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ONTOLOGY REPORT - ANNOTATIONS

Term:Tapasin-ERp57 complex
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Accession:GO:0061779 term browser browse the term
Definition:Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role.


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Tapasin-ERp57 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdia3 protein disulfide isomerase family A, member 3 part_of IEA
ISO		 GO_REF:0000107
(PMID:19119025)		 Ensembl
RGD		 PMID:19119025 GO_REF:0000107 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Tapbp TAP binding protein part_of ISO (PMID:19119025) RGD PMID:19119025 NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20814
    protein-containing complex 6438
      membrane protein complex 1371
        Tapasin-ERp57 complex 2
Path 2
Term Annotations click to browse term
  cellular_component 20814
    cellular anatomical structure 20574
      intracellular anatomical structure 15184
        intracellular organelle 13599
          intracellular membrane-bounded organelle 12057
            endoplasmic reticulum 1880
              endoplasmic reticulum subcompartment 1064
                endoplasmic reticulum membrane 1054
                  MHC class I peptide loading complex 7
                    Tapasin-ERp57 complex 2
paths to the root