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ONTOLOGY REPORT - ANNOTATIONS


Term:R-loop disassembly
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Accession:GO:0062176 term browser browse the term
Definition:A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability.


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R-loop disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx21 DExD-box helicase 21 involved_in ISO
ISS
(PMID:28790157)
GO_REF:0000024
RGD
UniProt
PMID:28790157 GO_REF:0000024 NCBI chr20:32,213,147...32,232,632
Ensembl chr20:32,213,148...32,232,632
JBrowse link
G Ddx23 DEAD-box helicase 23 involved_in ISO (PMID:28076779) RGD PMID:28076779 NCBI chr 7:140,325,453...140,342,730
Ensembl chr 7:140,325,431...140,342,727
JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO (PMID:30478192) RGD PMID:30478192 NCBI chr16:48,863,385...48,900,409
Ensembl chr16:48,863,418...48,897,795
JBrowse link
G Sirt7 sirtuin 7 involved_in ISS
ISO
GO_REF:0000024
(PMID:28790157)
UniProt
RGD
PMID:28790157 GO_REF:0000024 NCBI chr10:109,796,046...109,802,821
Ensembl chr10:109,796,020...109,802,739
JBrowse link
G Srpk2 SRSF protein kinase 2 involved_in ISO (PMID:28076779) RGD PMID:28076779 NCBI chr 4:7,994,025...8,187,455
Ensembl chr 4:8,066,737...8,185,935
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        cellular macromolecule metabolic process 8243
          DNA metabolic process 882
            R-loop disassembly 5
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      organic substance metabolic process 11337
        organic substance biosynthetic process 6028
          macromolecule biosynthetic process 5089
            cellular macromolecule biosynthetic process 5048
              DNA replication 254
                DNA-dependent DNA replication 152
                  R-loop disassembly 5
paths to the root