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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of protein tyrosine kinase activity
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Accession:GO:0061097 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity.


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regulation of protein tyrosine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgb3 integrin subunit beta 3 ISO (MGI:MGI:5462513|PMID:22984613) MGI PMID:22984613 MGI:MGI:5462513 NCBI chrNW_004955478:9,788,192...9,830,254 JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C ISO (PMID:12100025) ARUK-UCL PMID:12100025 NCBI chrNW_004955406:35,005,577...35,127,395 JBrowse link
G Rap2b RAP2B, member of RAS oncogene family ISO (MGI:MGI:3822406|PMID:19061864) UniProtKB PMID:19061864 MGI:MGI:3822406 NCBI chrNW_004955448:4,668,477...4,671,629 JBrowse link
G Rap2c RAP2C, member of RAS oncogene family ISO (MGI:MGI:3822406|PMID:19061864) UniProtKB PMID:19061864 MGI:MGI:3822406 NCBI chrNW_004955473:2,709,407...2,723,453 JBrowse link
negative regulation of brain-derived neurotrophic factor-activated receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fam72a family with sequence similarity 72 member A ISO PMID:19755123 MGI PMID:19755123 RGD:8553945 NCBI chrNW_004955406:41,788,278...41,801,141 JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cblc Cbl proto-oncogene C ISO (PMID:10362357) BHF-UCL PMID:10362357 NCBI chrNW_004955555:1,921,896...1,941,247 JBrowse link
G Chmp6 charged multivesicular body protein 6 ISO (PMID:16973552) UniProtKB PMID:16973552 NCBI chrNW_004955506:1,987,710...1,994,731 JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 ISO (PMID:18046415)
PMID:17599051
(MGI:MGI:3629275|PMID:16648858)
UniProtKB
UniProt
PMID:16648858, PMID:17599051, PMID:18046415 MGI:MGI:3629275, RGD:8553726 NCBI chrNW_004955486:4,941,143...4,955,693 JBrowse link
G Gprc5a G protein-coupled receptor class C group 5 member A ISO (MGI:MGI:5635952|PMID:25744720) UniProtKB PMID:25744720 MGI:MGI:5635952 NCBI chrNW_004955413:9,765,564...9,784,847 JBrowse link
G Psen1 presenilin 1 ISO (MGI:MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:MGI:4887523 NCBI chrNW_004955523:2,128,529...2,210,737 JBrowse link
G Psen2 presenilin 2 ISO (MGI:MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:MGI:4887523 NCBI chrNW_004955406:5,727,367...5,748,798 JBrowse link
G Socs4 suppressor of cytokine signaling 4 ISO (PMID:15590694) UniProtKB PMID:15590694 NCBI chrNW_004955409:8,522,540...8,539,551 JBrowse link
G Socs5 suppressor of cytokine signaling 5 ISO (PMID:15590694) UniProtKB PMID:15590694 NCBI chrNW_004955441:13,593,342...13,657,389 JBrowse link
G Tsg101 tumor susceptibility 101 ISO (PMID:16973552) UniProtKB PMID:16973552 NCBI chrNW_004955414:33,154,812...33,193,769 JBrowse link
G Vps25 vacuolar protein sorting 25 homolog ISO (PMID:16973552) UniProtKB PMID:16973552 NCBI chrNW_004955451:16,589,509...16,593,730 JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 ISO (PMID:19460345) UniProtKB PMID:19460345 NCBI chrNW_004955514:1,366,186...1,450,982 JBrowse link
G Zgpat zinc finger CCCH-type and G-patch domain containing ISO (PMID:19644445) UniProtKB PMID:19644445 NCBI chrNW_004955528:493,051...519,780 JBrowse link
negative regulation of non-membrane spanning protein tyrosine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dusp22 dual specificity phosphatase 22 ISO (PMID:20018849) ARUK-UCL PMID:20018849 NCBI chrNW_004955465:12,551,063...12,597,386 JBrowse link
negative regulation of protein tyrosine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 ISO (MGI:MGI:5607357|PMID:25017399)
