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ONTOLOGY REPORT - ANNOTATIONS


Term:testosterone biosynthetic process
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Accession:GO:0061370 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5.



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testosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 involved_in ISO (PMID:16983398) RGD PMID:16983398 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 IEP RGD PMID:19883722 RGD:4145609 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2154536 (MGI:1261712|PMID:9618522)
Ensembl
RGD
PMID:9618522 GO_REF:0000107 MGI:1261712 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 involved_in IDA
ISO
(MGI:1267145|PMID:9658408) RGD PMID:9658408 PMID:8612487 MGI:1267145, RGD:728619 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 involved_in IEA GO_REF:0000002
GO_REF:0000041
InterPro
UniProt
GO_REF:0000002 GO_REF:0000041 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 IEP RGD PMID:16467141 RGD:4889544 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 involved_in ISO
ISS
(PMID:10898110)
GO_REF:0000024
RGD
UniProt
PMID:10898110 GO_REF:0000024 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112
JBrowse link
G Star steroidogenic acute regulatory protein IEP RGD PMID:19883722 RGD:4145609 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
negative regulation of testosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkkl1 dickkopf like acrosomal protein 1 involved_in ISO (MGI:3839065|PMID:18818293) RGD PMID:18818293 MGI:3839065 NCBI chr 1:95,694,010...95,699,259
Ensembl chr 1:95,694,010...95,699,259
JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO
IEA
(PMID:12949260)
(MGI:2675528|PMID:12949260)
GO_REF:0000107
RGD
Ensembl
PMID:12949260 GO_REF:0000107 MGI:2675528 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
JBrowse link
regulation of testosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 involved_in ISO (PMID:19336506) RGD PMID:19336506 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A acts_upstream_of_or_within ISO (MGI:4352991|PMID:19398553) RGD PMID:19398553 MGI:4352991 NCBI chr19:671,719...678,839
Ensembl chr19:671,719...678,837
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 IMP RGD PMID:22429315 RGD:7775068 NCBI chr 1:228,409,883...229,638,794
Ensembl chr 1:228,408,947...229,639,080
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    metabolic process 11458
      biosynthetic process 5812
        olefinic compound biosynthetic process 32
          testosterone biosynthetic process 12
            negative regulation of testosterone biosynthetic process 2
            regulation of testosterone biosynthetic process + 5
Path 2
Term Annotations click to browse term
  biological_process 18734
    metabolic process 11458
      primary metabolic process 10260
        lipid metabolic process 1423
          steroid metabolic process 345
            steroid biosynthetic process 172
              testosterone biosynthetic process 12
                negative regulation of testosterone biosynthetic process 2
                regulation of testosterone biosynthetic process + 5
paths to the root