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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of miRNA-mediated gene silencing
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Accession:GO:0060964 term browser browse the term
Definition:A process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs).
Synonyms:exact_synonym: regulation of gene silencing by miRNA;   regulation of gene silencing by microRNA


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regulation of miRNA-mediated gene silencing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIN28A lin-28 homolog A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19898466) Ensembl
MGI		 PMID:19898466 GO_REF:0000107 NCBI chr 1:26,410,817...26,429,728
Ensembl chr 1:26,410,817...26,429,728 		JBrowse link
G MAEL maelstrom spermatogenic transposon silencer involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:166,975,582...167,022,214
Ensembl chr 1:166,975,582...167,022,214 		JBrowse link
G MIR154 microRNA 154 acts_upstream_of_or_within ISO (PMID:25959411) MGI PMID:25959411 NCBI chr14:101,059,755...101,059,838
Ensembl chr14:101,059,755...101,059,838 		JBrowse link
G MIRLET7A2 microRNA let-7a-2 acts_upstream_of_or_within ISO (PMID:19898466) MGI PMID:19898466 NCBI chr11:122,146,522...122,146,593
Ensembl chr11:122,146,522...122,146,593 		JBrowse link
G PUM1 pumilio RNA binding family member 1 involved_in TAS (PMID:18776931) UniProt PMID:18776931 NCBI chr 1:30,931,506...31,065,717
Ensembl chr 1:30,931,506...31,065,991 		JBrowse link
G PUM2 pumilio RNA binding family member 2 involved_in TAS (PMID:18776931) UniProt PMID:18776931 NCBI chr 2:20,248,691...20,352,253
Ensembl chr 2:20,248,691...20,352,234 		JBrowse link
G TNRC6C trinucleotide repeat containing adaptor 6C acts_upstream_of_or_within ISO (PMID:22187428) MGI PMID:22187428 NCBI chr17:77,957,557...78,108,835
Ensembl chr17:77,958,703...78,108,822 		JBrowse link
G TRIM71 tripartite motif containing 71 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19898466) Ensembl
MGI		 PMID:19898466 GO_REF:0000107 NCBI chr 3:32,817,997...32,897,824
Ensembl chr 3:32,817,997...32,897,824 		JBrowse link
negative regulation of miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNF1A HNF1 homeobox A involved_in ISO
IEA		 RGD
Ensembl		 PMID:23674172 GO_REF:0000107 RGD:150540303 NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21522133) Ensembl
MGI		 PMID:21522133 GO_REF:0000107 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G ZC3H10 zinc finger CCCH-type containing 10 involved_in IDA (PMID:28431233) UniProt PMID:28431233 NCBI chr12:56,118,266...56,127,514
Ensembl chr12:56,118,260...56,127,514 		JBrowse link
G ZMPSTE24 zinc metallopeptidase STE24 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21522133) Ensembl
MGI		 PMID:21522133 GO_REF:0000107 NCBI chr 1:40,258,236...40,294,180
Ensembl chr 1:40,258,041...40,294,180 		JBrowse link
negative regulation of miRNA-mediated gene silencing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DND1 DND microRNA-mediated repression inhibitor 1 involved_in IDA
IEA
IBA		 (PMID:18155131) UniProt
TreeGrafter
GO_Central		 PMID:18155131 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:140,670,794...140,673,576
Ensembl chr 5:140,670,794...140,673,576 		JBrowse link
G ELAVL1 ELAV like RNA binding protein 1 involved_in IMP (PMID:26595526) UniProt PMID:26595526 NCBI chr19:7,958,573...8,005,641
Ensembl chr19:7,958,573...8,005,659 		JBrowse link
G FMR1 fragile X messenger ribonucleoprotein 1 involved_in IMP (PMID:25464849) UniProt PMID:25464849 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,919...147,951,125 		JBrowse link
negative regulation of pre-miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCDIN3D BCDIN3 domain containing RNA methyltransferase involved_in IDA
IBA
IEA		 (PMID:23063121) UniProt
GO_Central
TreeGrafter		 PMID:23063121 GO_REF:0000033 GO_REF:0000118 NCBI chr12:49,836,043...49,843,106
Ensembl chr12:49,836,043...49,843,106 		JBrowse link
G HOXB-AS3 HOXB cluster antisense RNA 3 involved_in IDA (PMID:28985503) UniProt PMID:28985503 NCBI chr17:48,590,420...48,606,414
Ensembl chr17:48,549,630...48,606,414 		JBrowse link
G LIN28A lin-28 homolog A involved_in IDA (PMID:21247876) UniProt PMID:21247876 NCBI chr 1:26,410,817...26,429,728
Ensembl chr 1:26,410,817...26,429,728 		JBrowse link
G LIN28B lin-28 homolog B involved_in IDA (PMID:18951094) CACAO PMID:18951094 NCBI chr 6:104,937,026...105,083,332
Ensembl chr 6:104,936,616...105,083,332 		JBrowse link
negative regulation of primary miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 acts_upstream_of IGI (PMID:31507089) ARUK-UCL PMID:31507089 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G LIN28B lin-28 homolog B involved_in IDA (PMID:18951094) CACAO PMID:18951094 NCBI chr 6:104,937,026...105,083,332
Ensembl chr 6:104,936,616...105,083,332 		JBrowse link
G MECP2 methyl-CpG binding protein 2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:24636259 GO_REF:0000107 RGD:12789709 NCBI chr  X:154,021,573...154,097,717
