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Term:3'-UTR-mediated mRNA destabilization
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Accession:GO:0061158 term browser browse the term
Definition:An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.

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3'-UTR-mediated mRNA destabilization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPEB3 cytoplasmic polyadenylation element binding protein 3 IEA Ensembl GO_REF:0000107 NCBI chr28:6,523,894...6,724,010
Ensembl chr28:6,529,212...6,723,454
JBrowse link
G DHX36 DEAH-box helicase 36 IEA Ensembl GO_REF:0000107 NCBI chr23:48,404,351...48,456,360
Ensembl chr23:48,407,316...48,456,654
JBrowse link
G DND1 DND microRNA-mediated repression inhibitor 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:35,825,154...35,827,913
Ensembl chr 2:35,825,636...35,827,840
JBrowse link
G HNRNPD heterogeneous nuclear ribonucleoprotein D ISO RGD PMID:20805360 RGD:10042974 NCBI chr32:6,323,444...6,341,238
Ensembl chr32:6,323,469...6,341,166
JBrowse link
G KHSRP KH-type splicing regulatory protein IEA Ensembl GO_REF:0000107 NCBI chr20:53,746,656...53,755,388
Ensembl chr20:53,745,742...53,756,870
JBrowse link
G MOV10 Mov10 RISC complex RNA helicase IEA Ensembl GO_REF:0000107 NCBI chr17:62,872,607...62,896,208
Ensembl chr17:62,872,756...62,896,395
JBrowse link
G PLEKHN1 pleckstrin homology domain containing N1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:56,193,824...56,202,340
Ensembl chr 5:56,194,583...56,202,293
JBrowse link
G QKI QKI, KH domain containing RNA binding ISO (MGI:MGI:5316962|PMID:20631256) MGI PMID:20631256 MGI:MGI:5316962 NCBI chr 1:51,800,294...51,956,891
Ensembl chr 1:51,800,309...51,952,714
JBrowse link
G RBM24 RNA binding motif protein 24 ISO (PMID:24375645) UniProtKB PMID:24375645 NCBI chr35:16,255,076...16,294,967 JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 IEA Ensembl GO_REF:0000107 NCBI chr 7:25,265,836...25,312,417
Ensembl chr 7:25,233,235...25,305,174
JBrowse link
G TARDBP TAR DNA binding protein IEA Ensembl GO_REF:0000107 NCBI chr 2:84,987,752...84,998,136
Ensembl chr 2:84,989,952...84,998,593
JBrowse link
G TRIM71 tripartite motif containing 71 IEA Ensembl GO_REF:0000107 NCBI chr23:3,888,287...3,959,910
Ensembl chr23:3,893,647...3,960,411
JBrowse link
G UPF1 UPF1 RNA helicase and ATPase IEA Ensembl GO_REF:0000107 NCBI chr20:44,234,411...44,271,129
Ensembl chr20:44,236,264...44,270,916
JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A IBA
(PMID:21873635) GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr15:4,972,369...4,984,218
Ensembl chr15:4,972,956...4,980,371
JBrowse link
G ZC3H12D zinc finger CCCH-type containing 12D ISO (MGI:MGI:5707103|PMID:26134560) UniProtKB PMID:26134560 MGI:MGI:5707103 NCBI chr 1:40,249,856...40,279,344
Ensembl chr 1:40,259,705...40,279,888
JBrowse link
G ZFP36 ZFP36 ring finger protein IEA Ensembl GO_REF:0000107 NCBI chr 1:113,815,972...113,818,093
Ensembl chr 1:113,816,273...113,818,065
JBrowse link
G ZFP36L1 ZFP36 ring finger protein like 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:42,663,287...42,668,665
Ensembl chr 8:42,664,223...42,668,514
JBrowse link
G ZFP36L2 ZFP36 ring finger protein like 2 IEA Ensembl GO_REF:0000107 NCBI chr10:45,746,952...45,751,268
Ensembl chr10:45,748,936...45,751,250
JBrowse link

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Path 1
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  biological_process 16162
    biological regulation 11529
      regulation of biological quality 4009
        regulation of RNA stability 120
          regulation of mRNA stability 109
            mRNA destabilization 33
              3'-UTR-mediated mRNA destabilization 18
Path 2
Term Annotations click to browse term
  biological_process 16162
    metabolic process 10639
      cellular metabolic process 9632
        cellular aromatic compound metabolic process 5109
          nucleobase-containing compound metabolic process 4907
            nucleic acid metabolic process 4459
              RNA metabolic process 4001
                regulation of RNA metabolic process 3278
                  positive regulation of RNA metabolic process 1731
                    positive regulation of mRNA metabolic process 86
                      positive regulation of mRNA catabolic process 52
                        mRNA destabilization 33
                          3'-UTR-mediated mRNA destabilization 18
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.