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ONTOLOGY REPORT - ANNOTATIONS


Term:protein localization to lysosome
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Accession:GO:0061462 term browser browse the term
Definition:A process in which a protein is transported to, or maintained in, a location within a lysosome.



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protein localization to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP13A2 ATPase cation transporting 13A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:15,929,613...15,955,631
Ensembl chr 1:16,986,385...17,006,033
Ensembl chr 1:16,986,385...17,006,033
JBrowse link
G CD81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,400,503...2,421,132
Ensembl chr11:2,437,991...2,449,308
JBrowse link
G GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5751042|PMID:25592972) MGI
Ensembl
PMID:25592972 GO_REF:0000107 MGI:5751042 NCBI chr17:69,185,045...69,208,766
Ensembl chr17:74,737,164...74,762,039
JBrowse link
G GLMP glycosylated lysosomal membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:131,635,614...131,638,610
Ensembl chr 1:135,465,671...135,468,666
JBrowse link
G KICS2 KICSTOR subunit 2 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr12:24,691,658...24,721,618
Ensembl chr12:25,174,580...25,219,830
JBrowse link
G KPTN kaptin, actin binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:44,467,344...44,478,150
Ensembl chr19:53,122,663...53,131,805
JBrowse link
G LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 involved_in ISO (PMID:22980980) UniProt PMID:22980980 NCBI chr 7:92,183,617...92,188,967
Ensembl chr 7:105,616,074...105,621,685
JBrowse link
G LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 involved_in ISO (PMID:22980980) UniProt PMID:22980980 NCBI chr 1:113,050,671...113,057,368
Ensembl chr 1:127,285,553...127,292,233
JBrowse link
G LAPTM5 lysosomal protein transmembrane 5 involved_in ISO (MGI:5444793|PMID:22949502) ARUK-UCL PMID:22949502 MGI:5444793 NCBI chr 1:30,005,941...30,031,366
Ensembl chr 1:31,032,963...31,058,385
JBrowse link
G LMBRD1 LMBR1 domain containing 1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 6:67,515,861...67,638,039
Ensembl chr 6:70,814,770...70,937,116
JBrowse link
G MFSD1 major facilitator superfamily domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:155,758,133...155,899,272
Ensembl chr 3:163,878,833...163,903,955
JBrowse link
G RRAGA Ras related GTP binding A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:18,868,781...18,870,356
Ensembl chr 9:19,362,599...19,363,540
JBrowse link
G RRAGC Ras related GTP binding C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:38,110,578...38,132,179
Ensembl chr 1:39,456,768...39,478,244
JBrowse link
G RTN4 reticulon 4 involved_in ISO (MGI:6274965|PMID:25917084) UniProt PMID:25917084 MGI:6274965 NCBI chr2A:55,129,272...55,207,031 JBrowse link
G SH3BP4 SH3 domain binding protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:122,179,431...122,284,430
Ensembl chr2B:241,089,624...241,149,524
JBrowse link
G SZT2 SZT2 subunit of KICSTOR complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:42,691,292...42,754,046
Ensembl chr 1:44,068,998...44,129,456
JBrowse link
N-glycan processing to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNPTAB N-acetylglucosamine-1-phosphate transferase subunits alpha and beta involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr12:99,328,026...99,418,151
Ensembl chr12:102,729,615...102,816,560
JBrowse link
negative regulation of protein localization to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:11,167,353...11,331,339
Ensembl chr2A:11,318,370...11,478,986
JBrowse link
neurotransmitter receptor transport, postsynaptic endosome to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3D1 adaptor related protein complex 3 subunit delta 1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr19:1,110,419...1,161,826
Ensembl chr19:2,085,540...2,137,593
JBrowse link
G CACNG2 calcium voltage-gated channel auxiliary subunit gamma 2 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr22:17,475,693...17,618,299
Ensembl chr22:35,317,121...35,454,850
JBrowse link
G CACNG3 calcium voltage-gated channel auxiliary subunit gamma 3 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr16:24,501,881...24,608,921 JBrowse link
G CACNG4 calcium voltage-gated channel auxiliary subunit gamma 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:60,900,645...60,969,659 JBrowse link
G CACNG5 calcium voltage-gated channel auxiliary subunit gamma 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:60,771,501...60,831,190
Ensembl chr17:65,979,469...66,031,723
JBrowse link
G CACNG7 calcium voltage-gated channel auxiliary subunit gamma 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:50,849,785...50,880,904
Ensembl chr19:59,701,451...59,724,809
JBrowse link
positive regulation of protein localization to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPR137B G protein-coupled receptor 137B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:211,709,507...211,775,846
Ensembl chr 1:216,696,105...216,778,370
JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:67,177,580...67,183,631
Ensembl chr11:70,390,141...70,407,246
JBrowse link
