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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of cartilage development
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Accession:GO:0061037 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


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negative regulation of cartilage development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsk cathepsin K acts_upstream_of_or_within ISO MGI:2182131 (PMID:19834056) RGD PMID:19834056 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Frzb frizzled-related protein acts_upstream_of_or_within ISO MGI:98958 (PMID:18991062) RGD PMID:18991062 NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208 		JBrowse link
G Idua alpha-L-iduronidase acts_upstream_of_or_within ISO MGI:2176236 (PMID:19834056) RGD PMID:19834056 NCBI chr14:1,031,588...1,059,494
Ensembl chr14:1,032,171...1,046,522 		JBrowse link
G Lep leptin IDA RGD PMID:19876764 RGD:5128612 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:24577233) RGD PMID:24577233 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Nog noggin involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:10684250)		 Ensembl
RGD		 PMID:10684250 GO_REF:0000107 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Rara retinoic acid receptor, alpha acts_upstream_of_or_within ISO (PMID:10684250) RGD PMID:10684250 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rarb retinoic acid receptor, beta acts_upstream_of_or_within ISO (PMID:10684250) RGD PMID:10684250 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rarg retinoic acid receptor, gamma acts_upstream_of_or_within ISO (PMID:10684250) RGD PMID:10684250 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of_or_within ISO MGI:1888389 (PMID:21780244) RGD PMID:21780244 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Wnt9a Wnt family member 9A acts_upstream_of_or_within ISO (PMID:19047045) RGD PMID:19047045 NCBI chr10:44,094,140...44,121,134
Ensembl chr10:44,094,140...44,121,133 		JBrowse link
negative regulation of chondrocyte development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pthlh parathyroid hormone-like hormone acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:90087)
GO_REF:0000107		 RGD
Ensembl		 PMID:90087 GO_REF:0000107 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Rflna refilin A involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1923816 (PMID:24436304)		 GO_Central
RGD		 PMID:24436304 GO_REF:0000033 NCBI chr12:31,633,360...31,642,313
Ensembl chr12:31,633,361...31,642,317 		JBrowse link
G Rflnb refilin B involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:1920371 (PMID:24436304)		 GO_Central
RGD		 PMID:24436304 GO_REF:0000033 NCBI chr10:60,893,693...60,899,970
Ensembl chr10:60,893,713...60,899,976 		JBrowse link
negative regulation of chondrocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 involved_in ISO (PMID:22247065) RGD PMID:22247065 NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629 		JBrowse link
G Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 involved_in ISO (PMID:22247065) RGD PMID:22247065 NCBI chr 8:90,704,727...90,744,333
Ensembl chr 8:90,704,727...90,744,328 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:17481601)		 Ensembl
RGD		 PMID:17481601 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Ccn4 cellular communication network factor 4 involved_in IEA
ISO		 GO_REF:0000107
(MGI:6294593|PMID:15331410)		 Ensembl
RGD		 PMID:15331410 GO_REF:0000107 MGI:6294593 NCBI chr 7:98,645,238...98,677,253
Ensembl chr 7:98,645,182...98,677,248 		JBrowse link
G Chadl chondroadherin-like involved_in ISO (MGI:5617405|PMID:25451920) RGD PMID:25451920 MGI:5617405 NCBI chr 7:113,205,323...113,218,678
Ensembl chr 7:113,210,748...113,217,272 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2148591|MGI:2148594|MGI:2446084|MGI:2450929 (PMID:15866163), (PMID:16818445)		 Ensembl
RGD		 PMID:15866163 PMID:16818445 GO_REF:0000107 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 involved_in ISO
IEA
ISS		 (PMID:20005202)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20005202 GO_REF:0000024 GO_REF:0000107 NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018 		JBrowse link
G Gdf5 growth differentiation factor 5 involved_in ISO (PMID:21976273) RGD PMID:21976273 NCBI chr 3:144,454,316...144,458,508
Ensembl chr 3:144,454,338...144,458,612 		JBrowse link
G Gli2 GLI family zinc finger 2 acts_upstream_of_or_within ISO MGI:1857509 (PMID:17328886) RGD PMID:17328886 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 acts_upstream_of_or_within ISO MGI:96533 (PMID:16284117) RGD PMID:16284117 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:10556075) RGD PMID:10556075 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Ihh Indian hedgehog signaling molecule acts_upstream_of_or_within ISO MGI:1934258 (PMID:16284117) RGD PMID:16284117 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 acts_upstream_of_or_within ISO MGI:2180017 (PMID:11790802) RGD PMID:11790802 NCBI chr 1:203,029,412...203,045,975
Ensembl chr 1:203,029,877...203,045,975 		JBrowse link
G Mkx mohawk homeobox IMP RGD PMID:27370800 RGD:40924660 NCBI chr17:55,077,073...55,156,877
Ensembl chr17:55,077,540...55,156,124 		JBrowse link
G Nkx3-2 NK3 homeobox 2 involved_in ISO (MGI:3617032|PMID:16421188) RGD PMID:16421188 MGI:3617032 NCBI chr14:69,183,795...69,186,182
Ensembl chr14:69,183,820...69,186,061 		JBrowse link
G Pth parathyroid hormone involved_in IMP PMID:11604398 CAFA PMID:11604398 RGD:12793028 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Pthlh parathyroid hormone-like hormone acts_upstream_of_or_within ISO (PMID:90087)
MGI:2154515|MGI:95728 (PMID:17328886), (PMID:8895385)		 RGD PMID:90087 PMID:8895385 PMID:17328886 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:6414736|PMID:29644115)		 UniProt
Ensembl
RGD		 PMID:29644115 GO_REF:0000024 GO_REF:0000107 MGI:6414736 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rarb retinoic acid receptor, beta acts_upstream_of_or_within ISO (PMID:10684250) RGD PMID:10684250 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rarg retinoic acid receptor, gamma acts_upstream_of_or_within ISO (PMID:10684250) RGD PMID:10684250 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:19756381) RGD PMID:19756381 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:2158693 (PMID:11371614)		 UniProt
RGD		 PMID:11371614 GO_REF:0000024 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO
IEA		 (MGI:3848261|PMID:19494318)
GO_REF:0000107		 RGD
Ensembl		 PMID:19494318 GO_REF:0000107 MGI:3848261 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Wnt9a Wnt family member 9A acts_upstream_of_or_within ISO MGI:3701350|MGI:88276 (PMID:16818445) RGD PMID:16818445 NCBI chr10:44,094,140...44,121,134
Ensembl chr10:44,094,140...44,121,133 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    negative regulation of biological process 5810
      negative regulation of multicellular organismal process 1363
        negative regulation of cartilage development 34
          negative regulation of chondrocyte differentiation + 26
Path 2
Term Annotations click to browse term
  biological_process 20115
    developmental process 7008
      anatomical structure development 6530
        multicellular organism development 5268
          system development 4550
            skeletal system development 577
              cartilage development 236
                regulation of cartilage development 75
                  negative regulation of cartilage development 34
                    negative regulation of chondrocyte differentiation + 26
paths to the root