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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of cartilage development
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Accession:GO:0061036 term browser browse the term
Definition:Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.

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positive regulation of cartilage development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp1 bone morphogenetic protein 1 acts_upstream_of_or_within ISO (PMID:3201241) MGI PMID:3201241 NCBI chrNW_004955403:45,660,591...45,693,724
Ensembl chrNW_004955403:45,660,588...45,693,724 		JBrowse link
G Bmp10 bone morphogenetic protein 10 involved_in ISO (MGI:5621263|PMID:19956691) UniProt PMID:19956691 MGI:5621263 NCBI chrNW_004955424:16,124,526...16,130,723
Ensembl chrNW_004955424:16,124,464...16,134,012 		JBrowse link
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within ISO (PMID:3201241)
(PMID:10684250)		 MGI PMID:3201241 PMID:10684250 NCBI chrNW_004955415:17,048,374...17,058,172
Ensembl chrNW_004955415:17,048,030...17,060,181 		JBrowse link
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within ISO (PMID:3201241) MGI PMID:3201241 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303 		JBrowse link
G Ccn1 cellular communication network factor 1 acts_upstream_of_or_within ISO (PMID:9441684) MGI PMID:9441684 NCBI chrNW_004955423:8,416,498...8,419,029
Ensembl chrNW_004955423:8,413,725...8,419,166 		JBrowse link
G Gdf2 growth differentiation factor 2 involved_in ISO (MGI:5621263|PMID:19956691) UniProt PMID:19956691 MGI:5621263 NCBI chrNW_004955556:2,204,841...2,210,335
Ensembl chrNW_004955556:2,205,071...2,209,055 		JBrowse link
G Mdk midkine involved_in ISO (MGI:5693192|PMID:25551381) UniProt PMID:25551381 MGI:5693192 NCBI chrNW_004955422:1,655,351...1,657,026
Ensembl chrNW_004955422:1,655,358...1,657,044 		JBrowse link
G Scx scleraxis bHLH transcription factor involved_in ISO (MGI:1343990|PMID:10477299) UniProt PMID:10477299 MGI:1343990 NCBI chrNW_004955454:2,886,981...2,888,829
Ensembl chrNW_004955454:2,886,981...2,888,829 		JBrowse link
G Smad1 SMAD family member 1 acts_upstream_of_or_within ISO (PMID:19251704) MGI PMID:19251704 NCBI chrNW_004955428:1,357,398...1,429,521
Ensembl chrNW_004955428:1,361,085...1,429,948 		JBrowse link
G Sox5 SRY-box transcription factor 5 involved_in ISO (PMID:21401405) UniProt PMID:21401405 NCBI chrNW_004955413:18,831,931...19,676,371
Ensembl chrNW_004955413:18,831,931...19,204,217 		JBrowse link
G Sox6 SRY-box transcription factor 6 involved_in ISO (PMID:21401405) UniProt PMID:21401405 NCBI chrNW_004955414:30,965,626...31,532,473
Ensembl chrNW_004955414:30,971,920...31,335,263 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in
acts_upstream_of_or_within		 ISO (PMID:21401405), (PMID:29503843)
(PMID:19047045)		 CACAO
MGI		 PMID:19047045 PMID:21401405 PMID:29503843 NCBI chrNW_004955478:941,684...945,563
Ensembl chrNW_004955478:940,177...945,563 		JBrowse link
G Wnt5a Wnt family member 5A acts_upstream_of_or_within ISO (PMID:18991062) MGI PMID:18991062 NCBI chrNW_004955430:5,304,817...5,325,684
Ensembl chrNW_004955430:5,304,745...5,325,684 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 involved_in ISO (PMID:21547890) UniProt PMID:21547890 NCBI chrNW_004955412:15,668,332...15,845,384
Ensembl chrNW_004955412:15,668,332...15,845,372 		JBrowse link
positive regulation of chondrocyte development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxa11 homeobox A11 acts_upstream_of_or_within ISO (PMID:14668414) MGI PMID:14668414 NCBI chrNW_004955410:28,875,780...28,879,643
Ensembl chrNW_004955410:28,877,055...28,879,465 		JBrowse link
G Hoxd11 homeobox D11 acts_upstream_of_or_within ISO (PMID:14668414) MGI PMID:14668414 NCBI chrNW_004955403:20,541,870...20,556,574 JBrowse link
positive regulation of chondrocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 ISO RGD PMID:23077084 RGD:7242190 NCBI chrNW_004955465:6,053,600...6,201,254
Ensembl chrNW_004955465:6,054,931...6,200,377 		JBrowse link
G Fgf18 fibroblast growth factor 18 acts_upstream_of_or_within ISO (PMID:15781473) MGI PMID:15781473 NCBI chrNW_004955408:24,225,459...24,260,057
Ensembl chrNW_004955408:24,225,459...24,260,092 		JBrowse link
G Gdf5 growth differentiation factor 5 involved_in
acts_upstream_of_or_within		 ISO (PMID:21976273), (PMID:24098149)
(PMID:9885252)
(PMID:18363966)		 UniProt
MGI		 PMID:9885252 PMID:18363966 PMID:21976273 PMID:24098149 NCBI chrNW_004955422:25,992,081...25,997,122
Ensembl chrNW_004955422:25,992,081...25,997,122 		JBrowse link
G Gdf6 growth differentiation factor 6 involved_in ISO (PMID:26643732) UniProt PMID:26643732 NCBI chrNW_004955417:12,152,448...12,169,173
