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ONTOLOGY REPORT - ANNOTATIONS


Term:canonical Wnt signaling pathway involved in heart development
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Accession:GO:0061316 term browser browse the term
Definition:The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Synonyms:exact_synonym: canonical Wnt receptor signaling pathway involved in heart development;   canonical Wnt receptor signalling pathway involved in heart development;   canonical Wnt-activated signaling pathway involved in heart development


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canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Wnt8a Wnt family member 8A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr18:27,331,236...27,336,829
Ensembl chr18:27,331,236...27,336,829
JBrowse link
canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2156191 (MGI:4413394|PMID:19705442) RGD PMID:19705442 MGI:4413394 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:2446944|PMID:12464179)
Ensembl
RGD
PMID:12464179 GO_REF:0000107 MGI:2446944 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2156191 (MGI:4413394|PMID:19705442) RGD PMID:19705442 MGI:4413394 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within ISO MGI:3583755 (MGI:5432296|PMID:22711842) RGD PMID:22711842 MGI:5432296 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    signaling 7520
      cell-cell signaling 1723
        cell surface receptor signaling pathway involved in cell-cell signaling 555
          Wnt signaling pathway 429
            Wnt signaling pathway involved in heart development 14
              canonical Wnt signaling pathway involved in heart development 6
                canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment + 4
                canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development 1
                canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation 0
                canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation 2
                canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation 0
                negative regulation of canonical Wnt signaling pathway involved in heart development + 1
                negative regulation of heart induction by canonical Wnt signaling pathway 1
                positive regulation of canonical Wnt signaling pathway involved in heart development + 1
                regulation of canonical Wnt signaling pathway involved in heart development + 2
Path 2
Term Annotations click to browse term
  biological_process 19634
    biological regulation 13612
      regulation of biological process 12859
        regulation of cellular process 12359
          signal transduction 6947
            cell surface receptor signaling pathway 2760
              cell surface receptor signaling pathway involved in cell-cell signaling 555
                Wnt signaling pathway 429
                  canonical Wnt signaling pathway 293
                    canonical Wnt signaling pathway involved in heart development 6
                      canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment + 4
                      canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development 1
                      canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation 0
                      canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation 2
                      canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation 0
                      negative regulation of canonical Wnt signaling pathway involved in heart development + 1
                      negative regulation of heart induction by canonical Wnt signaling pathway 1
                      positive regulation of canonical Wnt signaling pathway involved in heart development + 1
                      regulation of canonical Wnt signaling pathway involved in heart development + 2
paths to the root