Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:cell surface receptor signaling pathway involved in heart development
go back to main search page
Accession:GO:0061311 term browser browse the term
Definition:Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time.
Synonyms:exact_synonym: cell surface receptor linked signaling pathway involved in heart development;   cell surface receptor linked signalling pathway involved in heart development



show annotations for term's descendants           Sort by:
 
BMP signaling pathway involved in heart development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:3610266|PMID:16140292)
Ensembl
RGD
PMID:16140292 GO_REF:0000107 MGI:3610266 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:3640731|PMID:16730346)
Ensembl
RGD
PMID:16730346 GO_REF:0000107 MGI:3640731 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:3039210|PMID:15070745)
Ensembl
RGD
PMID:15070745 GO_REF:0000107 MGI:3039210 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (MGI:2175930|PMID:11854453) RGD PMID:11854453 MGI:2175930 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Chrd chordin involved_in ISO MGI:2157350 (MGI:3721005|PMID:17685487) RGD PMID:17685487 MGI:3721005 NCBI chr11:80,171,994...80,181,166
Ensembl chr11:80,171,994...80,180,673
JBrowse link
G Msx1 msh homeobox 1 acts_upstream_of_or_within ISO MGI:97169 (MGI:3810851|PMID:18667074) RGD PMID:18667074 MGI:3810851 NCBI chr14:72,961,170...72,964,970
Ensembl chr14:72,961,148...72,964,966
JBrowse link
G Msx2 msh homeobox 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97168 (MGI:3810851|PMID:18667074)
Ensembl
RGD
PMID:18667074 GO_REF:0000107 MGI:3810851 NCBI chr17:11,097,214...11,102,879
Ensembl chr17:11,097,103...11,102,879
JBrowse link
G Nog noggin involved_in IEA
ISO
GO_REF:0000107
(MGI:3783944|PMID:17218603)
Ensembl
RGD
PMID:17218603 GO_REF:0000107 MGI:3783944 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
JBrowse link
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
G Wnt8a Wnt family member 8A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr18:26,137,690...26,143,283
Ensembl chr18:26,137,690...26,143,283
JBrowse link
canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2156191 (MGI:4413394|PMID:19705442) RGD PMID:19705442 MGI:4413394 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:2446944|PMID:12464179)
Ensembl
RGD
PMID:12464179 GO_REF:0000107 MGI:2446944 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2156191 (MGI:4413394|PMID:19705442) RGD PMID:19705442 MGI:4413394 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:98958 (MGI:4830282|PMID:19056682) RGD PMID:19056682 MGI:4830282 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
negative regulation of Wnt signaling pathway involved in heart development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpk2 alpha-kinase 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:29888752)
UniProt
RGD
PMID:29888752 GO_REF:0000024 NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258
JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:18545679)
UniProt
RGD
PMID:18545679 GO_REF:0000024 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Sox17 SRY-box transcription factor 17 involved_in ISO (MGI:3703823|PMID:17360443) RGD PMID:17360443 MGI:3703823 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
Notch signaling involved in heart development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll4 delta like canonical Notch ligand 4 involved_in ISO (MGI:3056036|PMID:15466159) RGD PMID:15466159 MGI:3056036 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931
JBrowse link
G Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:9,837,629...9,871,141
Ensembl chr 4:9,837,629...9,871,140
JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:4359139|PMID:19509466)
(PMID:20437614)
Ensembl
RGD
PMID:19509466 PMID:20437614 GO_REF:0000107 MGI:4359139 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Notch1 notch receptor 1 involved_in ISO
ISS
(PMID:16025100), (PMID:17662764)
UniProtKB:Q02085 (MGI:3027664|PMID:14701881), (MGI:4837019|PMID:20890042), (MGI:4947514|PMID:20007915)
GO_REF:0000024
RGD
UniProt
PMID:14701881 PMID:16025100 PMID:17662764 PMID:20007915 PMID:20890042 GO_REF:0000024 MGI:3027664 MGI:4837019 MGI:4947514 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Snai1 snail family transcriptional repressor 1 involved_in ISO UniProtKB:Q01705 (MGI:4837019|PMID:20890042) RGD PMID:20890042 MGI:4837019 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 acts_upstream_of_or_within ISO (MGI:4438134|PMID:19620969) RGD PMID:19620969 MGI:4438134 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857617 (MGI:4830282|PMID:19056682)
