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ONTOLOGY REPORT - ANNOTATIONS


Term:R-loop disassembly
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Accession:GO:0062176 term browser browse the term
Definition:A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability.



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R-loop disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx21 DExD-box helicase 21 involved_in ISO
ISS
(PMID:28790157)
GO_REF:0000024
RGD
UniProt
PMID:28790157 GO_REF:0000024 NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543
JBrowse link
G Ddx23 DEAD-box helicase 23 involved_in ISO (PMID:28076779) RGD PMID:28076779 NCBI chr 7:129,797,620...129,814,909
Ensembl chr 7:129,797,614...129,814,949
JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO (PMID:30478192) RGD PMID:30478192 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565
JBrowse link
G Sirt7 sirtuin 7 involved_in ISS
ISO
GO_REF:0000024
(PMID:28790157)
UniProt
RGD
PMID:28790157 GO_REF:0000024 NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172
JBrowse link
G Srpk2 SRSF protein kinase 2 involved_in ISO (PMID:28076779) RGD PMID:28076779 NCBI chr 4:11,464,684...11,655,993
Ensembl chr 4:11,464,674...11,655,990
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    cellular process 17432
      cellular metabolic process 9699
        cellular macromolecule metabolic process 3404
          DNA metabolic process 992
            R-loop disassembly 5
Path 2
Term Annotations click to browse term
  biological_process 18737
    metabolic process 11461
      cellular metabolic process 9699
        heterocycle metabolic process 5481
          nucleobase-containing compound metabolic process 5336
            nucleic acid metabolic process 4845
              DNA metabolic process 992
                DNA replication 276
                  DNA-templated DNA replication 156
                    R-loop disassembly 5
paths to the root