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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of cartilage development
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Accession:GO:0061037 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


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negative regulation of cartilage development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTSK cathepsin K involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19834056) Ensembl
MGI		 PMID:19834056 GO_REF:0000107 NCBI chr 1:126,146,555...126,158,662
Ensembl chr 1:129,795,966...129,808,316 		JBrowse link
G FRZB frizzled related protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18991062) Ensembl
MGI		 PMID:18991062 GO_REF:0000107 NCBI chr2B:70,106,378...70,139,333
Ensembl chr2B:187,915,579...187,948,855 		JBrowse link
G IDUA alpha-L-iduronidase acts_upstream_of_or_within ISO (PMID:19834056) MGI PMID:19834056 NCBI chr 4:1,102,288...1,120,973
Ensembl chr 4:1,020,582...1,037,877 		JBrowse link
G LEP leptin ISO RGD PMID:19876764 RGD:5128612 NCBI chr 7:120,230,896...120,248,602
Ensembl chr 7:132,885,011...132,901,519 		JBrowse link
G NOG noggin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10684250) Ensembl
MGI		 PMID:10684250 GO_REF:0000107 NCBI chr17:50,669,186...50,671,081
Ensembl chr17:55,532,394...55,533,092 		JBrowse link
G RARA retinoic acid receptor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10684250) Ensembl
MGI		 PMID:10684250 GO_REF:0000107 NCBI chr17:16,932,485...16,980,958 JBrowse link
G RARB retinoic acid receptor beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10684250) Ensembl
MGI		 PMID:10684250 GO_REF:0000107 NCBI chr 3:24,729,220...25,499,187
Ensembl chr 3:25,660,922...25,833,297 		JBrowse link
G RARG retinoic acid receptor gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10684250) Ensembl
MGI		 PMID:10684250 GO_REF:0000107 NCBI chr12:35,521,276...35,542,814
Ensembl chr12:36,303,359...36,325,111 		JBrowse link
G TGFB2 transforming growth factor beta 2 acts_upstream_of_or_within ISO (PMID:21780244) MGI PMID:21780244 NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041 		JBrowse link
G WNT9A Wnt family member 9A acts_upstream_of_or_within ISO (PMID:19047045) MGI PMID:19047045 NCBI chr 1:203,320,990...203,350,599
Ensembl chr 1:208,300,609...208,327,191 		JBrowse link
negative regulation of chondrocyte development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTHLH parathyroid hormone like hormone acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:90087) MGI
Ensembl		 PMID:90087 GO_REF:0000107 NCBI chr12:58,341,361...58,355,804
Ensembl chr12:60,960,071...60,973,750 		JBrowse link
G RFLNA refilin A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24436304) TreeGrafter
MGI		 PMID:24436304 GO_REF:0000118 NCBI chr12:121,737,946...121,903,635
Ensembl chr12:126,164,592...126,191,071 		JBrowse link
G RFLNB refilin B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24436304) Ensembl
MGI
TreeGrafter		 PMID:24436304 GO_REF:0000107 GO_REF:0000118 NCBI chr17:359,016...367,464
Ensembl chr17:375,885...381,580 		JBrowse link
negative regulation of chondrocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:76,442,053...76,818,726
Ensembl chr 5:81,827,560...82,199,840 		JBrowse link
G ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif 7 involved_in ISO (PMID:22247065) BHF-UCL PMID:22247065 NCBI chr15:61,291,451...61,295,148 JBrowse link
G BMP4 bone morphogenetic protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17481601) Ensembl
MGI		 PMID:17481601 GO_REF:0000107 NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752 		JBrowse link
G CCN4 cellular communication network factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:129,842,580...129,884,528
Ensembl chr 8:132,818,397...132,858,861 		JBrowse link
G CHADL chondroadherin like involved_in ISO (MGI:5617405|PMID:25451920) UniProt PMID:25451920 MGI:5617405 NCBI chr22:22,106,953...22,138,122 JBrowse link
G CTNNB1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16818445)
(PMID:15866163)		 Ensembl
MGI		 PMID:15866163 PMID:16818445 GO_REF:0000107 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030 		JBrowse link
G EFEMP1 EGF containing fibulin extracellular matrix protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:56,017,678...56,076,059
