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ONTOLOGY REPORT - ANNOTATIONS

Term:cardiac conduction
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Accession:GO:0061337 term browser browse the term
Definition:Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.
Synonyms:xref: Reactome:R-HSA-5576891 "Cardiac conduction"


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cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC9 ATP binding cassette subfamily C member 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:64,357,176...64,500,358
Ensembl chr12:66,960,888...67,102,496 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826 		JBrowse link
G GJA1 gap junction protein alpha 1 acts_upstream_of_or_within ISO (PMID:10969038), (PMID:9109444) MGI PMID:9109444 PMID:10969038 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:23542581) MGI PMID:23542581 NCBI chr11:2,469,750...2,874,467 JBrowse link
G MEF2A myocyte enhancer factor 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:78,246,439...78,396,720
Ensembl chr15:97,428,744...97,579,092 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 acts_upstream_of_or_within ISO (PMID:20062061) MGI PMID:20062061 NCBI chr 3:38,593,765...38,691,172
Ensembl chr 3:38,876,068...38,972,247 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:31,974,499...31,984,488
Ensembl chr19:40,711,281...40,724,052 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 acts_upstream_of_or_within_positive_effect IEA Ensembl GO_REF:0000107 NCBI chr11:112,996,609...113,010,412
Ensembl chr11:116,928,676...116,942,500 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:118,460,860...118,486,563
Ensembl chr11:122,377,643...122,403,063 		JBrowse link
G SLC4A3 solute carrier family 4 member 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2B:106,884,750...106,899,143
Ensembl chr2B:225,475,148...225,489,189 		JBrowse link
G SPTBN4 spectrin beta, non-erythrocytic 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:37,515,420...37,621,473
Ensembl chr19:46,042,387...46,127,429 		JBrowse link
G TMEM65 transmembrane protein 65 involved_in ISO (PMID:36257954) UniProt PMID:36257954 NCBI chr 8:120,993,261...121,059,743 JBrowse link
G ZMPSTE24 zinc metallopeptidase STE24 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:39,545,264...39,589,721
Ensembl chr 1:40,869,076...40,912,747 		JBrowse link
atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in ISO (PMID:19343045), (PMID:23264583)
(PMID:18281375)		 BHF-UCL PMID:18281375 PMID:19343045 PMID:23264583 NCBI chr12:5,165,057...5,168,307 JBrowse link
G KCNE5 potassium voltage-gated channel subfamily E regulatory subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:98,731,109...98,732,575
Ensembl chr  X:109,202,320...109,202,748 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:12522251) BHF-UCL PMID:12522251 NCBI chr11:2,469,750...2,874,467 JBrowse link
G NUP155 nucleoporin 155 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:73,000,597...73,080,417
Ensembl chr 5:78,285,001...78,360,601 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:118,460,860...118,486,563
Ensembl chr11:122,377,643...122,403,063 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
atrial cardiac muscle cell to AV node cell communication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in ISO (PMID:12571597) BHF-UCL PMID:12571597 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905 		JBrowse link
atrial cardiac muscle cell to AV node cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,593,765...38,691,172
Ensembl chr 3:38,876,068...38,972,247 		JBrowse link
G SCN4B sodium voltage-gated channel beta subunit 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:112,967,190...112,986,727
Ensembl chr11:116,899,268...116,918,892 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
AV node cell to bundle of His cell communication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXADR CXADR Ig-like cell adhesion molecule involved_in ISO (PMID:18636119) UniProt PMID:18636119 NCBI chr21:4,246,779...4,367,369
Ensembl chr21:17,636,952...17,693,324 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
AV node cell to bundle of His cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G GJC1 gap junction protein gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:12,492,285...12,524,615
Ensembl chr17:12,689,251...12,690,441 		JBrowse link
G GJD3 gap junction protein delta 3 NOT|involved_in ISO (PMID:19168070)
(PMID:16571663), (PMID:22982984)		 BHF-UCL PMID:16571663 PMID:19168070 PMID:22982984 NCBI chr17:16,925,395...16,929,683 JBrowse link
AV node cell-bundle of His cell adhesion involved in cell communication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXADR CXADR Ig-like cell adhesion molecule involved_in ISO (PMID:18636119) BHF-UCL PMID:18636119 NCBI chr21:4,246,779...4,367,369
Ensembl chr21:17,636,952...17,693,324 		JBrowse link
bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,593,765...38,691,172
Ensembl chr 3:38,876,068...38,972,247 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
bundle of His cell to Purkinje myocyte communication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100990811 fucose-1-phosphate guanylyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:73,464,364...73,772,977
Ensembl chr 1:75,403,555...75,747,240 		JBrowse link
