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ONTOLOGY REPORT - ANNOTATIONS


Term:GATOR2 complex
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Accession:GO:0061700 term browser browse the term
Definition:A multiprotein subcomplex of GATOR that regulates mTOR signaling by interacting with the Rag GTPases. In humans this complex consists of Mios, WDR24, WDR59, Seh1L, Sec13.


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GATOR2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 colocalizes_with ISO
IBA
ISS
(PMID:26972053)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:26972053, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr14:84,447,552...84,457,396
Ensembl chr14:84,447,885...84,452,367
JBrowse link
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 colocalizes_with ISO
IBA
(PMID:26972053)
PMID:21873635
RGD PMID:26972053, PMID:21873635 RGD:13792537 NCBI chr12:25,595,800...25,638,806
Ensembl chr12:25,601,404...25,638,797
JBrowse link
G Mios meiosis regulator for oocyte development ISO (PMID:23723238) RGD PMID:23723238 NCBI chr 4:34,238,370...34,264,015
Ensembl chr 4:34,237,762...34,264,015
JBrowse link
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component ISO (PMID:23723238) RGD PMID:23723238 NCBI chr 4:145,686,186...145,699,577
Ensembl chr 4:145,686,193...145,699,577
JBrowse link
G Seh1l SEH1-like nucleoporin ISO (PMID:23723238) RGD PMID:23723238 NCBI chr18:63,545,150...63,568,101 JBrowse link
G Sesn1 sestrin 1 colocalizes_with ISO
IBA
(PMID:25263562), (PMID:26449471)
PMID:21873635
RGD PMID:25263562, PMID:26449471, PMID:21873635 RGD:13792537 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sesn2 sestrin 2 colocalizes_with ISO
IBA
(PMID:25263562), (PMID:25457612), (PMID:26449471), (PMID:26586190), (PMID:26612684)
PMID:21873635
RGD PMID:25263562, PMID:25457612, PMID:26449471, PMID:26586190, PMID:26612684, PMID:21873635 RGD:13792537 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sesn3 sestrin 3 colocalizes_with ISO
IBA
(PMID:25263562), (PMID:26449471)
PMID:21873635
RGD PMID:25263562, PMID:26449471, PMID:21873635 RGD:13792537 NCBI chr 8:12,823,060...12,878,749
Ensembl chr 8:12,823,155...12,872,705
JBrowse link
G Szt2 SZT2 subunit of KICSTOR complex colocalizes_with ISO (PMID:28199306), (PMID:28199315) RGD PMID:28199306, PMID:28199315 NCBI chr 5:137,192,120...137,238,384
Ensembl chr 5:137,190,875...137,238,354
JBrowse link
G Wdr24 WD repeat domain 24 ISO (PMID:23723238) RGD PMID:23723238 NCBI chr10:15,191,078...15,195,860
Ensembl chr10:15,191,078...15,195,860
JBrowse link
G Wdr59 WD repeat domain 59 ISO (PMID:23723238) RGD PMID:23723238 NCBI chr19:43,651,686...43,714,391
Ensembl chr19:43,651,148...43,714,418
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6092
      GATOR2 complex 11
Path 2
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6092
      Seh1-associated complex 16
        GATOR2 complex 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.