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ONTOLOGY REPORT - ANNOTATIONS


Term:GATOR2 complex
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Accession:GO:0061700 term browser browse the term
Definition:A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins.
Comment:The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131.
Synonyms:exact_synonym: SEACAT complex


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GATOR2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 colocalizes_with ISO
ISS
(PMID:26972053)
GO_REF:0000024
RGD
UniProt
PMID:26972053 GO_REF:0000024 NCBI chr14:79,086,136...79,090,549
Ensembl chr14:79,086,136...79,090,548
JBrowse link
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 colocalizes_with
part_of
ISO
IEA
(PMID:26972053)
GO_REF:0000107
RGD
Ensembl
PMID:26972053 GO_REF:0000107 NCBI chr12:22,577,504...22,620,182
Ensembl chr12:22,577,512...22,620,182
JBrowse link
G Mios meiosis regulator for oocyte development part_of ISO (PMID:23723238) RGD PMID:23723238 NCBI chr 4:36,263,419...36,289,546
Ensembl chr 4:36,263,968...36,289,544
JBrowse link
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component part_of ISO (PMID:23723238) RGD PMID:23723238 NCBI chr 4:146,877,739...146,891,130
Ensembl chr 4:146,875,524...146,891,173
JBrowse link
G Seh1l SEH1-like nucleoporin part_of ISO (PMID:23723238) RGD PMID:23723238
G Sesn1 sestrin 1 colocalizes_with
part_of
ISO
IEA
(PMID:25263562), (PMID:26449471)
GO_REF:0000107
RGD
Ensembl
PMID:25263562 PMID:26449471 GO_REF:0000107 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
JBrowse link
G Sesn3 sestrin 3 colocalizes_with
part_of
ISO
IEA
(PMID:25263562), (PMID:26449471)
GO_REF:0000107
RGD
Ensembl
PMID:25263562 PMID:26449471 GO_REF:0000107 NCBI chr 8:11,133,822...11,189,436
Ensembl chr 8:11,133,678...11,185,842
JBrowse link
G Szt2 SZT2 subunit of KICSTOR complex colocalizes_with
part_of
ISO
IEA
(PMID:28199306), (PMID:28199315)
GO_REF:0000107
RGD
Ensembl
PMID:28199306 PMID:28199315 GO_REF:0000107 NCBI chr 5:131,897,250...131,943,953
Ensembl chr 5:131,897,275...131,943,904
JBrowse link
G Wdr24 WD repeat domain 24 part_of ISO (PMID:23723238) RGD PMID:23723238 NCBI chr10:14,844,089...14,848,871
Ensembl chr10:14,843,728...14,848,864
JBrowse link
G Wdr59 WD repeat domain 59 part_of ISO (PMID:23723238) RGD PMID:23723238 NCBI chr19:39,416,432...39,483,773
Ensembl chr19:39,416,429...39,483,698
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20010
    protein-containing complex 6011
      GATOR2 complex 10
Path 2
Term Annotations click to browse term
  cellular_component 20010
    protein-containing complex 6011
      Seh1-associated complex 15
        GATOR2 complex 10
paths to the root