G MEAK7 MTOR associated protein, eak-7 homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:65,141,319...65,167,898
Ensembl chr16:84,482,997...84,509,530
JBrowse link
protein targeting to lysosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP3B1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2679144|PMID:14557411) MGI
Ensembl
PMID:14557411 GO_REF:0000107 MGI:2679144 NCBI chr 5:37,015,518...37,305,769
Ensembl chr 5:37,503,162...37,840,205
JBrowse link
G AP4M1 adaptor related protein complex 4 subunit mu 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:92,137,085...92,142,756
Ensembl chr 7:105,570,205...105,575,971
JBrowse link
G GCC2 GRIP and coiled-coil domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:94,659,117...94,721,491
Ensembl chr2A:109,682,552...109,734,682
JBrowse link
G GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:69,185,045...69,208,766
Ensembl chr17:74,737,164...74,762,039
JBrowse link
G HGS hepatocyte growth factor-regulated tyrosine kinase substrate involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:76,143,212...76,161,469
Ensembl chr17:81,844,379...81,862,335
JBrowse link
G LAPTM5 lysosomal protein transmembrane 5 involved_in ISO (MGI:3803048|PMID:18619870) ARUK-UCL PMID:18619870 MGI:3803048 NCBI chr 1:30,005,941...30,031,366
Ensembl chr 1:31,032,963...31,058,385
JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor ISO chorionic gonadotropin after receptor internalization RGD PMID:10847593 RGD:2292601 NCBI chr2A:48,808,822...48,879,021
Ensembl chr2A:49,729,002...49,798,780
JBrowse link
G M6PR mannose-6-phosphate receptor, cation dependent involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chr12:9,025,394...9,034,768
Ensembl chr12:9,256,706...9,266,428
JBrowse link
G NCOA4 nuclear receptor coactivator 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:25327288) MGI
Ensembl
PMID:25327288 GO_REF:0000107 NCBI chr10:43,159,014...43,184,558
Ensembl chr10:46,420,952...46,443,223
JBrowse link
G NDP norrin cystine knot growth factor NDP acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5921629|PMID:28675177) MGI
Ensembl
PMID:28675177 GO_REF:0000107 MGI:5921629 NCBI chr  X:36,399,868...36,424,953
Ensembl chr  X:44,224,161...44,249,067
JBrowse link
G NEDD4 NEDD4 E3 ubiquitin protein ligase involved_in ISO (PMID:17116753) ARUK-UCL PMID:17116753 NCBI chr15:34,798,880...34,963,823
Ensembl chr15:53,118,411...53,283,076
JBrowse link
G RAB7A RAB7A, member RAS oncogene family involved_in ISO (PMID:22115783) BHF-UCL PMID:22115783 NCBI chr 3:125,784,604...125,873,051 JBrowse link
G SCARB2 scavenger receptor class B member 2 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 4:47,992,589...48,047,528
Ensembl chr 4:53,830,488...53,886,059
JBrowse link
G SNX16 sorting nexin 16 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 8:78,324,407...78,367,143
Ensembl chr 8:79,944,729...79,987,430
JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr11:116,297,014...116,477,399
Ensembl chr11:120,222,491...120,402,432
JBrowse link
G SORT1 sortilin 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4368056|PMID:19732768) MGI
Ensembl
PMID:19732768 GO_REF:0000107 MGI:4368056 NCBI chr 1:111,687,119...111,775,339 JBrowse link
G VPS4A vacuolar protein sorting 4 homolog A involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:49,685,827...49,699,542
Ensembl chr16:69,074,091...69,085,714
JBrowse link
G VPS53 VPS53 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:400,048...576,119
Ensembl chr17:414,782...604,705
JBrowse link
G VPS54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:63,959,930...64,087,102
Ensembl chr2A:65,086,374...65,176,634
JBrowse link
G ZFYVE16 zinc finger FYVE-type containing 16 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 5:34,837,410...34,910,416
Ensembl chr 5:35,111,723...35,183,028
JBrowse link
protein targeting to lysosome involved in chaperone-mediated autophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523
JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chr11:117,890,545...117,895,262
Ensembl chr11:121,809,800...121,815,773
JBrowse link
G LAMP2 lysosomal associated membrane protein 2 acts_upstream_of_or_within
involved_in
ISO
IEA
PMID:18644871 MGI
TreeGrafter
Ensembl
PMID:18644871 GO_REF:0000107 GO_REF:0000118 RGD:10412301 NCBI chr  X:109,700,185...109,743,579
Ensembl chr  X:119,886,982...119,929,896
JBrowse link
G LOC100968349 heat shock cognate 71 kDa protein-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:84,809,840...84,812,136 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16309
    localization 5233
      macromolecule localization 2950
        cellular macromolecule localization 2529
          protein localization 2517
            protein localization to organelle 1027
              protein localization to vacuole 83
                protein localization to lysosome 50
                  negative regulation of protein localization to lysosome 2
                  neurotransmitter receptor transport, postsynaptic endosome to lysosome 6
                  positive regulation of protein localization to lysosome 3
                  protein targeting to lysosome + 25
                  regulation of protein localization to lysosome + 5
paths to the root