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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of cartilage development
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Accession:GO:0061037 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

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negative regulation of cartilage development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsk cathepsin K acts_upstream_of_or_within ISO MGI:2182131 (MGI:4397742|PMID:19834056) RGD PMID:19834056 MGI:4397742 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446 		JBrowse link
G Frzb frizzled-related protein acts_upstream_of_or_within ISO MGI:98958 (MGI:3823145|PMID:18991062) RGD PMID:18991062 MGI:3823145 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772 		JBrowse link
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO MGI:2176236 (MGI:4397742|PMID:19834056) RGD PMID:19834056 MGI:4397742 NCBI chr14:2,041,828...2,056,762
Ensembl chr14:2,042,411...2,056,762 		JBrowse link
G Lep leptin IDA RGD PMID:19876764 RGD:5128612 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Nog noggin acts_upstream_of_or_within
involved_in		 IEA
ISO		 GO_REF:0000107
(MGI:1353721|PMID:10684250)		 Ensembl
RGD		 PMID:10684250 GO_REF:0000107 MGI:1353721 NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386 		JBrowse link
G Rara retinoic acid receptor, alpha acts_upstream_of_or_within ISO (MGI:1353721|PMID:10684250) RGD PMID:10684250 MGI:1353721 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210 		JBrowse link
G Rarb retinoic acid receptor, beta acts_upstream_of_or_within ISO (MGI:1353721|PMID:10684250) RGD PMID:10684250 MGI:1353721 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599 		JBrowse link
G Rarg retinoic acid receptor, gamma acts_upstream_of_or_within ISO (MGI:1353721|PMID:10684250) RGD PMID:10684250 MGI:1353721 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of_or_within ISO MGI:1888389 (MGI:5140242|PMID:21780244) RGD PMID:21780244 MGI:5140242 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
G Wnt9a Wnt family member 9A acts_upstream_of_or_within ISO (MGI:3839710|PMID:19047045) RGD PMID:19047045 MGI:3839710 NCBI chr10:45,659,045...45,686,103
Ensembl chr10:45,659,143...45,681,393 		JBrowse link
negative regulation of chondrocyte development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pthlh parathyroid hormone-like hormone involved_in ISO (PMID:90087) RGD PMID:90087 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Rflna refilin A involved_in
acts_upstream_of_or_within		 ISO
IBA		 MGI:1923816 (MGI:5570967|PMID:24436304)
PMID:21873635		 RGD PMID:24436304, PMID:21873635, PMID:21873635 MGI:5570967, RGD:13792537, RGD:13792537 NCBI chr12:37,038,732...37,047,628
Ensembl chr12:37,038,733...37,047,628 		JBrowse link
G Rflnb refilin B acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:1920371 (MGI:5570967|PMID:24436304)
PMID:21873635		 RGD PMID:24436304, PMID:21873635, PMID:21873635 MGI:5570967, RGD:13792537, RGD:13792537 NCBI chr10:64,196,103...64,202,380
Ensembl chr10:64,196,127...64,202,380 		JBrowse link
negative regulation of chondrocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 involved_in ISO (PMID:22247065) RGD PMID:22247065 NCBI chr 2:61,039,072...61,340,687
Ensembl chr 2:61,039,053...61,340,697 		JBrowse link
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 involved_in ISO (PMID:22247065) RGD PMID:22247065 NCBI chr 8:97,535,777...97,575,661
Ensembl chr 8:97,535,777...97,575,655 		JBrowse link
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within
involved_in		 IEA
ISO		 GO_REF:0000107
(MGI:3714677|PMID:17481601)		 Ensembl
RGD		 PMID:17481601 GO_REF:0000107 MGI:3714677 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Ccn4 cellular communication network factor 4 involved_in IEA
ISO		 GO_REF:0000107
(MGI:6294593|PMID:15331410)		 Ensembl
RGD		 PMID:15331410 GO_REF:0000107 MGI:6294593 NCBI chr 7:107,695,227...107,723,759
Ensembl chr 7:107,695,215...107,723,772 		JBrowse link