Ensembl
RGD
PMID:19056682 GO_REF:0000107 MGI:4830282 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
planar cell polarity pathway involved in cardiac right atrium morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857617 (MGI:4830282|PMID:19056682)
Ensembl
RGD
PMID:19056682 GO_REF:0000107 MGI:4830282 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
planar cell polarity pathway involved in heart morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:5558098 (MGI:5544506|PMID:24302887) RGD PMID:24302887 MGI:5544506 NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378
JBrowse link
planar cell polarity pathway involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857617 (MGI:4830282|PMID:19056682)
Ensembl
RGD
PMID:19056682 GO_REF:0000107 MGI:4830282 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
planar cell polarity pathway involved in pericardium morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857617 (MGI:4830282|PMID:19056682)
Ensembl
RGD
PMID:19056682 GO_REF:0000107 MGI:4830282 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
planar cell polarity pathway involved in ventricular septum morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857617 (MGI:4830282|PMID:19056682)
Ensembl
RGD
PMID:19056682 GO_REF:0000107 MGI:4830282 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within ISO MGI:3583755 (MGI:5432296|PMID:22711842) RGD PMID:22711842 MGI:5432296 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
G Wnt11 Wnt family member 11 involved_in ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294
JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P48615 (MGI:5424267|PMID:22569553)
Ensembl
RGD
PMID:22569553 GO_REF:0000107 MGI:5424267 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hand2 heart and neural crest derivatives expressed 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:4413411|PMID:19008477)
Ensembl
RGD
PMID:19008477 GO_REF:0000107 MGI:4413411 NCBI chr16:32,917,826...32,919,880
Ensembl chr16:32,917,823...32,919,891
JBrowse link
regulation of heart induction by regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mks1 MKS transition zone complex subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:4821832 (MGI:5811184|PMID:27340223)
Ensembl
RGD
PMID:27340223 GO_REF:0000107 MGI:5811184 NCBI chr10:72,655,921...72,667,007
Ensembl chr10:72,655,921...72,666,655
JBrowse link
transforming growth factor beta receptor signaling pathway involved in heart development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 involved_in ISO (MGI:67103|PMID:8009224) RGD PMID:8009224 MGI:67103 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19541
    signaling 7512
      signal transduction 6927
        cell surface receptor signaling pathway 2812
          cell surface receptor signaling pathway involved in heart development 29
            BMP signaling pathway involved in heart development + 8
            Notch signaling involved in heart development + 5
            Wnt signaling pathway involved in heart development + 14
            activin receptor signaling pathway involved in heart jogging 0
            fibroblast growth factor receptor signaling pathway involved in heart development + 0
            semaphorin-plexin signaling pathway involved in outflow tract morphogenesis + 1
            smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation 1
            transforming growth factor beta receptor signaling pathway involved in heart development + 1
Path 2
Term Annotations click to browse term
  biological_process 19541
    developmental process 6920
      anatomical structure development 6337
        multicellular organism development 5765
          system development 5408
            animal organ development 4163
              heart development 701
                cell surface receptor signaling pathway involved in heart development 29
                  BMP signaling pathway involved in heart development + 8
                  Notch signaling involved in heart development + 5
                  Wnt signaling pathway involved in heart development + 14
                  activin receptor signaling pathway involved in heart jogging 0
                  fibroblast growth factor receptor signaling pathway involved in heart development + 0
                  semaphorin-plexin signaling pathway involved in outflow tract morphogenesis + 1
                  smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation 1
                  transforming growth factor beta receptor signaling pathway involved in heart development + 1
paths to the root