873635
MGI:108212 (MGI:5315337|PMID:21052097)		 RGD PMID:16507998 PMID:21052097, PMID:21873635, PMID:21873635 MGI:5315337, RGD:13792537, RGD:13792537 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand involved_in ISO (PMID:11101870) RGD PMID:11101870 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G LOC103694380 tumor necrosis factor-like involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr20:4,855,792...4,858,447
Ensembl chr20:4,855,829...4,858,447 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO (PMID:22265413)
(MGI:5516182|PMID:22265413)		 RGD PMID:22265413 MGI:5516182 NCBI chr19:43,508,416...43,535,050
Ensembl chr19:43,506,976...43,528,851 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:11101870), (PMID:16507998), (PMID:22265413), (PMID:22817896), (PMID:31827280)
(MGI:5291865|PMID:21876153), (MGI:6401044|PMID:31827281)		 UniProt
RGD		 PMID:11101870 PMID:16507998 PMID:21876153 PMID:22265413 PMID:22817896 PMID:31827280 PMID:31827281 GO_REF:0000024 MGI:5291865 MGI:6401044 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO (PMID:22265413), (PMID:22817896) RGD PMID:22265413 PMID:22817896 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741 		JBrowse link
G Tlr3 toll-like receptor 3 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214 		JBrowse link
G Tnf tumor necrosis factor involved_in ISS
ISO		 GO_REF:0000024
(PMID:11101870), (PMID:22265413), (PMID:22265414), (PMID:22817896)
MGI:108212|MGI:1197009|MGI:1261423|MGI:1336166|MGI:1346877|MGI:1921506|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5306844|PMID:22037414), (MGI:5315337|PMID:21052097), (MGI:5510543|PMID:19498109)		 UniProt
RGD		 PMID:11101870 PMID:19498109 PMID:21052097 PMID:21368763 PMID:22037414 PMID:22265413 PMID:22265414 PMID:22817896 GO_REF:0000024 MGI:4947443 MGI:5306844 MGI:5315337 MGI:5510543 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
negative regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:22711822) RGD PMID:22711822 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 involved_in ISO
IBA		 MGI:104798 (MGI:5315337|PMID:21052097)
PMID:21873635		 RGD PMID:21052097, PMID:21873635, PMID:21873635 MGI:5315337, RGD:13792537, RGD:13792537 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in ISO
IBA		 (MGI:5315337|PMID:21052097)
PMID:21873635		 RGD PMID:21052097, PMID:21873635, PMID:21873635 MGI:5315337, RGD:13792537, RGD:13792537 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK ISO (MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:5796062 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504 		JBrowse link
G Casp8 caspase 8 involved_in ISS
ISO		 GO_REF:0000024
(PMID:31827280)
MGI:104798|MGI:1336166|MGI:1921506|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5294742|PMID:21402742), (MGI:5306844|PMID:22037414), (MGI:5521568|PMID:22089168), (MGI:6378798|PMID:31511692), (MGI:6401035|PMID:31748744), (MGI:6401044|PMID:31827281)		 UniProt
RGD		 PMID:21368763 PMID:21402742 PMID:22037414 PMID:22089168 PMID:31511692 PMID:31748744 PMID:31827280 PMID:31827281 GO_REF:0000024 MGI:4947443 MGI:5294742 MGI:5306844 MGI:5521568 MGI:6378798 MGI:6401035 MGI:6401044 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cav1 caveolin 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5464050|PMID:23049990)		 Ensembl
RGD		 PMID:23049990 GO_REF:0000107 MGI:5464050 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator ISO MGI:104798|MGI:1261423|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168) RGD PMID:21368763 PMID:22089168 PMID:22675671 MGI:4947443 MGI:5486419 MGI:5521568 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Fadd Fas associated via death domain ISO MGI:104798|MGI:2154952 (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168) RGD PMID:22089168 PMID:22675671 MGI:5486419 MGI:5521568 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416 		JBrowse link
G Mutyh mutY DNA glycosylase involved_in IEA
ISO		 GO_REF:0000107
(MGI:6378777|PMID:28059467)		 Ensembl
RGD		 PMID:28059467 GO_REF:0000107 MGI:6378777 NCBI chr 5:135,663,328...135,675,348
Ensembl chr 5:135,663,371...135,675,344 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 involved_in ISO (PMID:29883609)
(MGI:6163945|PMID:29883609)		 RGD PMID:29883609 MGI:6163945 NCBI chr14:106,008,086...106,062,566
Ensembl chr14:106,008,086...106,061,641 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in IEA
ISO		 GO_REF:0000107
MGI:104798 (MGI:5521568|PMID:22089168)		 Ensembl
RGD		 PMID:22089168 GO_REF:0000107 MGI:5521568 NCBI chr 3:147,793,014...147,809,941
Ensembl chr 3:147,793,017...147,809,919 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (MGI:5602910|PMID:24813850), (MGI:5602911|PMID:24813849), (MGI:5907398|PMID:27819682), (MGI:5907399|PMID:27819681) RGD PMID:24813849 PMID:24813850 PMID:27819681 PMID:27819682 MGI:5602910 MGI:5602911 MGI:5907398 MGI:5907399 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904 		JBrowse link