(PMID:25006397)
BHF-UCL PMID:25006397, PMID:25017399 MGI:MGI:5607357 NCBI chrNW_004955432:22,258,262...22,292,403 JBrowse link
G Ggnbp2 gametogenetin binding protein 2 ISO (MGI:MGI:5779255|PMID:26764350) MGI PMID:26764350 MGI:MGI:5779255 NCBI chrNW_004955451:1,345,720...1,386,100 JBrowse link
G Hyal2 hyaluronidase 2 ISO (PMID:12676986) UniProtKB PMID:12676986 NCBI chrNW_004955532:2,120,781...2,125,083 JBrowse link
G Mvp major vault protein ISO (PMID:16441665) UniProtKB PMID:16441665 NCBI chrNW_004955493:7,113,194...7,141,944 JBrowse link
G Ptk6 protein tyrosine kinase 6 ISO (PMID:15539407) UniProtKB PMID:15539407 NCBI chrNW_004955528:687,996...695,596 JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 ISO (MGI:MGI:5619464|PMID:21216966) ParkinsonsUK-UCL PMID:21216966 MGI:MGI:5619464 NCBI chrNW_004955402:771,410...846,671 JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C ISO (MGI:MGI:3530407|PMID:15661907) ARUK-UCL PMID:15661907 MGI:MGI:3530407 NCBI chrNW_004955406:35,005,577...35,127,395 JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 ISO (PMID:17525734) UniProtKB PMID:17525734 NCBI chrNW_004955451:13,673,613...13,734,639 JBrowse link
G Thy1 Thy-1 cell surface antigen ISO PMID:22479590 UniProt PMID:22479590 RGD:12793046 NCBI chrNW_004955412:20,480,284...20,484,958 JBrowse link
positive regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO (PMID:17655843)
(PMID:18483258)
BHF-UCL PMID:17655843, PMID:18483258 NCBI chrNW_004955487:5,180,241...5,218,298 JBrowse link
G Adora1 adenosine A1 receptor ISO RGD PMID:19574994 RGD:2317913 NCBI chrNW_004955406:39,148,811...39,183,577 JBrowse link
G Adra2a adrenoceptor alpha 2A ISO (PMID:17655843) BHF-UCL PMID:17655843 NCBI chrNW_004955485:384,405...387,332 JBrowse link
G Egf epidermal growth factor ISO (PMID:15611079), (PMID:20353436)
(PMID:22732145)
HGNC
ParkinsonsUK-UCL
PMID:15611079, PMID:20353436, PMID:22732145 NCBI chrNW_004955496:325,954...401,430 JBrowse link
G Epgn epithelial mitogen ISO (PMID:15611079)
(MGI:MGI:1934957|PMID:11278323)
HGNC PMID:11278323, PMID:15611079 MGI:MGI:1934957 NCBI chrNW_004955474:564,329...573,014 JBrowse link
G Ereg epiregulin ISO PMID:9990076 UniProt PMID:9990076 RGD:632743 NCBI chrNW_004955474:612,440...627,606 JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 ISO (PMID:20208556) BHF-UCL PMID:20208556 NCBI chrNW_004955471:6,852,459...7,026,590 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO (PMID:26514923) CAFA PMID:26514923 NCBI chrNW_004955456:13,353,780...13,363,956 JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 ISO (MGI:MGI:2149168|PMID:11481456) MGI PMID:11481456 MGI:MGI:2149168 NCBI chrNW_004955485:7,015,969...7,046,089 JBrowse link
G Tgfa transforming growth factor alpha ISO (PMID:11278323) HGNC PMID:11278323 NCBI chrNW_004955424:14,616,390...14,709,723 JBrowse link
positive regulation of non-membrane spanning protein tyrosine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISO (MGI:MGI:5888970|PMID:27994061) MGI PMID:27994061 MGI:MGI:5888970 NCBI chrNW_004955403:49,394,173...49,485,881 JBrowse link
G Stap1 signal transducing adaptor family member 1 ISO (PMID:10518561) BHF-UCL PMID:10518561 NCBI chrNW_004955447:5,292,708...5,345,214 JBrowse link
positive regulation of protein tyrosine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrn agrin ISO (MGI:MGI:4352602|PMID:19376779) BHF-UCL PMID:19376779 MGI:MGI:4352602 NCBI chrNW_004955486:9,674,103...9,704,994 JBrowse link
G Agt angiotensinogen ISO (PMID:15153556) UniProtKB PMID:15153556 NCBI chrNW_004955492:7,863,662...7,874,863 JBrowse link
G App amyloid beta precursor protein ISO (PMID:15190117) ARUK-UCL PMID:15190117 NCBI chrNW_004955407:25,725,259...25,973,582 JBrowse link
