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ONTOLOGY REPORT - ANNOTATIONS

Term:protein localization to lysosome
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Accession:GO:0061462 term browser browse the term
Definition:A process in which a protein is transported to, or maintained in, a location within a lysosome.


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protein localization to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP13A2 ATPase cation transporting 13A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:81,196,355...81,215,736
Ensembl chr 2:81,196,463...81,215,689 		JBrowse link
G CD81 CD81 molecule involved_in ISO (PMID:25635054) BHF-UCL PMID:25635054 NCBI chr18:46,466,484...46,474,236
Ensembl chr18:46,466,499...46,473,868 		JBrowse link
G GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25592972) Ensembl
MGI		 PMID:25592972 GO_REF:0000107 NCBI chr 9:5,235,377...5,250,982
Ensembl chr 9:5,235,025...5,249,361 		JBrowse link
G GLMP glycosylated lysosomal membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:41,588,024...41,590,857
Ensembl chr 7:41,588,075...41,590,555 		JBrowse link
G KICS2 KICSTOR subunit 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:6,977,602...6,998,204
Ensembl chr10:6,979,624...6,998,138 		JBrowse link
G KPTN kaptin, actin binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:108,535,140...108,544,405
Ensembl chr 1:108,535,681...108,543,164 		JBrowse link
G LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:9,372,728...9,376,047
Ensembl chr 6:9,372,715...9,375,945 		JBrowse link
G LAPTM5 lysosomal protein transmembrane 5 involved_in ISO (MGI:5444793|PMID:22949502) ARUK-UCL PMID:22949502 MGI:5444793 NCBI chr 2:70,188,382...70,215,361
Ensembl chr 2:70,152,739...70,333,073 		JBrowse link
G LMBRD1 LMBR1 domain containing 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:32,274,056...32,383,737
Ensembl chr12:32,274,412...32,383,578 		JBrowse link
G LOC102156380 ragulator complex protein LAMTOR5-like involved_in ISO (PMID:22980980) UniProt PMID:22980980 NCBI chr 9:53,420,574...53,421,161 JBrowse link
G MFSD1 major facilitator superfamily domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:25,069,701...25,094,196
Ensembl chr34:25,069,696...25,092,386 		JBrowse link
G RRAGA Ras related GTP binding A involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:38,886,990...38,888,634
Ensembl chr11:38,886,397...38,888,184 		JBrowse link
G RRAGC Ras related GTP binding C involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:3,875,193...3,892,501
Ensembl chr15:3,874,116...3,892,504 		JBrowse link
G RTN4 reticulon 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:55,884,452...55,954,476
Ensembl chr10:55,885,125...55,936,574 		JBrowse link
G SH3BP4 SH3 domain binding protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:46,049,631...46,133,065
Ensembl chr25:46,049,475...46,155,519 		JBrowse link
G SZT2 SZT2 subunit of KICSTOR complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:16,729,068...16,780,549
Ensembl chr15:16,728,758...16,780,325 		JBrowse link
N-glycan processing to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNPTAB N-acetylglucosamine-1-phosphate transferase subunits alpha and beta involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:40,659,108...40,724,498
Ensembl chr15:40,631,279...40,704,365 		JBrowse link
G GNPTAB N-acetylglucosamine-1-phosphate transferase subunits alpha and beta involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:40,630,976...40,641,398
Ensembl chr15:40,631,279...40,704,365 		JBrowse link
negative regulation of protein localization to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,931,786...8,012,484
Ensembl chr17:7,934,739...8,178,707 		JBrowse link
neurotransmitter receptor transport, postsynaptic endosome to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3D1 adaptor related protein complex 3 subunit delta 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:56,893,479...56,932,460
Ensembl chr20:56,893,535...56,931,830 		JBrowse link
G CACNG2 calcium voltage-gated channel auxiliary subunit gamma 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:27,750,314...27,862,646
Ensembl chr10:27,750,935...27,862,885 		JBrowse link
G CACNG3 calcium voltage-gated channel auxiliary subunit gamma 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:21,626,977...21,712,331
Ensembl chr 6:21,627,547...21,711,635 		JBrowse link
G CACNG4 calcium voltage-gated channel auxiliary subunit gamma 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:13,449,465...13,464,296
Ensembl chr 9:13,449,450...13,462,645 		JBrowse link
G CACNG5 calcium voltage-gated channel auxiliary subunit gamma 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:13,575,902...13,587,818
Ensembl chr 9:13,578,805...13,615,233 		JBrowse link
G CACNG7 calcium voltage-gated channel auxiliary subunit gamma 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:103,276,743...103,293,393
Ensembl chr 1:103,277,662...103,293,995 		JBrowse link
G CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:103,245,102...103,263,154
Ensembl chr 1:103,250,132...103,263,178 		JBrowse link
G RAB7A RAB7A, member RAS oncogene family involved_in ISO (PMID:24217640) SynGO PMID:24217640 NCBI chr20:2,704,716...2,776,518
Ensembl chr20:2,704,752...2,826,636 		JBrowse link
positive regulation of protein localization to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPR137B G protein-coupled receptor 137B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:3,819,338...3,864,690
