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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac fibroblast cell differentiation
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Accession:GO:0060935 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules.


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epicardium-derived cardiac fibroblast cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr3 transforming growth factor beta receptor 3 involved_in ISO (MGI:3818140|PMID:17704211) BHF-UCL PMID:17704211 MGI:3818140 NCBI chrNW_004936537:7,154,125...7,340,218 JBrowse link
epithelial to mesenchymal transition involved in cardiac fibroblast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd4 programmed cell death 4 involved_in ISO PMID:23441172 BHF-UCL PMID:23441172 RGD:10400865 NCBI chrNW_004936486:1,684,167...1,705,387 JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 involved_in ISO PMID:23441172 BHF-UCL PMID:23441172 RGD:10400865 NCBI chrNW_004936662:2,241,928...2,245,616 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12130
    developmental process 5711
      cellular developmental process 3716
        cell differentiation 3653
          cardiocyte differentiation 174
            cardiac fibroblast cell differentiation 3
              cardiac fibroblast cell development + 3
              cardiac fibroblast cell fate commitment + 0
              epicardium-derived cardiac fibroblast cell differentiation + 3
              neural crest-derived cardiac fibroblast cell differentiation + 0
Path 2
Term Annotations click to browse term
  biological_process 12130
    developmental process 5711
      anatomical structure development 5339
        multicellular organism development 4889
          system development 4606
            circulatory system development 1115
              heart development 637
                cardiocyte differentiation 174
                  cardiac fibroblast cell differentiation 3
                    cardiac fibroblast cell development + 3
                    cardiac fibroblast cell fate commitment + 0
                    epicardium-derived cardiac fibroblast cell differentiation + 3
                    neural crest-derived cardiac fibroblast cell differentiation + 0
paths to the root