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ONTOLOGY REPORT - ANNOTATIONS


Term:CAMKK-AMPK signaling cascade
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Accession:GO:0061762 term browser browse the term
Definition:A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
Synonyms:related_synonym: stress-activated AMP-activated protein kinase signaling cascade


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CAMKK-AMPK signaling cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 ISO
IEA
(PMID:26103054)
GO_REF:0000107
RGD
Ensembl
PMID:26103054 GO_REF:0000107 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601
JBrowse link
G Irgm immunity-related GTPase M ISO (PMID:25891078) RGD PMID:25891078 NCBI chr10:34,213,885...34,221,968
Ensembl chr10:34,213,936...34,221,928
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO (PMID:26103054) RGD PMID:26103054 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 ISO MGI:MGI:2180033 (MGI:MGI:3797328|PMID:18443001) RGD PMID:18443001 MGI:MGI:3797328 NCBI chr 5:139,982,404...140,015,541
Ensembl chr 5:139,983,680...140,015,541
JBrowse link
negative regulation of CAMKK-AMPK signaling cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egln1 egl-9 family hypoxia-inducible factor 1 IMP RGD PMID:22128786 RGD:11340206 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
positive regulation of CAMKK-AMPK signaling cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:MGI:5906931|PMID:28802038) RGD PMID:28802038 MGI:MGI:5906931 NCBI chr 9:14,611,541...14,618,076
Ensembl chr 9:14,611,561...14,618,013
JBrowse link
regulation of CAMKK-AMPK signaling cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htt huntingtin IEA
ISO
GO_REF:0000107
(PMID:21768291)
Ensembl
RGD
PMID:21768291 GO_REF:0000107 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO (PMID:22012985) RGD PMID:22012985 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    signaling 7580
      signal transduction 7011
        calmodulin dependent kinase signaling pathway 10
          CAMKK-AMPK signaling cascade 8
            negative regulation of CAMKK-AMPK signaling cascade 1
            positive regulation of CAMKK-AMPK signaling cascade 1
            regulation of CAMKK-AMPK signaling cascade + 4
Path 2
Term Annotations click to browse term
  biological_process 20028
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            intracellular signal transduction 2594
              second-messenger-mediated signaling 467
                calcium-mediated signaling 217
                  CAMKK-AMPK signaling cascade 8
                    negative regulation of CAMKK-AMPK signaling cascade 1
                    positive regulation of CAMKK-AMPK signaling cascade 1
                    regulation of CAMKK-AMPK signaling cascade + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.