G Rnf31 ring finger protein 31 ISO MGI:104798 (MGI:5521568|PMID:22089168) RGD PMID:22089168 MGI:5521568 NCBI chr15:34,270,037...34,282,385
Ensembl chr15:34,270,648...34,282,495 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 involved_in ISO
IEA		 (PMID:16507998)
GO_REF:0000107		 RGD
Ensembl		 PMID:16507998 GO_REF:0000107 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698 		JBrowse link
G Ybx3 Y box binding protein 3 involved_in ISO
IEA		 (PMID:22711822)
GO_REF:0000107		 RGD
Ensembl		 PMID:22711822 GO_REF:0000107 NCBI chr 4:165,606,819...165,630,041
Ensembl chr 4:165,606,819...165,630,118 		JBrowse link
negative regulation of necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor ISO (MGI:3794480|PMID:16443691) RGD PMID:16443691 MGI:3794480 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Fth1 ferritin heavy chain 1 IMP RGD PMID:18992754 RGD:2315110 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228 		JBrowse link
G Mt3 metallothionein 3 involved_in ISO
ISS		 (PMID:18554677)
GO_REF:0000024
(MGI:5315682|PMID:20371971)		 RGD
UniProt		 PMID:18554677 PMID:20371971 GO_REF:0000024 MGI:5315682 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139 		JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 IMP RGD PMID:26888427 RGD:11040458 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5617337|PMID:24440909)		 Ensembl
RGD		 PMID:24440909 GO_REF:0000107 MGI:5617337 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649 		JBrowse link
G Ucn urocortin IDA RGD PMID:20933497 RGD:5508190 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974 		JBrowse link
negative regulation of programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISS
ISO		 GO_REF:0000024
(PMID:30451898)		 UniProt
RGD		 PMID:30451898 GO_REF:0000024 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
negative regulation of ripoptosome assembly involved in necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 ISO MGI:104798|MGI:108212 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO MGI:104798|MGI:108212 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416 		JBrowse link
oncosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tmem123 transmembrane protein 123 involved_in ISO (PMID:11481458), (PMID:9600958) RGD PMID:9600958 PMID:11481458 NCBI chr 8:5,967,373...5,997,387
Ensembl chr 8:5,967,463...5,997,383 		JBrowse link
positive regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gzmb granzyme B IMP RGD PMID:19895873 RGD:2325193 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in IMP
ISO		 (PMID:22028622), (PMID:22274400), (PMID:22817896) RGD PMID:22028622 PMID:22274400 PMID:22817896, PMID:22372834 RGD:7777172 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISO
ISS		 (PMID:22265414), (PMID:22817896)
GO_REF:0000024
(MGI:5315337|PMID:21052097), (MGI:5516181|PMID:22265414), (MGI:5602910|PMID:24813850), (MGI:5602911|PMID:24813849), (MGI:6434626|PMID:32296175), (MGI:6436371|PMID:22423968), (MGI:6436412|PMID:32200799), (MGI:6436434|PMID:27321907)		 RGD
UniProt		 PMID:21052097 PMID:22265414 PMID:22423968 PMID:22817896 PMID:24813849 PMID:24813850 PMID:27321907 PMID:32200799 PMID:32296175 GO_REF:0000024 MGI:5315337 MGI:5516181 MGI:5602910 MGI:5602911 MGI:6434626 MGI:6436371 MGI:6436412 MGI:6436434 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741 		JBrowse link
G Zbp1 Z-DNA binding protein 1 involved_in ISO
ISS		 (PMID:32200799)
GO_REF:0000024
(MGI:5907398|PMID:27819682), (MGI:5907399|PMID:27819681), (MGI:6095612|PMID:29073079), (MGI:6434626|PMID:32296175), (MGI:6436371|PMID:22423968), (MGI:6436393|PMID:30050136), (MGI:6436412|PMID:32200799), (MGI:6436445|PMID:27746097), (MGI:6442612|PMID:27917412)		 RGD
UniProt		 PMID:22423968 PMID:27746097 PMID:27819681 PMID:27819682 PMID:27917412 PMID:29073079 PMID:30050136 PMID:32200799 PMID:32296175 GO_REF:0000024 MGI:5907398 MGI:5907399 MGI:6095612 MGI:6434626 MGI:6436371 MGI:6436393 MGI:6436412 MGI:6436445 MGI:6442612 NCBI chr 3:171,276,062...171,292,062
Ensembl chr 3:171,276,062...171,286,537 		JBrowse link
positive regulation of necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bnip3 BCL2 interacting protein 3 IMP RGD PMID:25489073 RGD:11561978 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Hebp2 heme binding protein 2 involved_in ISO (PMID:17098234) RGD PMID:17098234 NCBI chr 1:13,713,152...13,719,970
Ensembl chr 1:13,714,440...13,719,829 		JBrowse link
G Il17a interleukin 17A IDA RGD PMID:22990529 RGD:9068935 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II IMP RGD PMID:19306371 RGD:13506652 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Mt3 metallothionein 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15129022), (PMID:16387743)		 UniProt
RGD		 PMID:15129022 PMID:16387743 GO_REF:0000024 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (PMID:20550618) RGD PMID:20550618 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 ISO (MGI:5796070|PMID:26559832) RGD PMID:26559832 MGI:5796070 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741 		JBrowse link
