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ONTOLOGY REPORT - ANNOTATIONS


Term:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
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Accession:GO:0061734 term browser browse the term
Definition:A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule.
Synonyms:exact_synonym: PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization;   Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization


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parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac6 histone deacetylase 6 involved_in ISO UniProtKB:Q9JK66|UniProtKB:Q9Z2V5 (PMID:20457763) RGD PMID:20457763 NCBI chr  X:15,396,185...15,417,486
Ensembl chr  X:15,295,473...15,316,671
Ensembl chr  X:15,295,473...15,316,671
JBrowse link
G Mfn2 mitofusin 2 involved_in ISO (MGI:5498413|PMID:23620051) RGD PMID:23620051 MGI:5498413 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Optn optineurin involved_in ISO
IEA
(PMID:25294927)
GO_REF:0000107
RGD
Ensembl
PMID:25294927 GO_REF:0000107 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO (PMID:19029340) RGD PMID:19029340 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 involved_in ISO (MGI:5298125|PMID:22020285) RGD PMID:22020285 MGI:5298125 NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
JBrowse link
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vps13c vacuolar protein sorting 13 homolog C involved_in ISO
ISS
(PMID:26942284)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:26942284 GO_REF:0000024 NCBI chr 8:73,682,814...73,843,290
Ensembl chr 8:73,682,887...73,842,928
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    cellular process 18457
      process utilizing autophagic mechanism 462
        autophagy 462
          autophagy of mitochondrion 83
            positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 14
              positive regulation of mitophagy in response to mitochondrial depolarization 10
                parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 6
                  negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 1
                  positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 0
                  regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization + 1
Path 2
Term Annotations click to browse term
  biological_process 19612
    cellular process 18457
      cellular component organization or biogenesis 6724
        cellular component organization 6479
          organelle organization 4057
            mitochondrion organization 549
              mitochondrion disassembly 83
                autophagy of mitochondrion 83
                  regulation of autophagy of mitochondrion in response to mitochondrial depolarization 15
                    positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 14
                      positive regulation of mitophagy in response to mitochondrial depolarization 10
                        parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 6
                          negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 1
                          positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 0
                          regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization + 1
paths to the root