G Cass4 Cas scaffold protein family member 4 ISO (PMID:18256281) UniProtKB PMID:18256281 NCBI chrNW_004955445:2,771,130...2,809,815 JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO (PMID:7681396) UniProtKB PMID:7681396 NCBI chrNW_004955415:4,434,486...4,462,505 JBrowse link
G Dlg3 discs large MAGUK scaffold protein 3 ISO PMID:17526495 ARUK-UCL PMID:17526495 RGD:13506268 NCBI chrNW_004955475:9,992,888...10,056,197 JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 ISO PMID:17526495 ARUK-UCL PMID:17526495 RGD:13506268 NCBI chrNW_004955467:9,691,733...9,715,872 JBrowse link
G Dok7 docking protein 7 ISO (MGI:MGI:4820894|PMID:20603078)
(PMID:20603078)
UniProtKB PMID:20603078 MGI:MGI:4820894 NCBI chrNW_004955514:2,166,263...2,190,211 JBrowse link
G Dvl2 dishevelled segment polarity protein 2 ISO (MGI:MGI:4414728|PMID:19920076) MGI PMID:19920076 MGI:MGI:4414728 NCBI chrNW_004955467:9,675,912...9,683,996 JBrowse link
G Efna1 ephrin A1 ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955545:1,610,929...1,617,217 JBrowse link
G Egf epidermal growth factor ISO (MGI:MGI:52273|PMID:7678348) MGI PMID:7678348 MGI:MGI:52273 NCBI chrNW_004955496:325,954...401,430 JBrowse link
G Epha4 EPH receptor A4 ISO (MGI:MGI:5588508|PMID:24658113) ARUK-UCL PMID:24658113 MGI:MGI:5588508 NCBI chrNW_004955453:12,099,800...12,240,199 JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO (PMID:7556068) BHF-UCL PMID:7556068 NCBI chrNW_004955458:3,683,126...3,701,752 JBrowse link
G Gas6 growth arrest specific 6 ISO (PMID:20103767) UniProtKB PMID:20103767 NCBI chrNW_004955404:276,397...303,864 JBrowse link
G Gprc5b G protein-coupled receptor class C group 5 member B ISO (MGI:MGI:5545939|PMID:23169819) UniProtKB PMID:23169819 MGI:MGI:5545939 NCBI chrNW_004955442:3,548,478...3,571,341 JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist ISO (MGI:MGI:3834346|PMID:17077323) BHF-UCL PMID:17077323 MGI:MGI:3834346 NCBI chrNW_004955416:1,812,725...1,825,528 JBrowse link
G Grm5 glutamate metabotropic receptor 5 ISO PMID:24012003
(MGI:MGI:5515653|PMID:24012003)
ARUK-UCL PMID:24012003 MGI:MGI:5515653, RGD:8553716 NCBI chrNW_004955414:4,424,245...4,919,399 JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 ISO (MGI:MGI:4422145|PMID:19754877) MGI PMID:19754877 MGI:MGI:4422145 NCBI chrNW_004955431:14,680,364...14,706,182 JBrowse link
G Il34 interleukin 34 ISO (PMID:26754294) ARUK-UCL PMID:26754294 NCBI chrNW_004955484:3,362,240...3,429,031 JBrowse link
G Lrp8 LDL receptor related protein 8 ISO (MGI:MGI:5426130|PMID:21852430) BHF-UCL PMID:21852430 MGI:MGI:5426130 NCBI chrNW_004955464:5,837,002...5,912,178 JBrowse link
G Ncapg2 non-SMC condensin II complex subunit G2 ISO (MGI:MGI:3640711|PMID:16673016) MGI PMID:16673016 MGI:MGI:3640711 NCBI chrNW_004955579:896,507...955,515 JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 ISO (PMID:18256281) UniProtKB PMID:18256281 NCBI chrNW_004955465:3,101,409...3,281,481 JBrowse link
G Nox4 NADPH oxidase 4 ISO (MGI:MGI:5811735|PMID:27525436) ARUK-UCL PMID:27525436 MGI:MGI:5811735 NCBI chrNW_004955414:4,062,337...4,220,032 JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO (PMID:16530387) UniProtKB PMID:16530387 NCBI chrNW_004955413:25,150,702...25,166,987 JBrowse link
G Prnp prion protein ISO (PMID:24012003) ARUK-UCL PMID:24012003 NCBI chrNW_004955415:15,442,313...15,454,644 JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 ISO (PMID:21216966) ParkinsonsUK-UCL PMID:21216966 NCBI chrNW_004955445:7,754,313...7,819,229 JBrowse link
G Reln reelin ISO (MGI:MGI:5426130|PMID:21852430) CACAO PMID:21852430 MGI:MGI:5426130 NCBI chrNW_004955410:8,424,439...8,863,966 JBrowse link
