Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:chaperone-mediated autophagy
go back to main search page
Accession:GO:0061684 term browser browse the term
Definition:The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded.
Synonyms:exact_synonym: CASA;   chaperone-assisted selective autophagy
 related_synonym: CMA
 xref: Wikipedia:Chaperone-mediated_autophagy



show annotations for term's descendants           Sort by:
 
chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg5 autophagy related 5 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Bag3 BAG cochaperone 3 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 involved_in NAS PMID:18644871 ParkinsonsUK-UCL PMID:18644871 RGD:10412301 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 involved_in NAS PMID:18644871 ParkinsonsUK-UCL PMID:18644871 RGD:10412301 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in
acts_upstream_of_or_within
IDA
IGI
PMID:18644871 ParkinsonsUK-UCL
MGI
PMID:18644871 PMID:18644871 RGD:10412301, RGD:10412301 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in
acts_upstream_of_or_within
IDA
ISO
PMID:11082038
UniProtKB:P13473 (MGI:3813410|PMID:18644871), (MGI:5805578|PMID:27628032)
(MGI:3813419|PMID:18579532)
(PMID:24880125), (PMID:27628032)
(PMID:8662539)
RGD PMID:8662539 PMID:18579532 PMID:18644871 PMID:24880125 PMID:27628032 More... MGI:3813410 MGI:3813419 MGI:5805578, RGD:1581607 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046
JBrowse link
G Synpo2 synaptopodin 2 involved_in IMP PMID:23434281 ARUK-UCL PMID:23434281 RGD:12793031 NCBI chr 2:211,217,099...211,371,267
Ensembl chr 2:211,216,783...211,371,267
JBrowse link
negative regulation of chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsa cathepsin A involved_in ISO
ISS
NAS
UniProtKB:P10619 (PMID:12505983)
(MGI:5700310|PMID:12505983)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:12505983 PMID:12505983 GO_REF:0000024 MGI:5700310, RGD:10412300 NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215
JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:20697033) RGD PMID:20697033 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
positive regulation of chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plk3 polo-like kinase 3 involved_in ISO (PMID:27344333) RGD PMID:27344333 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
protein targeting to lysosome involved in chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07011951.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G AABR07033324.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr11:17,466,782...17,468,721 JBrowse link
G AABR07048992.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Clu clusterin involved_in ISO
IEA
(PMID:9228033)
GO_REF:0000107
RGD
Ensembl
PMID:9228033 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in IBA
ISO
PMID:21873635
(PMID:26212789)
RGD PMID:26212789 PMID:21873635 RGD:13792537 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in
acts_upstream_of_or_within
ISO
IGI
IMP
IBA
ISS
(PMID:27628032)
PMID:18644871
PMID:21873635
(MGI:5805578|PMID:27628032)
GO_REF:0000024
RGD
UniProt
PMID:27628032 PMID:18644871 PMID:18644871 PMID:21873635 GO_REF:0000024 MGI:5805578, RGD:10412301, RGD:10412301, RGD:13792537 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G LOC680121 similar to heat shock protein 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:5,628,432...5,630,535
Ensembl chr11:5,628,427...5,630,533
JBrowse link
regulation of chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfap glial fibrillary acidic protein involved_in ISO
IMP
(PMID:20797626)
(MGI:4830420|PMID:20797626)
RGD PMID:20797626 PMID:20797626 MGI:4830420, RGD:10412296 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19391
    cellular process 18252
      process utilizing autophagic mechanism 456
        autophagy 456
          chaperone-mediated autophagy 18
            chaperone-mediated autophagy translocation complex assembly 0
            negative regulation of chaperone-mediated autophagy 2
            positive regulation of chaperone-mediated autophagy 1
            protein targeting to lysosome involved in chaperone-mediated autophagy 7
            regulation of chaperone-mediated autophagy + 4
Path 2
Term Annotations click to browse term
  biological_process 19391
    metabolic process 11735
      organic substance metabolic process 11277
        macromolecule metabolic process 9736
          protein metabolic process 5848
            protein catabolic process 1002
              chaperone-mediated autophagy 18
                chaperone-mediated autophagy translocation complex assembly 0
                negative regulation of chaperone-mediated autophagy 2
                positive regulation of chaperone-mediated autophagy 1
                protein targeting to lysosome involved in chaperone-mediated autophagy 7
                regulation of chaperone-mediated autophagy + 4
paths to the root