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ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
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Accession:GO:0070059 term browser browse the term
Definition:The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Synonyms:exact_synonym: ER stress-induced apoptosis;   apoptosis in response to ER stress;   apoptosis triggered by ER stress;   endoplasmic reticulum stress-induced apoptosis;   intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress
 broad_synonym: apoptosis in response to endoplasmic reticulum stress


show annotations for term's descendants           Sort by:
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07005775.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Aifm1 apoptosis inducing factor, mitochondria associated 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:18056262) 		UniProt
RGD		 PMID:18056262 GO_REF:0000024 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 involved_in ISO
IEA 		(PMID:16407291)
GO_REF:0000107 		RGD
Ensembl		 PMID:16407291 GO_REF:0000107 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atf4 activating transcription factor 4 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:21159964), (PMID:23624402) 		UniProt
Ensembl
RGD		 PMID:21159964 PMID:23624402 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 involved_in ISO
IEA 		(PMID:19061639)
GO_REF:0000107 		RGD
Ensembl		 PMID:19061639 GO_REF:0000107 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 involved_in ISO (PMID:16725111) RGD PMID:16725111 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:18056262)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:18056262 GO_REF:0000024 GO_REF:0000107 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 acts_upstream_of_or_within ISO
IEA 		MGI:99702|UniProtKB:P10415 (PMID:12847083), (PMID:15776018)
GO_REF:0000107 		RGD
Ensembl		 PMID:12847083 PMID:15776018 GO_REF:0000107 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO
IEA 		MGI:1097161|UniProtKB:P10415 (PMID:12847083), (PMID:15776018)
GO_REF:0000107 		RGD
Ensembl		 PMID:12847083 PMID:15776018 GO_REF:0000107 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in ISS
IBA
ISO 		GO_REF:0000024
GO_REF:0000033
(PMID:16407291), (PMID:21159964), (PMID:22761832) 		UniProt
GO_Central
RGD		 PMID:16407291 PMID:21159964 PMID:22761832 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO (PMID:15776018) RGD PMID:15776018 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Brsk2 BR serine/threonine kinase 2 involved_in ISO
IEA 		(PMID:22713462)
GO_REF:0000107 		RGD
Ensembl		 PMID:22713462 GO_REF:0000107 NCBI chr 1:197,035,505...197,088,624
Ensembl chr 1:197,035,633...197,088,092 		JBrowse link
G Casp12 caspase 12 involved_in
acts_upstream_of_or_within 		NAS
ISO
IEA 		PMID:10638761
(PMID:10638761), (PMID:12097332)
MGI:1097161|MGI:99702 (PMID:12847083)
GO_REF:0000107 		RGD
Ensembl		 PMID:10638761 PMID:12097332 PMID:12847083 PMID:10638761 GO_REF:0000107, RGD:10047306 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp4 caspase 4 involved_in ISO (PMID:15123740) RGD PMID:15123740 NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta involved_in IEA
ISO 		GO_REF:0000107
(PMID:9531536) 		Ensembl
RGD		 PMID:9531536 GO_REF:0000107 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 involved_in ISO
IEA 		(PMID:19109178)
GO_REF:0000107 		RGD
Ensembl		 PMID:19109178 GO_REF:0000107 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO
IEA 		(PMID:18281285)
GO_REF:0000107 		RGD
Ensembl		 PMID:18281285 GO_REF:0000107 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in
acts_upstream_of_or_within 		ISS
IEA
ISO
IBA 		GO_REF:0000024
GO_REF:0000107
(PMID:21159964), (PMID:23624402), (PMID:9531536)
MGI:2179046 (PMID:11854325)
GO_REF:0000033
(PMID:15322075), (PMID:18940792), (PMID:20829347) 		UniProt
Ensembl
RGD
GO_Central		 PMID:9531536 PMID:11854325 PMID:15322075 PMID:18940792 PMID:20829347 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 involved_in ISO (PMID:19122239) RGD PMID:19122239 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO MGI:2177666 (PMID:11430819) RGD PMID:11430819 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:11146108), (PMID:19328063) 		GO_Central
Ensembl
RGD		 PMID:11146108 PMID:19328063 GO_REF:0000033 GO_REF:0000107 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:9755171) 		GO_Central
Ensembl
RGD		 PMID:9755171 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:19752026) 		UniProt
Ensembl
RGD		 PMID:19752026 GO_REF:0000024 GO_REF:0000107 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO (PMID:23028846) RGD PMID:23028846 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ins2 insulin 2 acts_upstream_of_or_within ISO
IEA 		MGI:1857572 (PMID:11854325)
GO_REF:0000107 		RGD
Ensembl		 PMID:11854325 GO_REF:0000107 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:19752026)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:19752026 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 involved_in ISO
IEA
IBA 		(PMID:12050113)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:12050113 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 acts_upstream_of ISO
IEA 		MGI:2181360 (PMID:20811152)
GO_REF:0000107 		RGD