G Srcin1 SRC kinase signaling inhibitor 1 ISO (PMID:17525734) UniProtKB PMID:17525734 NCBI chrNW_004955451:13,673,613...13,734,639 JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor ISO (MGI:MGI:3640711|PMID:16673016) MGI PMID:16673016 MGI:MGI:3640711 NCBI chrNW_004955464:11,304,611...11,317,420 JBrowse link
G Tcf3 transcription factor 3 ISO (MGI:MGI:3640711|PMID:16673016) MGI PMID:16673016 MGI:MGI:3640711 NCBI chrNW_004955495:6,337,311...6,365,193 JBrowse link
G Trpv4 transient receptor potential cation channel subfamily V member 4 ISO (PMID:22492652) AgBase PMID:22492652 NCBI chrNW_004955455:8,744,865...8,781,644 JBrowse link
G Unc119 unc-119 lipid binding chaperone ISO (PMID:14757743) UniProtKB PMID:14757743 NCBI chrNW_004955481:4,597,839...4,603,313 JBrowse link
G Wnt3a Wnt family member 3A ISO (MGI:MGI:4414728|PMID:19920076) MGI PMID:19920076 MGI:MGI:4414728 NCBI chrNW_004955581:351,375...382,541 JBrowse link
regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplp2 amyloid beta precursor like protein 2 ISO (MGI:MGI:3714214|PMID:17556541) MGI PMID:17556541 MGI:MGI:3714214 NCBI chrNW_004955412:31,043,320...31,075,617 JBrowse link
G App amyloid beta precursor protein ISO (MGI:MGI:3714214|PMID:17556541) MGI PMID:17556541 MGI:MGI:3714214 NCBI chrNW_004955407:25,725,259...25,973,582 JBrowse link
G Psen1 presenilin 1 ISO (MGI:MGI:3714214|PMID:17556541) MGI PMID:17556541 MGI:MGI:3714214 NCBI chrNW_004955523:2,128,529...2,210,737 JBrowse link
G Psen2 presenilin 2 ISO (MGI:MGI:3714214|PMID:17556541) MGI PMID:17556541 MGI:MGI:3714214 NCBI chrNW_004955406:5,727,367...5,748,798 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11862
    biological regulation 8697
      regulation of molecular function 2145
        regulation of catalytic activity 1493
          regulation of transferase activity 772
            regulation of kinase activity 671
              regulation of protein kinase activity 610
                regulation of protein tyrosine kinase activity 70
                  negative regulation of protein tyrosine kinase activity + 23
                  positive regulation of protein tyrosine kinase activity + 44
                  regulation of brain-derived neurotrophic factor-activated receptor activity + 1
                  regulation of epidermal growth factor-activated receptor activity + 24
                  regulation of non-membrane spanning protein tyrosine kinase activity + 3
Path 2
Term Annotations click to browse term
  biological_process 11862
    metabolic process 7593
      organic substance metabolic process 7299
        macromolecule metabolic process 6337
          protein metabolic process 3840
            protein modification process 2865
              cellular protein modification process 2865
                peptidyl-amino acid modification 985
                  peptidyl-tyrosine modification 304
                    peptidyl-tyrosine phosphorylation 301
                      regulation of peptidyl-tyrosine phosphorylation 250
                        regulation of protein tyrosine kinase activity 70
                          negative regulation of protein tyrosine kinase activity + 23
                          positive regulation of protein tyrosine kinase activity + 44
                          regulation of brain-derived neurotrophic factor-activated receptor activity + 1
                          regulation of epidermal growth factor-activated receptor activity + 24
                          regulation of non-membrane spanning protein tyrosine kinase activity + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.