G Slc6a13 solute carrier family 6 member 13 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:24842606)
GO_REF:0000107		 RGD
Ensembl		 PMID:24842606 GO_REF:0000107 NCBI chr 4:153,874,942...153,912,185
Ensembl chr 4:153,874,852...153,912,155 		JBrowse link
G Slc6a6 solute carrier family 6 member 6 acts_upstream_of ISO (PMID:24842606) RGD PMID:24842606 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464 		JBrowse link
G Tspo translocator protein IMP RGD PMID:15284300 RGD:2317153 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609 		JBrowse link
positive regulation of programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 ISO (MGI:6140989|PMID:27258785) RGD PMID:27258785 MGI:6140989 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3583691|PMID:16429160)		 Ensembl
RGD		 PMID:16429160 GO_REF:0000107 MGI:3583691 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Irf3 interferon regulatory factor 3 ISO MGI:3577601 (MGI:5502260|PMID:23770239) RGD PMID:23770239 MGI:5502260 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO (MGI:3837511|PMID:18007661) RGD PMID:18007661 MGI:3837511 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO (MGI:3837511|PMID:18007661) RGD PMID:18007661 MGI:3837511 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A ISO (MGI:3583691|PMID:16429160) RGD PMID:16429160 MGI:3583691 NCBI chr10:57,692,474...57,747,608
Ensembl chr10:57,692,474...57,822,498 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (MGI:6140989|PMID:27258785) RGD PMID:27258785 MGI:6140989 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 ISO (MGI:6140989|PMID:27258785) RGD PMID:27258785 MGI:6140989 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO (MGI:3837511|PMID:18007661) RGD PMID:18007661 MGI:3837511 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620 		JBrowse link
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh7 alkB homolog 7 involved_in ISO (PMID:23666923) RGD PMID:23666923 NCBI chr 9:10,045,375...10,047,507
Ensembl chr 9:10,045,375...10,047,507 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in IEA
ISO		 GO_REF:0000107
MGI:3589203 (MGI:5319417|PMID:22493254)		 Ensembl
RGD		 PMID:22493254 GO_REF:0000107 MGI:5319417 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Ppif peptidylprolyl isomerase F involved_in ISO
ISS
IBA		 (PMID:22726440)
GO_REF:0000024
PMID:21873635
(MGI:3576003|PMID:15800626), (MGI:3603054|PMID:16103352), (MGI:5431269|PMID:22726440)		 RGD
UniProt		 PMID:15800626 PMID:16103352 PMID:22726440, PMID:21873635, PMID:21873635 GO_REF:0000024 MGI:3576003 MGI:3603054 MGI:5431269, RGD:13792537, RGD:13792537 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908 		JBrowse link
regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator involved_in ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in IEA
ISO		 GO_REF:0000107
(PMID:27458237)
(MGI:5912943|PMID:28701375)		 Ensembl
RGD		 PMID:27458237 PMID:28701375 GO_REF:0000107 MGI:5912943 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357 		JBrowse link
G Fadd Fas associated via death domain IMP RGD PMID:26038570 RGD:11341801 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628 		JBrowse link
G Spata2 spermatogenesis associated 2 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:27307491), (PMID:27458237), (PMID:27545878)
PMID:21873635
(MGI:5912943|PMID:28701375)		 UniProt
RGD		 PMID:27307491 PMID:27458237 PMID:27545878 PMID:28701375, PMID:21873635 GO_REF:0000024 MGI:5912943, RGD:13792537 NCBI chr 3:164,229,211...164,239,483
Ensembl chr 3:164,230,852...164,239,250 		JBrowse link
regulation of necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm4 olfactomedin 4 NOT
NOT|involved_in		 ISO (PMID:23922742) RGD PMID:23922742 NCBI chr15:62,384,263...62,429,450
Ensembl chr15:62,406,873...62,429,449 		JBrowse link
G Ppif peptidylprolyl isomerase F ISO (MGI:3575990|PMID:15800627) RGD PMID:15800627 MGI:3575990 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908 		JBrowse link
regulation of programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:6275115|PMID:10974027)		 UniProt
Ensembl
RGD		 PMID:10974027 GO_REF:0000024 GO_REF:0000107 MGI:6275115 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836 		JBrowse link
ripoptosome assembly involved in necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase ISO (MGI:5306844|PMID:22037414) RGD PMID:22037414 MGI:5306844 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO MGI:104798|MGI:1197009|MGI:1346877 (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    cellular process 18896
      cell death 2141
        necrotic cell death 62
          negative regulation of necrotic cell death + 23
          oncosis 1
          positive regulation of necrotic cell death + 13
          programmed necrotic cell death + 45
          regulation of necrotic cell death + 39
paths to the root