G Chadl chondroadherin-like involved_in ISO (MGI:5617405|PMID:25451920) RGD PMID:25451920 MGI:5617405 NCBI chr 7:122,915,847...122,929,127
Ensembl chr 7:122,922,022...122,926,336 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within
involved_in		 IEA
ISO		 GO_REF:0000107
MGI:2446084 (MGI:3701031|PMID:16818445)		 Ensembl
RGD		 PMID:16818445 GO_REF:0000107 MGI:3701031 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:20005202)		 Ensembl
UniProt
RGD		 PMID:20005202 GO_REF:0000024 GO_REF:0000107 NCBI chr14:113,202,382...113,294,993
Ensembl chr14:113,202,419...113,295,014 		JBrowse link
G Gdf5 growth differentiation factor 5 involved_in ISO (PMID:21976273) RGD PMID:21976273 NCBI chr 3:151,482,672...151,487,129
Ensembl chr 3:151,483,249...151,486,693 		JBrowse link
G Gli2 GLI family zinc finger 2 acts_upstream_of_or_within ISO MGI:1857509 (MGI:3709778|PMID:17328886) RGD PMID:17328886 MGI:3709778 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:10556075) RGD PMID:10556075 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989 		JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (MGI:2178869|PMID:11790802) RGD PMID:11790802 MGI:2178869 NCBI chr 1:221,099,155...221,116,096
Ensembl chr 1:221,099,998...221,116,096 		JBrowse link
G Nkx3-2 NK3 homeobox 2 involved_in ISO (MGI:3617032|PMID:16421188) RGD PMID:16421188 MGI:3617032 NCBI chr14:73,813,531...73,818,489
Ensembl chr14:73,813,528...73,815,757 		JBrowse link
G Pth parathyroid hormone involved_in IMP PMID:11604398 CAFA PMID:11604398, PMID:11604398 RGD:12793028, RGD:12793028 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761 		JBrowse link
G Pthlh parathyroid hormone-like hormone acts_upstream_of_or_within
involved_in		 ISO (PMID:90087)
MGI:2154515|MGI:95728 (MGI:1352921|PMID:8895385), (MGI:3709778|PMID:17328886)		 RGD PMID:90087 PMID:8895385 PMID:17328886 MGI:1352921 MGI:3709778 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6414736|PMID:29644115)		 UniProt
RGD		 PMID:29644115 GO_REF:0000024 MGI:6414736 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999 		JBrowse link
G Rarb retinoic acid receptor, beta acts_upstream_of_or_within ISO (MGI:1353721|PMID:10684250) RGD PMID:10684250 MGI:1353721 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599 		JBrowse link
G Rarg retinoic acid receptor, gamma acts_upstream_of_or_within ISO (MGI:1353721|PMID:10684250) RGD PMID:10684250 MGI:1353721 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:19756381) RGD PMID:19756381 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797 		JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within
involved_in		 ISS
ISO		 GO_REF:0000024
MGI:2158693 (MGI:2135696|PMID:11371614)		 UniProt
RGD		 PMID:11371614 GO_REF:0000024 MGI:2135696 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO (MGI:3848261|PMID:19494318) RGD PMID:19494318 MGI:3848261 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635 		JBrowse link
G Wnt9a Wnt family member 9A acts_upstream_of_or_within ISO MGI:3701350|MGI:88267 (MGI:3701031|PMID:16818445) RGD PMID:16818445 MGI:3701031 NCBI chr10:45,659,045...45,686,103
Ensembl chr10:45,659,143...45,681,393 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20082
    negative regulation of biological process 5713
      negative regulation of multicellular organismal process 1133
        negative regulation of cartilage development 30
          negative regulation of chondrocyte differentiation + 23
Path 2
Term Annotations click to browse term
  biological_process 20082
    developmental process 6853
      anatomical structure development 6313
        multicellular organism development 5789
          system development 5317
            skeletal system development 556
              cartilage development 214
                regulation of cartilage development 71
                  negative regulation of cartilage development 30
                    negative regulation of chondrocyte differentiation + 23
paths to the root