Ensembl chr 4:3,825,602...3,864,780 		JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:25,981,170...25,986,942
Ensembl chr21:25,981,254...25,996,432 		JBrowse link
G MEAK7 MTOR associated protein, eak-7 homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:67,958,596...67,976,945
Ensembl chr 5:67,962,242...67,975,264 		JBrowse link
protein targeting to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3B1 adaptor related protein complex 3 subunit beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14557411) Ensembl
MGI		 PMID:14557411 GO_REF:0000107 NCBI chr 3:28,481,974...28,748,095
Ensembl chr 3:28,481,038...28,751,258 		JBrowse link
G AP4M1 adaptor related protein complex 4 subunit mu 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:9,488,496...9,492,703
Ensembl chr 6:9,486,372...9,492,243 		JBrowse link
G GCC2 GRIP and coiled-coil domain containing 2 involved_in ISO (PMID:16885419) UniProt PMID:16885419 NCBI chr10:35,379,055...35,431,500
Ensembl chr10:35,379,030...35,431,457 		JBrowse link
G GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:5,235,377...5,250,982
Ensembl chr 9:5,235,025...5,249,361 		JBrowse link
G HGS hepatocyte growth factor-regulated tyrosine kinase substrate involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:499,071...513,375
Ensembl chr 9:499,116...514,308 		JBrowse link
G LAPTM5 lysosomal protein transmembrane 5 involved_in ISO (MGI:3803048|PMID:18619870) ARUK-UCL PMID:18619870 MGI:3803048 NCBI chr 2:70,188,382...70,215,361
Ensembl chr 2:70,152,739...70,333,073 		JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor ISO chorionic gonadotropin after receptor internalization RGD PMID:10847593 RGD:2292601 NCBI chr10:50,540,706...50,594,336
Ensembl chr10:50,541,960...50,598,036 		JBrowse link
G M6PR mannose-6-phosphate receptor, cation dependent involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr27:36,787,745...36,796,194
Ensembl chr27:36,786,981...36,796,770 		JBrowse link
G NCOA4 nuclear receptor coactivator 4 acts_upstream_of_or_within ISO (PMID:25327288) MGI PMID:25327288 NCBI chr28:1,801,655...1,867,705
Ensembl chr28:1,802,678...1,825,020 		JBrowse link
G NDP norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO (PMID:28675177) MGI PMID:28675177 NCBI chr  X:37,949,560...37,975,573
Ensembl chr  X:37,950,489...37,975,346 		JBrowse link
G NEDD4 NEDD4 E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:21,123,333...21,229,907
Ensembl chr30:21,126,043...21,229,870 		JBrowse link
G RAB7A RAB7A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:2,704,716...2,776,518
Ensembl chr20:2,704,752...2,826,636 		JBrowse link
G SCARB2 scavenger receptor class B member 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr32:788,117...865,496
Ensembl chr32:790,379...865,502 		JBrowse link
G SNX16 sorting nexin 16 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr29:28,882,768...28,922,713
Ensembl chr29:28,884,426...28,920,797 		JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:12,493,750...12,650,530
Ensembl chr 5:12,431,377...12,650,784 		JBrowse link
G SORT1 sortilin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19732768) Ensembl
MGI		 PMID:19732768 GO_REF:0000107 NCBI chr 6:42,454,091...42,521,251
Ensembl chr 6:42,453,942...42,516,740 		JBrowse link
G VPS4A vacuolar protein sorting 4 homolog A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:80,327,059...80,340,380 JBrowse link
G VPS53 VPS53 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:45,074,066...45,239,569
Ensembl chr 9:45,074,100...45,214,066 		JBrowse link
G VPS54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:63,598,373...63,676,753
Ensembl chr10:63,599,229...63,676,747 		JBrowse link
G WASHC1 WASH complex subunit 1 involved_in ISO (PMID:20175130) UniProt PMID:20175130 NCBI chr27:42,102,694...42,118,850
Ensembl chr27:42,099,886...42,116,339 		JBrowse link
G ZFYVE16 zinc finger FYVE-type containing 16 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:26,662,750...26,714,184
Ensembl chr 3:26,664,068...26,699,073 		JBrowse link
protein targeting to lysosome involved in chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:11,292,219...11,296,851
Ensembl chr 5:11,292,262...11,296,797 		JBrowse link
G LAMP2 lysosomal associated membrane protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 PMID:18644871 MGI
TreeGrafter
Ensembl		 PMID:18644871 GO_REF:0000107 GO_REF:0000118 RGD:10412301 NCBI chr  X:92,405,946...92,444,527
Ensembl chr  X:92,407,950...92,444,765 		JBrowse link
G LOC119873859 heat shock cognate 71 kDa protein-like involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118
G LOC476082 heat shock cognate 71 kDa protein-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:9,905,115...9,907,262 JBrowse link
G LOC607182 heat shock cognate 71 kDa protein-like involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    localization 5609
      macromolecule localization 3127
        cellular macromolecule localization 2660
          protein localization 2648
            protein localization to organelle 1073
              protein localization to vacuole 90
                protein localization to lysosome 55
                  negative regulation of protein localization to lysosome 2
                  neurotransmitter receptor transport, postsynaptic endosome to lysosome 8
                  positive regulation of protein localization to lysosome 3
                  protein targeting to lysosome + 29
                  regulation of protein localization to lysosome + 5
paths to the root