Ensembl chrNW_004955417:12,152,448...12,169,362 		JBrowse link
G Gli3 GLI family zinc finger 3 acts_upstream_of_or_within ISO (PMID:17328886) MGI PMID:17328886 NCBI chrNW_004955460:1,528,457...1,805,584
Ensembl chrNW_004955460:1,528,412...1,805,918 		JBrowse link
G Hoxa11 homeobox A11 acts_upstream_of_or_within ISO (PMID:14668414) MGI PMID:14668414 NCBI chrNW_004955410:28,875,780...28,879,643
Ensembl chrNW_004955410:28,877,055...28,879,465 		JBrowse link
G Hoxd11 homeobox D11 acts_upstream_of_or_within ISO (PMID:14668414) MGI PMID:14668414 NCBI chrNW_004955403:20,541,870...20,556,574 JBrowse link
G Loxl2 lysyl oxidase like 2 involved_in ISO (MGI:5320274|PMID:21071451) UniProt PMID:21071451 MGI:5320274 NCBI chrNW_004955403:46,503,226...46,583,807
Ensembl chrNW_004955403:46,504,440...46,584,016 		JBrowse link
G Mustn1 musculoskeletal, embryonic nuclear protein 1 acts_upstream_of_or_within ISO (PMID:19410023) MGI PMID:19410023 NCBI chrNW_004955430:2,790,090...2,793,880
Ensembl chrNW_004955430:2,790,090...2,793,880 		JBrowse link
G Pkdcc protein kinase domain containing, cytoplasmic involved_in ISO (MGI:3813934|PMID:19097194), (MGI:4438146|PMID:19465597) UniProt PMID:19097194 PMID:19465597 MGI:3813934 MGI:4438146 NCBI chrNW_004955441:9,462,530...9,471,446
Ensembl chrNW_004955441:9,462,530...9,471,446 		JBrowse link
G Por P450 (cytochrome) oxidoreductase ISO RGD PMID:19264869 RGD:2316785 NCBI chrNW_004955456:14,698,589...14,748,520
Ensembl chrNW_004955456:14,698,589...14,748,520 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 ISO RGD PMID:15466490 RGD:150429792 NCBI chrNW_004955433:5,286,594...5,387,571
Ensembl chrNW_004955433:5,286,153...5,491,924 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO RGD PMID:17884819 RGD:2298851 NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516 		JBrowse link
G Runx2 RUNX family transcription factor 2 acts_upstream_of_or_within ISO (PMID:10072783) MGI PMID:10072783 NCBI chrNW_004955437:10,598,145...10,885,858
Ensembl chrNW_004955437:10,598,145...10,800,560 		JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (MGI:5285145|PMID:21035443) UniProt PMID:21035443 MGI:5285145 NCBI chrNW_004955450:8,747,651...8,842,003
Ensembl chrNW_004955450:8,747,651...8,842,136 		JBrowse link
G Sox5 SRY-box transcription factor 5 involved_in ISO (PMID:21401405)
(MGI:5285147|PMID:20940257)		 UniProt PMID:20940257 PMID:21401405 MGI:5285147 NCBI chrNW_004955413:18,831,931...19,676,371
Ensembl chrNW_004955413:18,831,931...19,204,217 		JBrowse link
G Sox6 SRY-box transcription factor 6 involved_in ISO (PMID:21401405)
(MGI:5285147|PMID:20940257)		 UniProt PMID:20940257 PMID:21401405 MGI:5285147 NCBI chrNW_004955414:30,965,626...31,532,473
Ensembl chrNW_004955414:30,971,920...31,335,263 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in ISO (PMID:21401405)
(MGI:4950303|PMID:21367821)
(MGI:5285147|PMID:20940257)
(PMID:20676705)		 UniProt PMID:20676705 PMID:20940257 PMID:21367821 PMID:21401405 MGI:4950303 MGI:5285147 NCBI chrNW_004955478:941,684...945,563
Ensembl chrNW_004955478:940,177...945,563 		JBrowse link
G Thrb thyroid hormone receptor beta ISO RGD PMID:15647824 RGD:1601663 NCBI chrNW_004955430:15,992,146...16,322,696
Ensembl chrNW_004955430:15,992,146...16,323,238 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 involved_in ISO (PMID:21547890) UniProt PMID:21547890 NCBI chrNW_004955412:15,668,332...15,845,384
Ensembl chrNW_004955412:15,668,332...15,845,372 		JBrowse link
G Znf219 zinc finger protein 219 involved_in ISO (MGI:5285147|PMID:20940257) UniProt PMID:20940257 MGI:5285147 NCBI chrNW_004955550:1,854,330...1,861,836 JBrowse link
positive regulation of chondrocyte hypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad7 SMAD family member 7 involved_in ISO (MGI:6377914|PMID:29503843) CACAO PMID:29503843 MGI:6377914 NCBI chrNW_004955402:34,028,184...34,058,949
Ensembl chrNW_004955402:34,028,063...34,058,291 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    positive regulation of biological process 5597
      positive regulation of multicellular organismal process 1631
        positive regulation of cartilage development 32
          positive regulation of chondrocyte differentiation + 22
Path 2
Term Annotations click to browse term
  biological_process 12346
    developmental process 5853
      anatomical structure development 5540
        multicellular organism development 4550
          system development 3953
            skeletal system development 534
              cartilage development 220
                regulation of cartilage development 73
                  positive regulation of cartilage development 32
                    positive regulation of chondrocyte differentiation + 22
paths to the root