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ONTOLOGY REPORT - ANNOTATIONS


Term:canonical Wnt signaling pathway involved in metanephric kidney development
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Accession:GO:0061290 term browser browse the term
Definition:The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Synonyms:exact_synonym: canonical Wnt receptor signaling pathway involved in metanephric kidney development;   canonical Wnt receptor signalling pathway involved in metanephric kidney development;   canonical Wnt-activated signaling pathway involved in metanephric kidney development



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canonical Wnt signaling pathway involved in metanephric kidney development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata3 GATA binding protein 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:3822373|PMID:19112489)
UniProt
RGD
PMID:19112489 GO_REF:0000024 MGI:3822373 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 involved_in ISO (MGI:5006869|PMID:21523854) RGD PMID:21523854 MGI:5006869 NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19834
    signaling 7588
      cell-cell signaling 1765
        cell-cell signaling involved in kidney development 2
          Wnt signaling pathway involved in kidney development 2
            canonical Wnt signaling pathway involved in metanephric kidney development 2
              canonical Wnt signaling pathway involved in ureteric bud branching 0
Path 2
Term Annotations click to browse term
  biological_process 19834
    developmental process 6965
      anatomical structure development 6376
        multicellular organism development 5800
          system development 5439
            urogenital system development 445
              renal system development 397
                kidney development 383
                  cell-cell signaling involved in kidney development 2
                    Wnt signaling pathway involved in kidney development 2
                      canonical Wnt signaling pathway involved in metanephric kidney development 2
                        canonical Wnt signaling pathway involved in ureteric bud branching 0
paths to the root