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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of biomineral tissue development
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Accession:GO:0070168 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.



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negative regulation of biomineral tissue development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gas6 growth arrest specific 6 involved_in ISO
ISS
(PMID:20048160)
GO_REF:0000024
RGD
UniProt
PMID:20048160 GO_REF:0000024 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 involved_in ISO (MGI:6158746|PMID:22110751) RGD PMID:22110751 MGI:6158746 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 involved_in ISO (MGI:6158746|PMID:22110751) RGD PMID:22110751 MGI:6158746 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Nos3 nitric oxide synthase 3 involved_in IEA
ISO
GO_REF:0000107
(MGI:6158885|PMID:23583836)
Ensembl
RGD
PMID:23583836 GO_REF:0000107 MGI:6158885 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:6158728|PMID:26491108), (MGI:6158885|PMID:23583836) RGD PMID:23583836 PMID:26491108 MGI:6158728 MGI:6158885 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO UniProtKB:M3TYT0 (PMID:26634652) RGD PMID:26634652 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO UniProtKB:I3LFH3 (PMID:26634652) RGD PMID:26634652 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in ISS
ISO
GO_REF:0000024
(MGI:4947506|PMID:20056916)
(PMID:22110751)
UniProt
RGD
PMID:20056916 PMID:22110751 GO_REF:0000024 MGI:4947506 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO (PMID:26634652)
(MGI:5921830|PMID:26634652)
RGD PMID:26634652 MGI:5921830 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
negative regulation of bone mineralization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein involved_in IMP
ISO
ISS
(MGI:3687916|PMID:12556469)
GO_REF:0000024
RGD
UniProt
PMID:12556469 PMID:8702833 GO_REF:0000024 MGI:3687916, RGD:1626074 NCBI chr11:78,117,903...78,145,956 JBrowse link
G Bcor BCL6 co-repressor involved_in ISO (PMID:19578371) RGD PMID:19578371 NCBI chr  X:10,609,756...10,729,613
Ensembl chr  X:10,687,732...10,729,613
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 involved_in ISO (PMID:21403648) RGD PMID:21403648 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 involved_in ISO (PMID:21403648) RGD PMID:21403648 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr1l1 chemokine (C-C motif) receptor 1-like 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:123,589,997...123,613,767
Ensembl chr 8:123,589,621...123,612,687
JBrowse link
G Ecm1 extracellular matrix protein 1 involved_in ISO
ISS
(PMID:11165938)
GO_REF:0000024
RGD
UniProt
PMID:11165938 GO_REF:0000024 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5607146|PMID:25479107), (MGI:6220772|PMID:30111653), (MGI:6294341|PMID:22510396)
UniProt
RGD
PMID:22510396 PMID:25479107 PMID:30111653 GO_REF:0000024 MGI:5607146 MGI:6220772 MGI:6294341 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Fgf23 fibroblast growth factor 23 involved_in ISO (PMID:18282132) RGD PMID:18282132 NCBI chr 4:159,914,393...159,922,073
Ensembl chr 4:159,914,272...159,923,821
JBrowse link
G Gata1 GATA binding protein 1 acts_upstream_of_or_within ISO MGI:2177586 (MGI:3653541|PMID:15005853) RGD PMID:15005853 MGI:3653541 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:15539560) RGD PMID:15539560 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857719 (MGI:3777866|PMID:17181398)
Ensembl
RGD
PMID:17181398 GO_REF:0000107 MGI:3777866 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (MGI:2178869|PMID:11790802) RGD PMID:11790802 MGI:2178869 NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975
JBrowse link
G Mepe matrix extracellular phosphoglycoprotein acts_upstream_of_or_within ISO MGI:2448895 (MGI:2448336|PMID:12421822), (MGI:3851320|PMID:15843468), (MGI:5431257|PMID:22766095) RGD PMID:12421822 PMID:15843468 PMID:22766095 MGI:2448336 MGI:3851320 MGI:5431257 NCBI chr14:5,420,634...5,432,186
Ensembl chr14:5,420,635...5,432,183
JBrowse link
G Nfe2 nuclear factor, erythroid 2 acts_upstream_of_or_within ISO MGI:1857224 (MGI:3653541|PMID:15005853) RGD PMID:15005853 MGI:3653541 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO
GO_REF:0000024
(MGI:3713957|PMID:17537919)
UniProt
RGD
PMID:17537919 GO_REF:0000024 MGI:3713957 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO MGI:2158693 (MGI:2135696|PMID:11371614) RGD PMID:11371614 MGI:2135696 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Srgn serglycin involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:16870619)
UniProt
RGD
PMID:16870619 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:23081848 RGD:10003033 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
negative regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:15539560) RGD PMID:15539560 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
JBrowse link
G Pth parathyroid hormone involved_in IMP PMID:11604398 CAFA PMID:11604398 RGD:12793028 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Rflna refilin A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1923816 (MGI:5570967|PMID:24436304)
RGD PMID:24436304 PMID:21873635 MGI:5570967, RGD:13792537 NCBI chr12:31,633,361...31,642,317
Ensembl chr12:31,633,361...31,642,317
JBrowse link
G Rflnb refilin B involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1920371 (MGI:5570967|PMID:24436304)
RGD PMID:24436304 PMID:21873635 MGI:5570967, RGD:13792537 NCBI chr10:60,893,693...60,899,970
Ensembl chr10:60,893,713...60,899,976
JBrowse link
negative regulation of tooth mineralization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aspn asporin involved_in ISO (MGI:3722035|PMID:17522060) RGD PMID:17522060 MGI:3722035 NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041
JBrowse link
G Bcor BCL6 co-repressor involved_in ISO (PMID:19578371) RGD PMID:19578371 NCBI chr  X:10,609,756...10,729,613
Ensembl chr  X:10,687,732...10,729,613
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    negative regulation of biological process 5677
      negative regulation of biomineralization 31
        negative regulation of biomineral tissue development 30
          negative regulation of bone mineralization + 21
          negative regulation of shell calcification 0
          negative regulation of tooth mineralization + 2
Path 2
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure development 6306
        multicellular organism development 5727
          system development 5373
            animal organ development 4130
              biomineral tissue development 178
                regulation of biomineral tissue development 104
                  negative regulation of biomineral tissue development 30
                    negative regulation of bone mineralization + 21
                    negative regulation of shell calcification 0
                    negative regulation of tooth mineralization + 2
paths to the root