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ONTOLOGY REPORT - ANNOTATIONS


Term:canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
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Accession:GO:0061317 term browser browse the term
Definition:The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Synonyms:exact_synonym: canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment;   canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment;   canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment



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canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
G Wnt8a Wnt family member 8A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr18:26,137,690...26,143,283
Ensembl chr18:26,137,690...26,143,283
JBrowse link
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within ISO MGI:3583755 (MGI:5432296|PMID:22711842) RGD PMID:22711842 MGI:5432296 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      cellular developmental process 4543
        cell fate commitment 282
          muscle cell fate commitment 15
            cardiac muscle cell fate commitment 10
              canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 4
                negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 1
                positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 1
                regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment + 2
Path 2
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure development 6306
        multicellular organism development 5727
          system development 5373
            circulatory system development 1244
              heart development 698
                cell surface receptor signaling pathway involved in heart development 29
                  Wnt signaling pathway involved in heart development 14
                    canonical Wnt signaling pathway involved in heart development 6
                      canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 4
                        negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 1
                        positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 1
                        regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment + 2
paths to the root