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ONTOLOGY REPORT - ANNOTATIONS

Term:cell proliferation involved in heart morphogenesis
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Accession:GO:0061323 term browser browse the term
Definition:The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart.


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cell proliferation involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOX9 SRY-box transcription factor 9 acts_upstream_of ISO (PMID:17350610) MGI PMID:17350610 NCBI chr17:66,028,737...66,034,122 JBrowse link
cell proliferation involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFBR2 transforming growth factor beta receptor 2 NOT|involved_in ISO (MGI:4821522|PMID:20652948) BHF-UCL PMID:20652948 MGI:4821522 NCBI chr 3:30,536,187...30,623,653
Ensembl chr 3:30,854,460...30,938,856 		JBrowse link
cell proliferation involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAND2 heart and neural crest derivatives expressed 2 acts_upstream_of_or_within ISO (PMID:20144608) MGI PMID:20144608 NCBI chr 4:165,755,000...165,758,735 JBrowse link
G PITX2 paired like homeodomain 2 acts_upstream_of_or_within ISO (PMID:16836994) MGI PMID:16836994 NCBI chr 4:103,112,624...103,137,356 JBrowse link
negative regulation of cell proliferation involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TBX3 T-box transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:112,240,050...112,254,299
Ensembl chr12:115,620,002...115,631,316 		JBrowse link
negative regulation of cell proliferation involved in heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR2 bone morphogenetic protein receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:89,631,622...89,823,438
Ensembl chr2B:207,780,741...207,961,072 		JBrowse link
G NOTCH1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:107,568,670...107,621,032
Ensembl chr 9:136,544,639...136,598,740 		JBrowse link
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOTCH1 notch receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19620969) Ensembl
MGI		 PMID:19620969 GO_REF:0000107 NCBI chr 9:107,568,670...107,621,032
Ensembl chr 9:136,544,639...136,598,740 		JBrowse link
positive regulation of cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase involved_in ISO (PMID:21474815) BHF-UCL PMID:21474815 NCBI chr 6:36,730,669...36,735,954 JBrowse link
positive regulation of cell proliferation involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP10 bone morphogenetic protein 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:68,901,944...68,912,559
Ensembl chr2A:70,023,655...70,034,420 		JBrowse link
G LOC100995452 nascent polypeptide associated complex subunit alpha involved_in ISO (MGI:4867362|PMID:21071677) BHF-UCL PMID:21071677 MGI:4867362 NCBI chr12:32,180,823...32,195,645
Ensembl chr12:32,434,366...32,447,510 		JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:3701380|PMID:17336907) BHF-UCL PMID:17336907 MGI:3701380 NCBI chr 4:20,719,548...20,835,439
Ensembl chr 4:25,995,263...26,107,683 		JBrowse link
G SOX9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO (PMID:17350610) MGI PMID:17350610 NCBI chr17:66,028,737...66,034,122 JBrowse link
positive regulation of cell proliferation involved in heart valve morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:44,402,112...44,456,779
Ensembl chr18:47,764,568...47,797,359 		JBrowse link
positive regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EYA1 EYA transcriptional coactivator and phosphatase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21364285) Ensembl
MGI		 PMID:21364285 GO_REF:0000107 NCBI chr 8:67,728,057...68,060,069
Ensembl chr 8:69,387,769...69,551,829 		JBrowse link
G GNG5 G protein subunit gamma 5 acts_upstream_of_or_within ISO (PMID:24599258) MGI PMID:24599258 NCBI chr 1:117,046,699...117,055,097 JBrowse link
G SIX1 SIX homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21364285) Ensembl
MGI		 PMID:21364285 GO_REF:0000107 NCBI chr14:41,250,512...41,256,567
Ensembl chr14:59,515,324...59,527,494 		JBrowse link
G TBX1 T-box transcription factor 1 acts_upstream_of_or_within ISO (PMID:19745164) MGI PMID:19745164 NCBI chr22:2,521,080...2,541,267 JBrowse link
G TBX5 T-box transcription factor 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22898775) Ensembl
MGI		 PMID:22898775 GO_REF:0000107 NCBI chr12:111,954,222...112,009,261
Ensembl chr12:115,333,609...115,389,739 		JBrowse link
regulation of cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOTCH1 notch receptor 1 ISO RGD PMID:18824567 RGD:2325311 NCBI chr 9:107,568,670...107,621,032
Ensembl chr 9:136,544,639...136,598,740 		JBrowse link
regulation of cell proliferation involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENG endoglin NOT|involved_in ISO (MGI:3721185|PMID:17628518) BHF-UCL PMID:17628518 MGI:3721185 NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641 		JBrowse link
regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNNB1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19620969) Ensembl
MGI		 PMID:19620969 GO_REF:0000107 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030 		JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 involved_in ISO (MGI:4413411|PMID:19008477) BHF-UCL PMID:19008477 MGI:4413411 NCBI chr 4:165,755,000...165,758,735 JBrowse link
G HES1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19609448) Ensembl
MGI		 PMID:19609448 GO_REF:0000107 NCBI chr 3:191,432,513...191,435,387
Ensembl chr 3:201,749,044...201,754,257 		JBrowse link
G ISL1 ISL LIM homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19620969) Ensembl
MGI		 PMID:19620969 GO_REF:0000107 NCBI chr 5:62,635,095...62,650,141
Ensembl chr 5:64,252,715...64,264,674 		JBrowse link
smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MKS1 MKS transition zone complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27340223) Ensembl
MGI		 PMID:27340223 GO_REF:0000107 NCBI chr17:52,281,443...52,295,919
Ensembl chr17:57,137,254...57,151,328 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16313
    cellular process 15397
      cell population proliferation 2123
        cell proliferation involved in heart morphogenesis 22
          cardioblast proliferation + 12
          cell proliferation involved in atrial ventricular junction remodeling 0
          cell proliferation involved in endocardial cushion morphogenesis 1
          cell proliferation involved in heart valve morphogenesis + 3
          cell proliferation involved in outflow tract morphogenesis + 2
          fibroblast proliferation involved in heart morphogenesis 0
          negative regulation of cell proliferation involved in heart morphogenesis + 3
          positive regulation of cell proliferation involved in heart morphogenesis + 6
          regulation of cell proliferation involved in heart morphogenesis + 20
Path 2
Term Annotations click to browse term
  biological_process 16313
    developmental process 6551
      anatomical structure development 6160
        multicellular organism development 4965
          system development 4315
            circulatory system development 1244
              heart development 708
                heart morphogenesis 280
                  cell proliferation involved in heart morphogenesis 22
                    cardioblast proliferation + 12
                    cell proliferation involved in atrial ventricular junction remodeling 0
                    cell proliferation involved in endocardial cushion morphogenesis 1
                    cell proliferation involved in heart valve morphogenesis + 3
                    cell proliferation involved in outflow tract morphogenesis + 2
                    fibroblast proliferation involved in heart morphogenesis 0
                    negative regulation of cell proliferation involved in heart morphogenesis + 3
                    positive regulation of cell proliferation involved in heart morphogenesis + 6
                    regulation of cell proliferation involved in heart morphogenesis + 20
paths to the root