Ensembl		 PMID:20811152 GO_REF:0000107 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:16407291) RGD PMID:16407291 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold acts_upstream_of_or_within ISO
IEA 		(PMID:21030605)
GO_REF:0000107 		RGD
Ensembl		 PMID:21030605 GO_REF:0000107 NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO
IEA 		(PMID:33384352)
GO_REF:0000107 		RGD
Ensembl		 PMID:33384352 GO_REF:0000107 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Rnf186 ring finger protein 186 involved_in ISO
IEA
IBA 		(PMID:23896122)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:23896122 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:156,493,750...156,494,974
Ensembl chr 5:151,210,492...151,211,716 		JBrowse link
G Selenok selenoprotein K involved_in ISO
IEA 		(PMID:20692228)
GO_REF:0000107 		RGD
Ensembl		 PMID:20692228 GO_REF:0000107 NCBI chr16:5,152,066...5,160,648
Ensembl chr16:5,152,066...5,159,188 		JBrowse link
G Spop speckle type BTB/POZ protein acts_upstream_of ISO
IEA 		MGI:102851 (PMID:20811152)
GO_REF:0000107 		RGD
Ensembl		 PMID:20811152 GO_REF:0000107 NCBI chr10:80,358,121...80,438,983
Ensembl chr10:80,358,124...80,483,955 		JBrowse link
G Syvn1 synoviolin 1 acts_upstream_of ISO MGI:2679656 (PMID:15611074) RGD PMID:15611074 NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 acts_upstream_of_or_within ISO MGI:3052422 (PMID:15304216) RGD PMID:15304216 NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
G Tmem117 transmembrane protein 117 involved_in ISO
IEA
IBA 		(PMID:28285135)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:28285135 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:125,757,591...126,219,692
Ensembl chr 7:125,757,591...126,219,690 		JBrowse link
G Tmem238l transmembrane protein 238 like involved_in ISO (PMID:33112233) RGD PMID:33112233 NCBI chr10:51,647,871...51,662,206 JBrowse link
G Tp53 tumor protein p53 involved_in IEA
ISO 		GO_REF:0000107
(PMID:16407291) 		Ensembl
RGD		 PMID:16407291 GO_REF:0000107 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trib3 tribbles pseudokinase 3 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:15775988) 		UniProt
Ensembl
RGD		 PMID:15775988 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K acts_upstream_of_or_within IMP PMID:18710920 MGI PMID:18710920 RGD:8554156 NCBI chr14:43,011,681...43,077,825
Ensembl chr14:42,658,016...42,718,630 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
IEA 		(PMID:19328063)
GO_REF:0000107 		RGD
Ensembl		 PMID:19328063 GO_REF:0000107 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 involved_in ISO
ISS 		(PMID:29507230)
GO_REF:0000024 		RGD
UniProt		 PMID:29507230 GO_REF:0000024 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Creb3 cAMP responsive element binding protein 3 involved_in ISO
IEA 		(PMID:16940180)
GO_REF:0000107 		RGD
Ensembl		 PMID:16940180 GO_REF:0000107 NCBI chr 5:57,817,865...57,823,233
Ensembl chr 5:57,817,832...57,824,390 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 involved_in IMP
ISO 		PMID:15665855
(PMID:15665855) 		RGD PMID:15665855 PMID:15665855 RGD:1558627 NCBI chr 3:98,408,240...98,449,104
Ensembl chr 3:77,952,540...77,993,456 		JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 acts_upstream_of_or_within ISO
IEA 		MGI:1341830|MGI:99682 (PMID:22240901)
GO_REF:0000107 		RGD
Ensembl		 PMID:22240901 GO_REF:0000107 NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO
IEA
IBA 		(PMID:15102845)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:15102845 GO_REF:0000033 GO_REF:0000107 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:12150907), (PMID:20625543) RGD PMID:12150907 PMID:20625543 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:12150907), (PMID:20625543) RGD PMID:12150907 PMID:20625543 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in ISO (PMID:23453807) RGD PMID:23453807 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO
IEA 		(PMID:21857923)
GO_REF:0000107 		RGD
Ensembl		 PMID:21857923 GO_REF:0000107 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Ngf nerve growth factor involved_in NAS PMID:21266243 ParkinsonsUK-UCL PMID:21266243 RGD:10047230 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:23453807)
UniProtKB:P58281 (PMID:23453807) 		ParkinsonsUK-UCL
Ensembl
RGD		 PMID:23453807 GO_REF:0000024 GO_REF:0000107 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO UniProtKB:Q99LX0 (PMID:14652021) RGD PMID:14652021 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 acts_upstream_of_or_within ISO
IEA 		MGI:2181360 (PMID:20811152)
GO_REF:0000107 		RGD
Ensembl		 PMID:20811152 GO_REF:0000107 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:21113145)
(PMID:10973942), (PMID:11439185), (PMID:12150907), (PMID:21113145), (PMID:23453807) 		ParkinsonsUK-UCL
Ensembl
RGD		 PMID:10973942 PMID:11439185 PMID:12150907 PMID:21113145 PMID:23453807 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IEA 		(PMID:21216966)
GO_REF:0000107 		RGD
Ensembl		 PMID:21216966 GO_REF:0000107 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA 		(PMID:17210132)
GO_REF:0000107 		RGD
Ensembl		 PMID:17210132 GO_REF:0000107 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Syvn1 synoviolin 1 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:12459480), (PMID:17059562)
