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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac neural crest cell differentiation involved in heart development
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Accession:GO:0061307 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches.


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canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2156191 (MGI:4413394|PMID:19705442) RGD PMID:19705442 MGI:4413394 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
cardiac neural crest cell development involved in heart development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 acts_upstream_of_or_within ISO MGI:2179740 (MGI:2179743|PMID:11694877) RGD PMID:11694877 MGI:2179743 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Mapk1 mitogen activated protein kinase 1 acts_upstream_of_or_within ISO MGI:1346859 (MGI:3832113|PMID:18952847) RGD PMID:18952847 MGI:3832113 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 acts_upstream_of_or_within ISO MGI:1346858 (MGI:3832113|PMID:18952847) RGD PMID:18952847 MGI:3832113 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
cardiac neural crest cell development involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III acts_upstream_of_or_within ISO MGI:3589208 (MGI:4849577|PMID:21098571) RGD PMID:21098571 MGI:4849577 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in ISO (MGI:4413411|PMID:19008477) RGD PMID:19008477 MGI:4413411 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:4354447|PMID:19609448)
Ensembl
RGD
PMID:19609448 GO_REF:0000107 MGI:4354447 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:4359139|PMID:19509466)
Ensembl
RGD
PMID:19509466 GO_REF:0000107 MGI:4359139 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Twist1 twist family bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:1857265 (MGI:3805126|PMID:18539270) RGD PMID:18539270 MGI:3805126 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
cardiac neural crest cell migration involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folr1 folate receptor alpha involved_in ISO (MGI:3721767|PMID:17286298) RGD PMID:17286298 MGI:3721767 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2386570|MGI:3803647 (MGI:4453274|PMID:20144608)
Ensembl
RGD
PMID:20144608 GO_REF:0000107 MGI:4453274 NCBI chr16:36,371,489...36,373,551
Ensembl chr16:36,371,489...36,373,546
JBrowse link
G Nrp1 neuropilin 1 NOT|involved_in ISO (MGI:5693177|PMID:26053665) RGD PMID:26053665 MGI:5693177 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Pitx2 paired-like homeodomain 2 involved_in ISO (MGI:2446944|PMID:12464179) RGD PMID:12464179 MGI:2446944 NCBI chr 2:233,602,732...233,621,059
Ensembl chr 2:233,602,732...233,621,129
JBrowse link
G Twist1 twist family bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:1857265 (MGI:3805126|PMID:18539270) RGD PMID:18539270 MGI:3805126 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
neural crest cell migration involved in heart formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folr1 folate receptor alpha involved_in ISO (MGI:3721767|PMID:17286298) RGD PMID:17286298 MGI:3721767 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P23359 (MGI:5502250|PMID:23863481)
Ensembl
RGD
PMID:23863481 GO_REF:0000107 MGI:5502250 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in ISO UniProtKB:P21275 (MGI:5502250|PMID:23863481) RGD PMID:23863481 MGI:5502250 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Sema3c semaphorin 3C involved_in ISO (MGI:5693177|PMID:26053665) RGD PMID:26053665 MGI:5693177 NCBI chr 4:14,318,276...14,490,438
Ensembl chr 4:14,318,274...14,490,446
JBrowse link
regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eng endoglin NOT|involved_in ISO (MGI:3721185|PMID:17628518) RGD PMID:17628518 MGI:3721185 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    cellular process 18457
      cellular developmental process 4459
        cell differentiation 4363
          cardiocyte differentiation 184
            cardiac neural crest cell differentiation involved in heart development 16
              canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development 1
              cardiac neural crest cell development involved in heart development + 15
Path 2
Term Annotations click to browse term
  biological_process 19612
    developmental process 6790
      anatomical structure development 6263
        multicellular organism development 5744
          system development 5287
            animal organ development 4053
              mesenchyme development 295
                mesenchymal cell differentiation 235
                  neural crest cell differentiation 96
                    cardiac neural crest cell differentiation involved in heart development 16
                      canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development 1
                      cardiac neural crest cell development involved in heart development + 15
paths to the root