bundle of His cell to Purkinje myocyte communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G TBX5 T-box transcription factor 5 acts_upstream_of_positive_effect IEA Ensembl GO_REF:0000107 NCBI chr12:111,954,222...112,009,261
Ensembl chr12:115,333,609...115,389,739 		JBrowse link
bundle of His cell-Purkinje myocyte adhesion involved in cell communication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNNA3 catenin alpha 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:62,388,454...64,177,116
Ensembl chr10:64,712,576...66,442,238 		JBrowse link
G DSC2 desmocollin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:24,296,505...24,332,997
Ensembl chr18:27,894,603...27,930,843 		JBrowse link
G DSG2 desmoglein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:24,716,181...24,766,837
Ensembl chr18:28,313,223...28,363,786 		JBrowse link
G DSP desmoplakin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:7,381,046...7,426,408
Ensembl chr 6:7,664,211...7,709,391 		JBrowse link
G JUP junction plakoglobin involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,527,115...15,559,251
Ensembl chr17:15,747,163...15,777,479 		JBrowse link
G PKP2 plakophilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:53,322,227...53,428,747
Ensembl chr12:55,925,174...56,030,998 		JBrowse link
cell communication by electrical coupling involved in cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 involved_in
acts_upstream_of_or_within		 IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 involved_in ISO PMID:21779914 BHF-UCL PMID:21779914 RGD:8554732 NCBI chr2A:40,169,339...40,586,546
Ensembl chr2A:40,939,900...41,363,038 		JBrowse link
cell communication involved in cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C acts_upstream_of_or_within ISO (PMID:32109384) MGI PMID:32109384 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G GJD3 gap junction protein delta 3 NOT|involved_in ISO (PMID:19168070) BHF-UCL PMID:19168070 NCBI chr17:16,925,395...16,929,683 JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:18,459,528...18,862,495
Ensembl chr10:18,795,832...19,195,226 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:18,459,528...18,862,495
Ensembl chr10:18,795,832...19,195,226 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:73,917,439...74,410,627
Ensembl chr 7:87,579,004...88,068,482 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:31,974,499...31,984,488
Ensembl chr19:40,711,281...40,724,052 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12700358) Ensembl
MGI		 PMID:12700358 GO_REF:0000107 NCBI chr 3:53,432,189...53,751,347
Ensembl chr 3:54,495,952...54,970,444 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,231,906...52,285,220
Ensembl chr15:70,997,020...71,042,285 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
membrane repolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in ISO (PMID:19343045), (PMID:23264583) BHF-UCL PMID:19343045 PMID:23264583 NCBI chr12:5,165,057...5,168,307 JBrowse link
G KCNJ5 potassium inwardly rectifying channel subfamily J member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:123,705,361...123,735,370
Ensembl chr11:127,606,208...127,634,213 		JBrowse link
G KCNN2 potassium calcium-activated channel subfamily N member 2 involved_in ISO (PMID:19139040) BHF-UCL PMID:19139040 NCBI chr 5:109,722,916...109,862,747
Ensembl chr 5:115,522,443...115,661,079 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:12522251), (PMID:25786344) BHF-UCL PMID:12522251 PMID:25786344 NCBI chr11:2,469,750...2,874,467 JBrowse link
membrane repolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in ISO (PMID:23264583) BHF-UCL PMID:23264583 NCBI chr12:5,165,057...5,168,307 JBrowse link
membrane repolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in ISO (PMID:19343045) BHF-UCL PMID:19343045 NCBI chr12:5,165,057...5,168,307 JBrowse link
negative regulation of cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJD3 gap junction protein delta 3 involved_in ISO (PMID:16571663) BHF-UCL PMID:16571663 NCBI chr17:16,925,395...16,929,683 JBrowse link
negative regulation of cell communication by electrical coupling involved in cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJD3 gap junction protein delta 3 NOT|involved_in ISO (PMID:19168070)
(PMID:16571663)		 BHF-UCL PMID:16571663 PMID:19168070 NCBI chr17:16,925,395...16,929,683 JBrowse link
positive regulation of atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPM4 transient receptor potential cation channel subfamily M member 4 ISO RGD PMID:23954346 RGD:10003031 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464 		JBrowse link
positive regulation of cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TBX5 T-box transcription factor 5 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr12:111,954,222...112,009,261
Ensembl chr12:115,333,609...115,389,739 		JBrowse link
positive regulation of cell communication by electrical coupling involved in cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRDN triadin involved_in ISO (PMID:15731460) BHF-UCL PMID:15731460 NCBI chr 6:121,010,234...121,424,644
Ensembl chr 6:125,134,433...125,546,537 		JBrowse link
Purkinje myocyte to ventricular cardiac muscle cell signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR2 ryanodine receptor 2 involved_in ISO (PMID:17872467) BHF-UCL PMID:17872467 NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509 		JBrowse link
