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ONTOLOGY REPORT - ANNOTATIONS

Term:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
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Accession:GO:0061734 term browser browse the term
Definition:A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule.
Synonyms:exact_synonym: PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization;   Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization


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parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC6 histone deacetylase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:42,917,911...42,941,894
Ensembl chr  X:42,917,964...42,941,887 		JBrowse link
G MFN2 mitofusin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438 		JBrowse link
G OPTN optineurin involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:48,532,029...48,582,952
Ensembl chr10:48,530,843...48,582,860 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872 		JBrowse link
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 involved_in ISO (MGI:5298125|PMID:22020285) ParkinsonsUK-UCL PMID:22020285 MGI:5298125 NCBI chr 3:6,037,732...6,142,569
Ensembl chr 3:6,037,741...6,142,575 		JBrowse link
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VPS13C vacuolar protein sorting 13 homolog C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:109,931,269...110,105,519
Ensembl chr 1:109,931,264...110,104,241 		JBrowse link
positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VDAC1 voltage dependent anion channel 1 involved_in ISO (PMID:32047033) UniProt PMID:32047033 NCBI chr 2:136,302,188...136,334,461
Ensembl chr 2:136,302,191...136,396,301 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17799
    cellular process 16838
      process utilizing autophagic mechanism 512
        autophagy 512
          macroautophagy 307
            mitophagy 72
              positive regulation of mitophagy in response to mitochondrial depolarization 11
                parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 7
                  negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 1
                  positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 1
                  regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization + 2
Path 2
Term Annotations click to browse term
  biological_process 17799
    cellular process 16838
      cellular component organization or biogenesis 6723
        cellular component organization 6509
          organelle organization 3633
            organelle disassembly 171
              autophagy of mitochondrion 79
                regulation of autophagy of mitochondrion in response to mitochondrial depolarization 16
                  positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization 15
                    positive regulation of mitophagy in response to mitochondrial depolarization 11
                      parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 7
                        negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 1
                        positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization 1
                        regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization + 2
paths to the root