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ONTOLOGY REPORT - ANNOTATIONS


Term:spontaneous neurotransmitter secretion
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Accession:GO:0061669 term browser browse the term
Definition:Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential.
Synonyms:exact_synonym: stimulus-independent neurotransmitter secretion


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spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Doc2a double C2 domain alpha ISO (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chrNW_004936501:12,458,537...12,463,857 JBrowse link
G Doc2b double C2 domain beta ISO (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chrNW_004936538:7,461,030...7,486,648 JBrowse link
G LOC101974478 protein unc-13 homolog B ISO PMID:21262469 ParkinsonsUK-UCL PMID:21262469 RGD:10047275 NCBI chrNW_004936524:3,320,859...3,369,865 JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 ISO (MGI:MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:MGI:4887275 NCBI chrNW_004936618:3,678,400...4,047,994 JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 ISO (MGI:MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:MGI:4887275 NCBI chrNW_004936470:39,725,092...40,270,268 JBrowse link
G Rph3a rabphilin 3A ISO (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chrNW_004936668:2,827,574...2,911,955 JBrowse link
G Stx1b syntaxin 1B ISO (MGI:MGI:3803800|PMID:18703708)
(MGI:MGI:5521403|PMID:24133272)
ParkinsonsUK-UCL PMID:18703708, PMID:24133272 MGI:MGI:3803800, MGI:MGI:5521403 NCBI chrNW_004936501:13,370,678...13,378,933 JBrowse link
G Syt1 synaptotagmin 1 ISO (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chrNW_004936698:65,210...575,538 JBrowse link
negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r9a protein phosphatase 1 regulatory subunit 9A ISO RGD PMID:16899074 RGD:10002752 NCBI chrNW_004936585:4,981,555...5,277,185 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:22314364) ParkinsonsUK-UCL PMID:22314364 NCBI chrNW_004936489:12,118,538...12,913,664 JBrowse link
positive regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stx1b syntaxin 1B ISO (MGI:MGI:5603022|PMID:24587181) ParkinsonsUK-UCL PMID:24587181 MGI:MGI:5603022 NCBI chrNW_004936501:13,370,678...13,378,933 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11998
    biological regulation 8793
      regulation of biological quality 3395
        regulation of neurotransmitter levels 223
          neurotransmitter secretion 169
            spontaneous neurotransmitter secretion 10
              negative regulation of spontaneous neurotransmitter secretion 2
              positive regulation of spontaneous neurotransmitter secretion 1
              regulation of spontaneous neurotransmitter secretion + 3
Path 2
Term Annotations click to browse term
  biological_process 11998
    cellular process 11174
      cell communication 4239
        cell-cell signaling 1344
          synaptic signaling 654
            trans-synaptic signaling 633
              anterograde trans-synaptic signaling 625
                chemical synaptic transmission 625
                  spontaneous synaptic transmission 16
                    spontaneous neurotransmitter secretion 10
                      negative regulation of spontaneous neurotransmitter secretion 2
                      positive regulation of spontaneous neurotransmitter secretion 1
                      regulation of spontaneous neurotransmitter secretion + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.