ONTOLOGY REPORT - ANNOTATIONS
Term: negative regulation of cartilage development
Accession: GO:0061037
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Definition: Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
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Ctsk
cathepsin K
acts_upstream_of_or_within
ISO
MGI:2182131 (MGI:4397742|PMID:19834056)
RGD
PMID:19834056
MGI:4397742
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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Frzb
frizzled-related protein
acts_upstream_of_or_within
ISO
MGI:98958 (MGI:3823145|PMID:18991062)
RGD
PMID:18991062
MGI:3823145
NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208
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Idua
alpha-L-iduronidase
acts_upstream_of_or_within
ISO
MGI:2176236 (MGI:4397742|PMID:19834056)
RGD
PMID:19834056
MGI:4397742
NCBI chr14:1,031,588...1,059,494
Ensembl chr14:1,032,171...1,046,522
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Lep
leptin
IDA
RGD
PMID:19876764
RGD:5128612
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Mir21
microRNA 21
involved_in
ISO
(PMID:24577233)
RGD
PMID:24577233
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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Nog
noggin
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 (MGI:1353721|PMID:10684250)
Ensembl RGD
PMID:10684250
GO_REF:0000107 MGI:1353721
NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
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Rara
retinoic acid receptor, alpha
acts_upstream_of_or_within
ISO
(MGI:1353721|PMID:10684250)
RGD
PMID:10684250
MGI:1353721
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rarb
retinoic acid receptor, beta
acts_upstream_of_or_within
ISO
(MGI:1353721|PMID:10684250)
RGD
PMID:10684250
MGI:1353721
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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Rarg
retinoic acid receptor, gamma
acts_upstream_of_or_within
ISO
(MGI:1353721|PMID:10684250)
RGD
PMID:10684250
MGI:1353721
NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
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Tgfb2
transforming growth factor, beta 2
acts_upstream_of_or_within
ISO
MGI:1888389 (MGI:5140242|PMID:21780244)
RGD
PMID:21780244
MGI:5140242
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Wnt9a
Wnt family member 9A
acts_upstream_of_or_within
ISO
(MGI:3839710|PMID:19047045)
RGD
PMID:19047045
MGI:3839710
NCBI chr10:44,094,140...44,121,134
Ensembl chr10:44,094,140...44,121,133
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Pthlh
parathyroid hormone-like hormone
acts_upstream_of_or_within
ISO
(PMID:90087)
RGD
PMID:90087
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
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Rflna
refilin A
acts_upstream_of_or_within involved_in
ISO IBA
MGI:1923816 (MGI:5570967|PMID:24436304) PMID:21873635
RGD
PMID:24436304 PMID:21873635
MGI:5570967 , RGD:13792537
NCBI chr12:31,633,361...31,642,317
Ensembl chr12:31,633,361...31,642,317
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Rflnb
refilin B
involved_in acts_upstream_of_or_within
IBA ISO
PMID:21873635 MGI:1920371 (MGI:5570967|PMID:24436304)
RGD
PMID:24436304 PMID:21873635
MGI:5570967 , RGD:13792537
NCBI chr10:60,893,693...60,899,970
Ensembl chr10:60,893,713...60,899,976
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Adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
involved_in
ISO
(PMID:22247065)
RGD
PMID:22247065
NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629
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Adamts7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
involved_in
ISO
(PMID:22247065)
RGD
PMID:22247065
NCBI chr 8:90,704,727...90,744,331
Ensembl chr 8:90,704,727...90,744,328
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Bmp4
bone morphogenetic protein 4
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 (MGI:3714677|PMID:17481601)
Ensembl RGD
PMID:17481601
GO_REF:0000107 MGI:3714677
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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Ccn4
cellular communication network factor 4
involved_in
IEA ISO
GO_REF:0000107 (MGI:6294593|PMID:15331410)
Ensembl RGD
PMID:15331410
GO_REF:0000107 MGI:6294593
NCBI chr 7:98,645,238...98,677,253
Ensembl chr 7:98,645,182...98,677,248
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Chadl
chondroadherin-like
involved_in
ISO
(MGI:5617405|PMID:25451920)
RGD
PMID:25451920
MGI:5617405
NCBI chr 7:113,205,323...113,218,678
Ensembl chr 7:113,210,748...113,217,272
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Ctnnb1
catenin beta 1
acts_upstream_of_or_within involved_in
