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ONTOLOGY REPORT - ANNOTATIONS


Term:cell proliferation involved in heart morphogenesis
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Accession:GO:0061323 term browser browse the term
Definition:The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart.



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canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNNB1 catenin beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G LRP6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (MGI:4413394|PMID:19705442) MGI PMID:19705442 MGI:4413394 NCBI chr 5:60,149,041...60,318,719
Ensembl chr 5:60,149,028...60,314,689
JBrowse link
cell proliferation involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFBR2 transforming growth factor beta receptor 2 NOT|involved_in ISO (MGI:4821522|PMID:20652948) BHF-UCL PMID:20652948 MGI:4821522 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,491...16,878,165
JBrowse link
cell proliferation involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAND2 heart and neural crest derivatives expressed 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4453274|PMID:20144608) Ensembl
MGI
PMID:20144608 GO_REF:0000107 MGI:4453274 NCBI chr14:16,460,089...16,462,979
Ensembl chr14:16,460,119...16,462,735
JBrowse link
G PITX2 paired like homeodomain 2 acts_upstream_of_or_within
involved_in
ISO (MGI:3701739|PMID:16836994)
(MGI:2446944|PMID:12464179)
MGI
BHF-UCL
PMID:12464179 PMID:16836994 MGI:2446944 MGI:3701739 NCBI chr 8:111,697,364...111,723,295
Ensembl chr 8:111,698,664...111,723,298
JBrowse link
negative regulation of cell proliferation involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,134...183,792,417
JBrowse link
G TBX3 T-box transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:37,582,704...37,596,767
Ensembl chr14:37,582,822...37,596,767
JBrowse link
negative regulation of cell proliferation involved in heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR2 bone morphogenetic protein receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:105,971,577...106,132,496
Ensembl chr15:105,970,427...106,135,730
JBrowse link
G NOTCH1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOTCH1 notch receptor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4438134|PMID:19620969) Ensembl
MGI
PMID:19620969 GO_REF:0000107 MGI:4438134
positive regulation of cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase involved_in ISO (PMID:21474815) BHF-UCL PMID:21474815 NCBI chr 7:32,788,246...32,793,882
Ensembl chr 7:32,788,005...32,793,880
JBrowse link
positive regulation of cell proliferation involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP10 bone morphogenetic protein 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:73,519,904...73,530,448
Ensembl chr 3:73,519,934...73,529,977
JBrowse link
G NACA nascent polypeptide associated complex subunit alpha involved_in ISO (MGI:4867362|PMID:21071677) BHF-UCL PMID:21071677 MGI:4867362 NCBI chr 5:22,044,569...22,058,096 JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:19,933,035...20,166,746
Ensembl chr 8:19,922,779...20,166,755
JBrowse link
G SOX9 SRY-box transcription factor 9 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3709829|PMID:17350610) Ensembl
MGI
PMID:17350610 GO_REF:0000107 MGI:3709829 NCBI chr12:8,642,154...8,647,315
Ensembl chr12:8,642,158...8,647,315
JBrowse link
positive regulation of cell proliferation involved in heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,514,791...100,628,029
JBrowse link
positive regulation of cell proliferation involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,134...183,792,417
JBrowse link
positive regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EYA1 EYA transcriptional coactivator and phosphatase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5002778|PMID:21364285) Ensembl
MGI
PMID:21364285 GO_REF:0000107 MGI:5002778 NCBI chr 4:63,970,939...64,328,107
Ensembl chr 4:63,970,511...64,328,105
JBrowse link
G GNG5 G protein subunit gamma 5 acts_upstream_of_or_within ISO (MGI:5604689|PMID:24599258) MGI PMID:24599258 MGI:5604689 NCBI chr 6:129,247,324...129,254,973 JBrowse link
G SIX1 SIX homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5002778|PMID:21364285) Ensembl
MGI
PMID:21364285 GO_REF:0000107 MGI:5002778 NCBI chr 1:189,620,430...189,624,652
Ensembl chr 1:189,619,853...189,628,187
JBrowse link
G TBX1 T-box transcription factor 1 acts_upstream_of_or_within ISO (MGI:4943633|PMID:19745164) MGI PMID:19745164 MGI:4943633 NCBI chr14:51,289,376...51,297,110
Ensembl chr14:51,289,143...51,296,725
JBrowse link
G TBX5 T-box transcription factor 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5437816|PMID:22898775) Ensembl
MGI
PMID:22898775 GO_REF:0000107 MGI:5437816 NCBI chr14:37,772,205...37,826,015
Ensembl chr14:37,773,605...37,824,400
JBrowse link
regulation of cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOTCH1 notch receptor 1 ISO RGD PMID:18824567 RGD:2325311
regulation of cell proliferation involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENG endoglin NOT|involved_in ISO (MGI:3721185|PMID:17628518) BHF-UCL PMID:17628518 MGI:3721185 NCBI chr 1:268,309,379...268,343,861
Ensembl chr 1:268,306,120...268,343,827
JBrowse link
regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNNB1 catenin beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4438134|PMID:19620969) Ensembl
MGI
PMID:19620969 GO_REF:0000107 MGI:4438134 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:16,460,089...16,462,979
Ensembl chr14:16,460,119...16,462,735
JBrowse link
G HES1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4354447|PMID:19609448) Ensembl
MGI
PMID:19609448 GO_REF:0000107 MGI:4354447 NCBI chr13:131,135,970...131,137,865
Ensembl chr13:131,135,724...131,138,236
JBrowse link
G ISL1 ISL LIM homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4438134|PMID:19620969) Ensembl
MGI
PMID:19620969 GO_REF:0000107 MGI:4438134 NCBI chr16:30,962,994...30,974,201
Ensembl chr16:30,963,000...30,973,907
JBrowse link
smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MKS1 MKS transition zone complex subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5811184|PMID:27340223) Ensembl
MGI
PMID:27340223 GO_REF:0000107 MGI:5811184 NCBI chr12:34,499,139...34,512,191
Ensembl chr12:34,499,141...34,512,187
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16581
    cellular process 15867
      cell population proliferation 2062
        cell proliferation involved in heart morphogenesis 24
          cardioblast proliferation + 12
          cell proliferation involved in atrial ventricular junction remodeling 0
          cell proliferation involved in endocardial cushion morphogenesis 1
          cell proliferation involved in heart valve morphogenesis + 3
          cell proliferation involved in outflow tract morphogenesis + 5
          fibroblast proliferation involved in heart morphogenesis 0
          negative regulation of cell proliferation involved in heart morphogenesis + 4
          positive regulation of cell proliferation involved in heart morphogenesis + 7
          regulation of cell proliferation involved in heart morphogenesis + 22
Path 2
Term Annotations click to browse term
  biological_process 16581
    developmental process 6319
      anatomical structure development 5836
        multicellular organism development 5309
          system development 5000
            circulatory system development 1203
              heart development 679
                heart morphogenesis 282
                  cell proliferation involved in heart morphogenesis 24
                    cardioblast proliferation + 12
                    cell proliferation involved in atrial ventricular junction remodeling 0
                    cell proliferation involved in endocardial cushion morphogenesis 1
                    cell proliferation involved in heart valve morphogenesis + 3
                    cell proliferation involved in outflow tract morphogenesis + 5
                    fibroblast proliferation involved in heart morphogenesis 0
                    negative regulation of cell proliferation involved in heart morphogenesis + 4
                    positive regulation of cell proliferation involved in heart morphogenesis + 7
                    regulation of cell proliferation involved in heart morphogenesis + 22
paths to the root