regulation of atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905 		JBrowse link
G GJA5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G RYR2 ryanodine receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509 		JBrowse link
regulation of AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in ISO (PMID:12571597) BHF-UCL PMID:12571597 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905 		JBrowse link
G CXADR CXADR Ig-like cell adhesion molecule involved_in ISO (PMID:18636119) BHF-UCL PMID:18636119 NCBI chr21:4,246,779...4,367,369
Ensembl chr21:17,636,952...17,693,324 		JBrowse link
G GJA5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G RYR2 ryanodine receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509 		JBrowse link
regulation of bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G RANGRF RAN guanine nucleotide release factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:43,369,556...43,371,025
Ensembl chr17:48,101,744...48,103,394 		JBrowse link
regulation of cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE2 angiotensin converting enzyme 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:8,189,267...8,229,415
Ensembl chr  X:15,470,896...15,510,891 		JBrowse link
G AGT angiotensinogen involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:206,252,141...206,263,830
Ensembl chr 1:211,279,015...211,291,044 		JBrowse link
G EHD3 EH domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:31,245,908...31,280,485
Ensembl chr2A:31,317,432...31,353,312 		JBrowse link
G LOC100990811 fucose-1-phosphate guanylyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:73,464,364...73,772,977
Ensembl chr 1:75,403,555...75,747,240 		JBrowse link
G NKX2-5 NK2 homeobox 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:168,584,197...168,589,406
Ensembl chr 5:175,492,288...175,495,514 		JBrowse link
G TMEM65 transmembrane protein 65 involved_in ISO (PMID:26403541) UniProt PMID:26403541 NCBI chr 8:120,993,261...121,059,743 JBrowse link
regulation of cell communication by electrical coupling involved in cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G HRC histidine rich calcium binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,162,231...46,166,606
Ensembl chr19:55,089,384...55,093,463 		JBrowse link
G IRX3 iroquois homeobox 3 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr16:34,514,107...34,517,576
Ensembl chr16:53,622,409...53,624,653 		JBrowse link
G PDE4D phosphodiesterase 4D involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:53,510,287...55,039,181
Ensembl chr 5:55,749,214...56,670,111 		JBrowse link
G SRI sorcin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:80,199,719...80,214,733
Ensembl chr 7:93,850,496...93,864,029 		JBrowse link
regulation of heart rate by cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:57,556,294...57,577,294
Ensembl chr17:62,702,341...62,733,853 		JBrowse link
G AKAP9 A-kinase anchoring protein 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:83,942,590...84,108,648
Ensembl chr 7:97,540,356...97,705,608 		JBrowse link
G ANK2 ankyrin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905 		JBrowse link
G BIN1 bridging integrator 1 involved_in ISO (PMID:24836577) ARUK-UCL PMID:24836577 NCBI chr2B:33,168,767...33,228,075
Ensembl chr2B:127,716,550...127,775,378 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12700358) Ensembl
MGI		 PMID:12700358 GO_REF:0000107 NCBI chr 3:53,432,189...53,751,347
Ensembl chr 3:54,495,952...54,970,444 		JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:73,917,439...74,410,627
Ensembl chr 7:87,579,004...88,068,482 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:18,459,528...18,862,495
Ensembl chr10:18,795,832...19,195,226 		JBrowse link
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CTNNA3 catenin alpha 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:62,388,454...64,177,116
Ensembl chr10:64,712,576...66,442,238 		JBrowse link
G DSC2 desmocollin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:24,296,505...24,332,997
Ensembl chr18:27,894,603...27,930,843 		JBrowse link
G DSG2 desmoglein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:24,716,181...24,766,837
Ensembl chr18:28,313,223...28,363,786 		JBrowse link
G DSP desmoplakin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:7,381,046...7,426,408
Ensembl chr 6:7,664,211...7,709,391 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,231,906...52,285,220
Ensembl chr15:70,997,020...71,042,285 		JBrowse link
G ISL1 ISL LIM homeobox 1 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 5:62,635,095...62,650,141
Ensembl chr 5:64,252,715...64,264,674 		JBrowse link
G JUP junction plakoglobin involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,527,115...15,559,251
Ensembl chr17:15,747,163...15,777,479 		JBrowse link
G KCNA5 potassium voltage-gated channel subfamily A member 5 involved_in ISO (PMID:19343045), (PMID:23264583) BHF-UCL PMID:19343045 PMID:23264583 NCBI chr12:5,165,057...5,168,307 JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:114,433,203...114,651,894
Ensembl chr 1:125,696,907...125,909,814 		JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr21:20,818,395...20,884,053
Ensembl chr21:34,190,043...34,190,441 		JBrowse link
G KCNE2 potassium voltage-gated channel subfamily E regulatory subunit 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118