ISO IEA
MGI:2446084 (MGI:3701031|PMID:16818445) GO_REF:0000107 MGI:2148591|MGI:2148594|MGI:2446084|MGI:2450929 (MGI:3578464|PMID:15866163), (MGI:3701031|PMID:16818445)
RGD Ensembl
PMID:15866163 PMID:16818445
GO_REF:0000107 MGI:3578464 MGI:3701031
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Efemp1
EGF containing fibulin extracellular matrix protein 1
involved_in
ISO ISS
(PMID:20005202) GO_REF:0000024
RGD UniProt
PMID:20005202
GO_REF:0000024
NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018
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Gdf5
growth differentiation factor 5
involved_in
ISO
(PMID:21976273)
RGD
PMID:21976273
NCBI chr 3:144,454,306...144,458,757
Ensembl chr 3:144,454,338...144,458,612
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Gli2
GLI family zinc finger 2
acts_upstream_of_or_within
ISO
MGI:1857509 (MGI:3709778|PMID:17328886)
RGD
PMID:17328886
MGI:3709778
NCBI chr13:29,946,809...30,163,901
Ensembl chr13:29,946,809...30,163,574
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Gli3
GLI family zinc finger 3
acts_upstream_of_or_within
ISO
MGI:96533 (MGI:3608261|PMID:16284117)
RGD
PMID:16284117
MGI:3608261
NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712
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Grem1
gremlin 1, DAN family BMP antagonist
involved_in
ISO
(PMID:10556075)
RGD
PMID:10556075
NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
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Ihh
Indian hedgehog signaling molecule
acts_upstream_of_or_within
ISO
MGI:1934258 (MGI:3608261|PMID:16284117)
RGD
PMID:16284117
MGI:3608261
NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
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Ltbp3
latent transforming growth factor beta binding protein 3
acts_upstream_of_or_within
ISO
MGI:2180017 (MGI:2178869|PMID:11790802)
RGD
PMID:11790802
MGI:2178869
NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975
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Mkx
mohawk homeobox
IMP
RGD
PMID:27370800
RGD:40924660
NCBI chr17:55,077,073...55,156,877
Ensembl chr17:55,077,540...55,156,124
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Nkx3-2
NK3 homeobox 2
involved_in
ISO
(MGI:3617032|PMID:16421188)
RGD
PMID:16421188
MGI:3617032
NCBI chr14:69,183,795...69,186,182
Ensembl chr14:69,183,820...69,186,061
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Pth
parathyroid hormone
involved_in
IMP
PMID:11604398
CAFA
PMID:11604398
RGD:12793028
NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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Pthlh
parathyroid hormone-like hormone
acts_upstream_of_or_within
ISO
MGI:2154515|MGI:95728 (MGI:1352921|PMID:8895385), (MGI:3709778|PMID:17328886) (PMID:90087)
RGD
PMID:90087 PMID:8895385 PMID:17328886
MGI:1352921 MGI:3709778
NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
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Ptpn11
protein tyrosine phosphatase, non-receptor type 11
involved_in
ISS ISO
GO_REF:0000024 (MGI:6414736|PMID:29644115)
UniProt RGD
PMID:29644115
GO_REF:0000024 MGI:6414736
NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
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Rarb
retinoic acid receptor, beta
acts_upstream_of_or_within
ISO
(MGI:1353721|PMID:10684250)
RGD
PMID:10684250
MGI:1353721
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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Rarg
retinoic acid receptor, gamma
acts_upstream_of_or_within
ISO
(MGI:1353721|PMID:10684250)
RGD
PMID:10684250
MGI:1353721
NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
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Snai2
snail family transcriptional repressor 2
involved_in
ISO
(PMID:19756381)
RGD
PMID:19756381
NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
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Sox9
SRY-box transcription factor 9
involved_in acts_upstream_of_or_within
ISS ISO
GO_REF:0000024 MGI:2158693 (MGI:2135696|PMID:11371614)
UniProt RGD
PMID:11371614
GO_REF:0000024 MGI:2135696
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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Tgfbr1
transforming growth factor, beta receptor 1
involved_in
ISO
(MGI:3848261|PMID:19494318)
RGD
PMID:19494318
MGI:3848261
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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Wnt9a
Wnt family member 9A
acts_upstream_of_or_within
ISO
MGI:3701350|MGI:88276 (MGI:3701031|PMID:16818445)
RGD
PMID:16818445
MGI:3701031
NCBI chr10:44,094,140...44,121,134
Ensembl chr10:44,094,140...44,121,133
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