Ensembl chr2A:57,155,000...57,212,500 		JBrowse link
G GDF5 growth differentiation factor 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:31,761,199...31,766,229
Ensembl chr20:32,882,094...32,886,899 		JBrowse link
G GLI2 GLI family zinc finger 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17328886) Ensembl
MGI		 PMID:17328886 GO_REF:0000107 NCBI chr2B:7,665,403...7,922,840
Ensembl chr2B:121,303,831...121,497,442 		JBrowse link
G GLI3 GLI family zinc finger 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16284117) Ensembl
MGI		 PMID:16284117 GO_REF:0000107 NCBI chr 7:42,004,965...42,280,772
Ensembl chr 7:42,056,565...42,322,865 		JBrowse link
G GREM1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:10556075) AgBase PMID:10556075 NCBI chr15:11,213,870...11,230,619 JBrowse link
G IHH Indian hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16284117) Ensembl
MGI		 PMID:16284117 GO_REF:0000107 NCBI chr2B:106,312,472...106,319,124
Ensembl chr2B:224,906,271...224,911,506 		JBrowse link
G LOC100976854 A disintegrin and metalloproteinase with thrombospondin motifs 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:63,951,548...63,979,068
Ensembl chr15:76,692,416...76,735,344 		JBrowse link
G LTBP3 latent transforming growth factor beta binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11790802) Ensembl
MGI		 PMID:11790802 GO_REF:0000107 NCBI chr11:60,897,897...60,917,690
Ensembl chr11:64,233,504...64,252,802 		JBrowse link
G MKX mohawk homeobox ISO RGD PMID:27370800 RGD:40924660 NCBI chr10:27,820,454...27,893,373
Ensembl chr10:28,181,483...28,254,311 		JBrowse link
G NKX3-2 NK3 homeobox 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:7,958,218...7,961,844
Ensembl chr 4:13,258,949...13,262,458 		JBrowse link
G PTH parathyroid hormone involved_in ISO PMID:11604398 CAFA PMID:11604398 RGD:12793028 NCBI chr11:13,653,777...13,657,901
Ensembl chr11:13,347,838...13,351,802 		JBrowse link
G PTHLH parathyroid hormone like hormone acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:90087)
(PMID:17328886)
(PMID:8895385)		 MGI
Ensembl		 PMID:90087 PMID:8895385 PMID:17328886 GO_REF:0000107 NCBI chr12:58,341,361...58,355,804
Ensembl chr12:60,960,071...60,973,750 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in ISO (MGI:6414736|PMID:29644115) UniProt PMID:29644115 MGI:6414736 NCBI chr12:110,016,364...110,107,462
Ensembl chr12:113,435,669...113,503,762 		JBrowse link
G RARB retinoic acid receptor beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10684250) Ensembl
MGI		 PMID:10684250 GO_REF:0000107 NCBI chr 3:24,729,220...25,499,187
Ensembl chr 3:25,660,922...25,833,297 		JBrowse link
G RARG retinoic acid receptor gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10684250) Ensembl
MGI		 PMID:10684250 GO_REF:0000107 NCBI chr12:35,521,276...35,542,814
Ensembl chr12:36,303,359...36,325,111 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:45,341,857...45,345,544
Ensembl chr 8:42,723,971...42,730,904 		JBrowse link
G SOX9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO (PMID:11371614) MGI PMID:11371614 NCBI chr17:66,028,737...66,034,122 JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:70,195,007...70,243,514
Ensembl chr 9:98,332,739...98,362,748 		JBrowse link
G WNT9A Wnt family member 9A acts_upstream_of_or_within ISO (PMID:16818445) MGI PMID:16818445 NCBI chr 1:203,320,990...203,350,599
Ensembl chr 1:208,300,609...208,327,191 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    negative regulation of biological process 5559
      negative regulation of multicellular organismal process 1231
        negative regulation of cartilage development 34
          negative regulation of chondrocyte differentiation + 27
Path 2
Term Annotations click to browse term
  biological_process 16440
    developmental process 6563
      anatomical structure development 6172
        multicellular organism development 4975
          system development 4324
            skeletal system development 570
              cartilage development 237
                regulation of cartilage development 74
                  negative regulation of cartilage development 34
                    negative regulation of chondrocyte differentiation + 27
paths to the root