Ensembl chr  X:154,021,573...154,137,103 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IMP (PMID:31507089) ARUK-UCL PMID:31507089 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
positive regulation of miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RIPK1 receptor interacting serine/threonine kinase 1 acts_upstream_of IDA (PMID:26020802) ARUK-UCL PMID:26020802 NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187 		JBrowse link
positive regulation of miRNA-mediated gene silencing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AJUBA ajuba LIM protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:22,971,177...22,982,551
Ensembl chr14:22,971,177...22,982,551 		JBrowse link
G FMR1 fragile X messenger ribonucleoprotein 1 involved_in IDA (PMID:17057366) UniProt PMID:17057366 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,919...147,951,125 		JBrowse link
G FXR1 FMR1 autosomal homolog 1 involved_in IDA (PMID:17057366) UniProt PMID:17057366 NCBI chr 3:180,912,670...180,982,753
Ensembl chr 3:180,868,141...180,982,753 		JBrowse link
G LIMD1 LIM domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:45,594,751...45,686,341
Ensembl chr 3:45,555,394...45,686,341 		JBrowse link
G PUM1 pumilio RNA binding family member 1 involved_in IDA (PMID:20818387), (PMID:22345517) UniProt PMID:20818387 PMID:22345517 NCBI chr 1:30,931,506...31,065,717
Ensembl chr 1:30,931,506...31,065,991 		JBrowse link
G PUM2 pumilio RNA binding family member 2 involved_in IMP (PMID:22345517) UniProt PMID:22345517 NCBI chr 2:20,248,691...20,352,253
Ensembl chr 2:20,248,691...20,352,234 		JBrowse link
G TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 involved_in IGI (PMID:33203680) FlyBase PMID:33203680 NCBI chr10:119,573,465...119,596,964
Ensembl chr10:119,571,802...119,597,029 		JBrowse link
G TRIM71 tripartite motif containing 71 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19898466) Ensembl
MGI		 PMID:19898466 GO_REF:0000107 NCBI chr 3:32,817,997...32,897,824
Ensembl chr 3:32,817,997...32,897,824 		JBrowse link
G WTIP WT1 interacting protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:34,481,758...34,512,304
Ensembl chr19:34,481,758...34,512,304 		JBrowse link
G ZFP36 ZFP36 ring finger protein involved_in IMP (PMID:15766526) UniProt PMID:15766526 NCBI chr19:39,406,847...39,409,407
Ensembl chr19:39,406,847...39,409,412 		JBrowse link
positive regulation of pre-miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGCR8 DGCR8 microprocessor complex subunit involved_in IDA (PMID:15574589), (PMID:32926445) UniProt PMID:15574589 PMID:32926445 NCBI chr22:20,080,241...20,111,872
Ensembl chr22:20,080,221...20,111,877 		JBrowse link
G TRUB1 TruB pseudouridine synthase family member 1 involved_in IDA (PMID:32926445) UniProt PMID:32926445 NCBI chr10:114,938,195...114,977,676
Ensembl chr10:114,938,195...114,977,676 		JBrowse link
positive regulation of primary miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IDA (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761 		JBrowse link
G PRPF6 pre-mRNA processing factor 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:63,981,132...64,033,100
Ensembl chr20:63,981,132...64,033,100 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in IDA (PMID:18548003) BHF-UCL PMID:18548003 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    metabolic process 12509
      regulation of metabolic process 7344
        regulation of macromolecule metabolic process 6746
          regulation of macromolecule biosynthetic process 5939
            regulation of gene expression 5819
              regulation of post-transcriptional gene silencing 36
                regulation of post-transcriptional gene silencing by regulatory ncRNA 35
                  regulation of miRNA-mediated gene silencing 33
                    negative regulation of miRNA-mediated gene silencing + 14
                    positive regulation of miRNA-mediated gene silencing + 16
Path 2
Term Annotations click to browse term
  biological_process 19770
    biological regulation 13405
      regulation of biological process 13030
        regulation of metabolic process 7344
          regulation of cellular metabolic process 6887
            regulation of cellular biosynthetic process 6085
              regulation of macromolecule biosynthetic process 5939
                negative regulation of macromolecule biosynthetic process 2951
                  negative regulation of gene expression 1802
                    regulatory ncRNA-mediated gene silencing 733
                      regulatory ncRNA-mediated post-transcriptional gene silencing 662
                        regulation of post-transcriptional gene silencing by regulatory ncRNA 35
                          regulation of miRNA-mediated gene silencing 33
                            negative regulation of miRNA-mediated gene silencing + 14
                            positive regulation of miRNA-mediated gene silencing + 16
paths to the root