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ONTOLOGY REPORT - ANNOTATIONS


Term:inflammasome complex
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Accession:GO:0061702 term browser browse the term
Definition:A cytosolic protein complex that is capable of activating caspase-1.



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inflammasome complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 located_in ISO (PMID:16037825) RGD PMID:16037825 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Mefv MEFV innate immuity regulator, pyrin located_in ISO (PMID:16037825) RGD PMID:16037825 NCBI chr10:11,786,948...11,796,977
Ensembl chr10:11,787,422...11,796,973
JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 part_of IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398
JBrowse link
G Nlrp14 NLR family, pyrin domain containing 14 part_of IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 1:161,069,141...161,089,158
Ensembl chr 1:161,061,165...161,089,222
JBrowse link
G Nlrp2 NLR family pyrin domain containing 2 part_of IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 1:69,515,505...69,554,689
Ensembl chr 1:69,515,505...69,554,454
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 part_of ISO
IEA
(MGI:6453663|PMID:30248149)
GO_REF:0000044
RGD
UniProt
PMID:30248149 GO_REF:0000044 MGI:6453663 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nlrp4 NLR family, pyrin domain containing 4 part_of IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 1:68,089,321...68,132,429
Ensembl chr 1:68,089,321...68,127,521
JBrowse link
G Nlrp4b NLR family, pyrin domain containing 4B part_of IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 1:70,426,021...70,457,919
Ensembl chr 1:70,426,161...70,457,919
JBrowse link
G Nlrp5 NLR family, pyrin domain containing 5 part_of IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 1:67,778,037...67,810,946
Ensembl chr 1:67,777,948...68,023,736
JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 part_of ISO (MGI:6453663|PMID:30248149) RGD PMID:30248149 MGI:6453663 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113
JBrowse link
G Nlrp9 NLR family, pyrin domain containing 9 part_of ISO (PMID:28636595) RGD PMID:28636595 NCBI chr 1:68,291,180...68,341,512
Ensembl chr 1:68,291,180...68,341,512
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 part_of IEA GO_REF:0000044 UniProt GO_REF:0000044 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Pycard PYD and CARD domain containing part_of
located_in
ISO (MGI:6453663|PMID:30248149)
(PMID:16037825)
RGD PMID:16037825 PMID:30248149 MGI:6453663 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
AIM2 inflammasome complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aim2 absent in melanoma 2 part_of
located_in
ISO
IBA
(PMID:19158676), (PMID:19158679)
(PMID:24630722)
PMID:21873635
(MGI:3836373|PMID:19158679)
RGD PMID:19158676 PMID:19158679 PMID:24630722 PMID:21873635 MGI:3836373, RGD:13792537 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975
JBrowse link
G Casp1 caspase 1 part_of
located_in
ISS
ISO
IEA
IBA
GO_REF:0000024
(PMID:24630722)
GO_REF:0000107
(PMID:19158676)
PMID:21873635
UniProt
RGD
Ensembl
PMID:19158676 PMID:24630722 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp4 caspase 4 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Pycard PYD and CARD domain containing part_of
located_in
ISO (PMID:19158676)
(PMID:24630722)
RGD PMID:19158676 PMID:24630722 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
CARD8 inflammasome complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nlrp1b NLR family, pyrin domain containing 1B part_of
is_active_in
ISO (PMID:33420028), (PMID:33420033)
(PMID:32840892), (PMID:33542150)
RGD PMID:32840892 PMID:33420028 PMID:33420033 PMID:33542150 NCBI chr10:55,838,381...55,904,374 JBrowse link
IPAF inflammasome complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 part_of IEA
ISO
ISS
IBA
GO_REF:0000107
(MGI:5289703|PMID:21874021)
GO_REF:0000024
PMID:21873635
Ensembl
RGD
UniProt
PMID:21874021 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5289703, RGD:13792537 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp4 caspase 4 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Naip2 NLR family, apoptosis inhibitory protein 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 2:31,507,424...31,570,542 JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 part_of ISO (MGI:5289703|PMID:21874021) RGD PMID:21874021 MGI:5289703 NCBI chr 2:31,507,423...31,559,098 JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 part_of ISS
ISO
GO_REF:0000024
(MGI:5289703|PMID:21874021), (MGI:5444805|PMID:22885697)
UniProt
RGD
PMID:21874021 PMID:22885697 GO_REF:0000024 MGI:5289703 MGI:5444805 NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248
JBrowse link
NLRP1 inflammasome complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 part_of
located_in
ISS
ISO
IEA
GO_REF:0000024
(PMID:17349957)
(PMID:12191486)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:12191486 PMID:17349957 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A part_of
located_in
ISO
ISS
(PMID:12191486), (PMID:30291141), (PMID:33420028), (PMID:33420033)
(PMID:17349957)
GO_REF:0000024
RGD
UniProt
PMID:12191486 PMID:17349957 PMID:30291141 PMID:33420028 PMID:33420033 GO_REF:0000024 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180
JBrowse link
G Pycard PYD and CARD domain containing part_of
located_in
ISO (PMID:12191486)
(PMID:17349957)
RGD PMID:12191486 PMID:17349957 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
NLRP3 inflammasome complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 part_of
located_in
IEA
ISO
IBA
ISS
GO_REF:0000107
(PMID:29255148)
PMID:21873635
GO_REF:0000024
(PMID:15030775)
Ensembl
RGD
UniProt
PMID:15030775 PMID:29255148 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp4 caspase 4 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked part_of ISO (MGI:6368386|PMID:31511697) RGD PMID:31511697 MGI:6368386 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Dhx33 DEAH-box helicase 33 part_of ISO (PMID:23871209) RGD PMID:23871209 NCBI chr10:55,708,102...55,724,618
Ensembl chr10:55,705,756...55,724,567
JBrowse link
G Gsdmd gasdermin D part_of IBA
ISO
PMID:21873635
(MGI:5751630|PMID:26611636)
RGD PMID:26611636 PMID:21873635 MGI:5751630, RGD:13792537 NCBI chr 7:107,542,242...107,547,052
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Nlrp1b NLR family, pyrin domain containing 1B part_of ISO (PMID:15030775) RGD PMID:15030775 NCBI chr10:55,838,381...55,904,374 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 part_of
located_in
ISO (PMID:15030775)
(PMID:29255148)
(MGI:5790524|PMID:27374331)
RGD PMID:15030775 PMID:27374331 PMID:29255148 MGI:5790524 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Pycard PYD and CARD domain containing part_of
located_in
ISO (PMID:15030775)
(PMID:29255148)
RGD PMID:15030775 PMID:29255148 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19969
    protein-containing complex 6165
      inflammasome complex 24
        AIM2 inflammasome complex 5
        CARD8 inflammasome complex 1
        IPAF inflammasome complex 6
        NLRP1 inflammasome complex 3
        NLRP3 inflammasome complex 9
Path 2
Term Annotations click to browse term
  cellular_component 19969
    cellular anatomical entity 19676
      intracellular anatomical structure 14364
        cytoplasm 11373
          cytosol 4227
            inflammasome complex 24
              AIM2 inflammasome complex 5
              CARD8 inflammasome complex 1
              IPAF inflammasome complex 6
              NLRP1 inflammasome complex 3
              NLRP3 inflammasome complex 9
paths to the root