G KCNE3 potassium voltage-gated channel subfamily E regulatory subunit 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:69,527,663...69,540,236
Ensembl chr11:72,835,048...72,835,359 		JBrowse link
G KCNE4 potassium voltage-gated channel subfamily E regulatory subunit 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:110,291,194...110,294,996
Ensembl chr2B:228,869,393...228,873,101 		JBrowse link
G KCNE5 potassium voltage-gated channel subfamily E regulatory subunit 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:98,731,109...98,732,575
Ensembl chr  X:109,202,320...109,202,748 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:7889573)
(PMID:10843886)		 MGI
TreeGrafter		 PMID:7889573 PMID:10843886 GO_REF:0000118 NCBI chr 7:142,528,979...142,562,074 JBrowse link
G KCNH6 potassium voltage-gated channel subfamily H member 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:57,603,039...57,626,964
Ensembl chr17:62,749,216...62,772,544 		JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:64,097,908...64,112,914
Ensembl chr17:69,487,846...69,489,129 		JBrowse link
G KCNJ5 potassium inwardly rectifying channel subfamily J member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:123,705,361...123,735,370
Ensembl chr11:127,606,208...127,634,213 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 involved_in ISO (PMID:8528244) BHF-UCL PMID:8528244 NCBI chr11:2,469,750...2,874,467 JBrowse link
G LOC106634235 uncharacterized LOC106634235 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr21:20,548,631...20,739,999
Ensembl chr21:34,107,443...34,107,814
Ensembl chr21:34,107,443...34,107,814 		JBrowse link
G PKP2 plakophilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:53,322,227...53,428,747
Ensembl chr12:55,925,174...56,030,998 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:31,974,499...31,984,488
Ensembl chr19:40,711,281...40,724,052 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:112,996,609...113,010,412
Ensembl chr11:116,928,676...116,942,500 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:118,460,860...118,486,563
Ensembl chr11:122,377,643...122,403,063 		JBrowse link
G SCN4B sodium voltage-gated channel beta subunit 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:112,967,190...112,986,727
Ensembl chr11:116,899,268...116,918,892 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11972032), (PMID:15809371), (PMID:15932895), (PMID:16172272) Ensembl
MGI		 PMID:11972032 PMID:15809371 PMID:15932895 PMID:16172272 GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464 		JBrowse link
regulation of Purkinje myocyte action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA5 gap junction protein alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
regulation of SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905 		JBrowse link
G RYR2 ryanodine receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509 		JBrowse link
G TBX18 T-box transcription factor 18 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 6:82,621,987...82,654,137
Ensembl chr 6:85,862,810...85,938,799 		JBrowse link
regulation of the force of heart contraction by cardiac conduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLN phospholamban acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668 		JBrowse link
G SLC9A1 solute carrier family 9 member A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:26,359,818...26,418,910
Ensembl chr 1:27,414,937...27,475,089 		JBrowse link
SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in ISO (PMID:18832177) BHF-UCL PMID:18832177 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,231,906...52,285,220
Ensembl chr15:70,997,020...71,042,285 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:118,460,860...118,486,563
Ensembl chr11:122,377,643...122,403,063 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
SA node cell to atrial cardiac muscle cell communication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:105,315,776...105,882,506
Ensembl chr 4:115,967,106...116,443,905 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    multicellular organismal process 7357
      system process 2241
        regulation of system process 674
          regulation of blood circulation 284
            regulation of heart contraction 211
              cardiac conduction 68
                cell communication involved in cardiac conduction + 40
                negative regulation of cardiac conduction 1
                positive regulation of cardiac conduction 1
                regulation of cardiac conduction + 12
                regulation of heart rate by cardiac conduction 38
                regulation of the force of heart contraction by cardiac conduction 2
Path 2
Term Annotations click to browse term
  biological_process 19315
    multicellular organismal process 7357
      system process 2241
        circulatory system process 590
          blood circulation 563
            heart contraction 249
              regulation of heart contraction 211
                cardiac conduction 68
                  cell communication involved in cardiac conduction + 40
                  negative regulation of cardiac conduction 1
                  positive regulation of cardiac conduction 1
                  regulation of cardiac conduction + 12
                  regulation of heart rate by cardiac conduction 38
                  regulation of the force of heart contraction by cardiac conduction 2
paths to the root