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ONTOLOGY REPORT - ANNOTATIONS

Term:chaperone-mediated autophagy
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Accession:GO:0061684 term browser browse the term
Definition:The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded.
Synonyms:exact_synonym: CASA;   chaperone-assisted selective autophagy
 related_synonym: CMA
 xref: Wikipedia:Chaperone-mediated_autophagy


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chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 involved_in NAS PMID:18644871 ParkinsonsUK-UCL PMID:18644871 RGD:10412301 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 involved_in NAS PMID:18644871 ParkinsonsUK-UCL PMID:18644871 RGD:10412301 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in
acts_upstream_of_or_within		 IDA
IGI		 PMID:18644871 ParkinsonsUK-UCL
MGI		 PMID:18644871 PMID:18644871 RGD:10412301, RGD:10412301 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in
acts_upstream_of_or_within		 IDA
ISO		 PMID:11082038
(PMID:36586411)
UniProtKB:P13473 (MGI:3813410|PMID:18644871), (MGI:5805578|PMID:27628032)
(MGI:3813419|PMID:18579532)
(PMID:24880125), (PMID:27628032)
(PMID:8662539)		 RGD PMID:8662539 PMID:18579532 PMID:18644871 PMID:24880125 PMID:27628032 More... MGI:3813410 MGI:3813419 MGI:5805578, RGD:1581607 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Synpo2 synaptopodin 2 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr 2:211,217,099...211,371,267
Ensembl chr 2:211,216,783...211,371,267 		JBrowse link
negative regulation of chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsa cathepsin A involved_in ISO UniProtKB:P10619 (PMID:12505983)
(MGI:5700310|PMID:12505983)		 RGD PMID:12505983 MGI:5700310 NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215 		JBrowse link
G Snca synuclein alpha involved_in ISO
IEA		 (PMID:20697033)
GO_REF:0000107		 RGD
Ensembl		 PMID:20697033 GO_REF:0000107 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
positive regulation of chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plk3 polo-like kinase 3 involved_in ISO (PMID:27344333) RGD PMID:27344333 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
protein targeting to lysosome involved in chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clu clusterin involved_in ISO
IEA		 (PMID:9228033)
GO_REF:0000107		 RGD
Ensembl		 PMID:9228033 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Hsc70-ps1 heat shock cognate protein 70, pseudogene 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:164,044,226...164,046,344
Ensembl chr 2:164,044,261...164,046,336 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in ISS
ISO
IBA		 GO_REF:0000024
(PMID:11559757), (PMID:26212789), (PMID:36586411)
PMID:21873635		 UniProt
RGD		 PMID:11559757 PMID:26212789 PMID:36586411 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA
IGI
IMP
ISS		 (PMID:27628032)
GO_REF:0000107
PMID:21873635
PMID:18644871
(MGI:5805578|PMID:27628032)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27628032 PMID:21873635 PMID:18644871 PMID:18644871 GO_REF:0000024 GO_REF:0000107 MGI:5805578, RGD:13792537, RGD:10412301, RGD:10412301 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
regulation of chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfap glial fibrillary acidic protein involved_in ISO
IMP
IBA		 (PMID:20797626)
(MGI:4830420|PMID:20797626)
PMID:21873635		 RGD PMID:20797626 PMID:20797626 PMID:21873635 MGI:4830420, RGD:10412296, RGD:13792537 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    cellular process 18233
      process utilizing autophagic mechanism 503
        autophagy 503
          chaperone-mediated autophagy 14
            chaperone-mediated autophagy translocation complex assembly 0
            negative regulation of chaperone-mediated autophagy 2
            positive regulation of chaperone-mediated autophagy 1
            protein targeting to lysosome involved in chaperone-mediated autophagy 4
            regulation of chaperone-mediated autophagy + 4
Path 2
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      organic substance metabolic process 10895
        macromolecule metabolic process 9164
          protein metabolic process 4578
            protein catabolic process 1021
              chaperone-mediated autophagy 14
                chaperone-mediated autophagy translocation complex assembly 0
                negative regulation of chaperone-mediated autophagy 2
                positive regulation of chaperone-mediated autophagy 1
                protein targeting to lysosome involved in chaperone-mediated autophagy 4
                regulation of chaperone-mediated autophagy + 4
paths to the root