GO_REF:0000107
MGI:2679656 (PMID:15611074) 		RGD
Ensembl		 PMID:12459480 PMID:15611074 PMID:17059562 GO_REF:0000107 NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in
acts_upstream_of_or_within 		ISO (PMID:21075086)
MGI:1913418 (PMID:22240901) 		RGD PMID:21075086 PMID:22240901 NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
G Txndc12 thioredoxin domain containing 12 acts_upstream_of_or_within ISO
IEA 		(PMID:18628206)
GO_REF:0000107 		RGD
Ensembl		 PMID:18628206 GO_REF:0000107 NCBI chr 5:123,587,854...123,612,886
Ensembl chr 5:123,586,781...123,612,870 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO
IEA 		(PMID:16571599)
GO_REF:0000107 		RGD
Ensembl		 PMID:16571599 GO_REF:0000107 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
IEA
IMP 		(PMID:19135031)
GO_REF:0000107
PMID:20625543 		RGD
Ensembl		 PMID:19135031 PMID:20625543 GO_REF:0000107, RGD:10047191 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyou1 hypoxia up-regulated 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:17116640) 		Ensembl
RGD		 PMID:17116640 GO_REF:0000107 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:O15354 (PMID:17116640), (PMID:23453807) 		Ensembl
RGD		 PMID:17116640 PMID:23453807 GO_REF:0000107 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tmbim6 transmembrane BAX inhibitor motif containing 6 acts_upstream_of_or_within ISO MGI:3052422 (PMID:15304216) RGD PMID:15304216 NCBI chr 7:130,527,313...130,542,567
Ensembl chr 7:130,527,316...130,543,633 		JBrowse link
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:26015568), (PMID:26949185) 		UniProt
Ensembl
RGD		 PMID:26015568 PMID:26949185 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in ISO
IEA 		(PMID:22761832)
GO_REF:0000107 		RGD
Ensembl		 PMID:22761832 GO_REF:0000107 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO MGI:1913418 (PMID:22240901) RGD PMID:22240901 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IEA
IBA 		(PMID:14676213)
GO_REF:0000107
GO_REF:0000033
UniProtKB:O55033 (PMID:16835242) 		RGD
Ensembl
GO_Central		 PMID:14676213 PMID:16835242 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IEA
IBA 		UniProtKB:Q99M51 (PMID:16835242)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:16835242 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:21216966) 		Ensembl
RGD		 PMID:21216966 GO_REF:0000107 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Rnf183 ring finger protein 183 involved_in ISO
IEA
IBA 		(PMID:29507230)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:29507230 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:80,892,683...80,914,037
Ensembl chr 5:75,876,003...75,886,191 		JBrowse link
G Serinc3 serine incorporator 3 acts_upstream_of_or_within ISO
IEA 		(PMID:12486168)
GO_REF:0000107 		RGD
Ensembl		 PMID:12486168 GO_REF:0000107 NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808 		JBrowse link
G Sirt1 sirtuin 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:20955178) 		Ensembl
RGD		 PMID:20955178 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Spop speckle type BTB/POZ protein acts_upstream_of_or_within ISO
IEA 		MGI:102851 (PMID:20811152)
GO_REF:0000107 		RGD
Ensembl		 PMID:20811152 GO_REF:0000107 NCBI chr10:80,358,121...80,438,983
Ensembl chr10:80,358,124...80,483,955 		JBrowse link
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO
IEA 		(PMID:23000344)
GO_REF:0000107 		RGD
Ensembl		 PMID:23000344 GO_REF:0000107 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 involved_in ISO
IEA 		(PMID:24370996)
GO_REF:0000107 		RGD
Ensembl		 PMID:24370996 GO_REF:0000107 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (PMID:15147274) RGD PMID:15147274 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134 (PMID:23921129) RGD PMID:23921129 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Fcgr2b Fc gamma receptor 2B involved_in IMP
ISO 		PMID:23921129
(PMID:23921129) 		RGD PMID:23921129 PMID:23921129 RGD:12910988 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    response to stimulus 11082
      response to stress 4353
        cellular response to stress 2074
          response to endoplasmic reticulum stress 299
            intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 70
              negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway + 22
              neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + 5
              positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 10
              regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway + 35
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        regulation of cellular process 13032
          signal transduction 7313
            apoptotic signaling pathway 688
              intrinsic apoptotic signaling pathway 349
                intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 70
                  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway + 22
                  neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + 5
                  positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 10
                  regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway + 35
paths to the root