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ONTOLOGY REPORT - ANNOTATIONS


Term:heart formation
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Accession:GO:0060914 term browser browse the term
Definition:The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.
Synonyms:related_synonym: cardiogenesis



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heart formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO MGI:2158343 (MGI:3702797|PMID:16943278) RGD PMID:16943278 MGI:3702797 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
JBrowse link
G Ift88 intraflagellar transport 88 acts_upstream_of_or_within ISO MGI:1859153 (MGI:4361064|PMID:19654211) RGD PMID:19654211 MGI:4361064 NCBI chr15:31,573,325...31,666,068
Ensembl chr15:31,573,376...31,672,147
JBrowse link
G Lemd2 LEM domain nuclear envelope protein 2 involved_in ISO (MGI:5640886|PMID:25790465) RGD PMID:25790465 MGI:5640886 NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626
JBrowse link
BMP signaling pathway involved in heart induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO
ISS
(PMID:19736317)
GO_REF:0000024
RGD
UniProt
PMID:19736317 GO_REF:0000024 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in ISO
IEA
ISS
(PMID:20702560)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20702560 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
cardioblast anterior-lateral migration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 acts_upstream_of_or_within ISO (PMID:18297060) RGD PMID:18297060 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
cardioblast migration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:2182080 (MGI:1339460|PMID:10393122) RGD PMID:10393122 MGI:1339460 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
cardioblast migration to the midline involved in heart field formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:1339460|PMID:10393122) RGD PMID:10393122 MGI:1339460 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
heart field specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:5907444|PMID:26295701) RGD PMID:26295701 MGI:5907444 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357
JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link
neural crest cell migration involved in heart formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folr1 folate receptor alpha involved_in ISO (MGI:3721767|PMID:17286298) RGD PMID:17286298 MGI:3721767 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667
JBrowse link
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 acts_upstream_of_or_within ISO (MGI:4438134|PMID:19620969) RGD PMID:19620969 MGI:4438134 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
positive regulation of cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase involved_in ISO (PMID:21474815) RGD PMID:21474815 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
G Wnt11 Wnt family member 11 involved_in ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294
JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P48615 (MGI:5424267|PMID:22569553)
Ensembl
RGD
PMID:22569553 GO_REF:0000107 MGI:5424267 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
positive regulation of Notch signaling pathway involved in heart induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata5 GATA binding protein 5 involved_in ISO (MGI:5286818|PMID:21633169) RGD PMID:21633169 MGI:5286818 NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO (MGI:5913048|PMID:25691540) RGD PMID:25691540 MGI:5913048 NCBI chr11:10,580,863...11,621,672
Ensembl chr11:10,580,908...11,620,203
JBrowse link
G Robo2 roundabout guidance receptor 2 involved_in ISO (MGI:5913048|PMID:25691540) RGD PMID:25691540 MGI:5913048 NCBI chr11:12,528,949...14,096,726
Ensembl chr11:12,528,951...13,041,536
JBrowse link
positive regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 acts_upstream_of_or_within ISO MGI:102780 (MGI:5002778|PMID:21364285) RGD PMID:21364285 MGI:5002778 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
JBrowse link
G Gng5 G protein subunit gamma 5 acts_upstream_of_or_within ISO (MGI:5604689|PMID:24599258) RGD PMID:24599258 MGI:5604689 NCBI chr 2:235,394,680...235,403,177 JBrowse link
G Six1 SIX homeobox 1 acts_upstream_of_or_within ISO MGI:109344 (MGI:5002778|PMID:21364285) RGD PMID:21364285 MGI:5002778 NCBI chr 6:91,746,739...91,751,975
Ensembl chr 6:91,746,739...91,751,975
JBrowse link
G Tbx1 T-box transcription factor 1 acts_upstream_of_or_within ISO (MGI:4943633|PMID:19745164) RGD PMID:19745164 MGI:4943633 NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380
JBrowse link
G Tbx5 T-box transcription factor 5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2387851 (MGI:5437816|PMID:22898775)
Ensembl
RGD
PMID:22898775 GO_REF:0000107 MGI:5437816 NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885
JBrowse link
primary heart field specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO
GO_REF:0000024
(MGI:3830899|PMID:16680724)
UniProt
RGD
PMID:16680724 GO_REF:0000024 MGI:3830899 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Wnt11 Wnt family member 11 involved_in ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294
JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P48615 (MGI:5424267|PMID:22569553)
Ensembl
RGD
PMID:22569553 GO_REF:0000107 MGI:5424267 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
regulation of cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 IMP RGD PMID:18824567 RGD:2325311 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
regulation of heart induction by regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:4438134|PMID:19620969)
Ensembl
RGD
PMID:19620969 GO_REF:0000107 MGI:4438134 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:4413411|PMID:19008477)
Ensembl
RGD
PMID:19008477 GO_REF:0000107 MGI:4413411 NCBI chr16:32,917,826...32,919,880
Ensembl chr16:32,917,823...32,919,891
JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:4354447|PMID:19609448)
Ensembl
RGD
PMID:19609448 GO_REF:0000107 MGI:4354447 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Isl1 ISL LIM homeobox 1 acts_upstream_of_or_within ISO MGI:2447758 (MGI:4438134|PMID:19620969) RGD PMID:19620969 MGI:4438134 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584
JBrowse link
secondary heart field specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axin2 axin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:96522 (MGI:5432296|PMID:22711842)
Ensembl
RGD
PMID:22711842 GO_REF:0000107 MGI:5432296 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:20702560)
Ensembl
UniProt
RGD
PMID:20702560 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Foxh1 forkhead box H1 involved_in ISO (MGI:3055632|PMID:15363409) RGD PMID:15363409 MGI:3055632 NCBI chr 7:108,387,969...108,391,566
Ensembl chr 7:108,387,969...108,390,049
JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in ISO (PMID:20520780) RGD PMID:20520780 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584
JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5770180|PMID:26822476)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:26822476 GO_REF:0000024 GO_REF:0000107 MGI:5770180 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO
GO_REF:0000024
(MGI:3578591|PMID:15890826)
UniProt
RGD
PMID:15890826 GO_REF:0000024 MGI:3578591 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within ISO MGI:1270862|MGI:3583755 (MGI:5432296|PMID:22711842) RGD PMID:22711842 MGI:5432296 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
G Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 acts_upstream_of_or_within ISO MGI:2148567 (MGI:3828346|PMID:17519332) RGD PMID:17519332 MGI:3828346 NCBI chr 4:10,548,693...10,580,334
Ensembl chr 4:10,548,751...10,580,326
JBrowse link
G Wnt11 Wnt family member 11 involved_in ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294
JBrowse link
G Wnt5a Wnt family member 5A involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P48615 (MGI:5424267|PMID:22569553)
Ensembl
RGD
PMID:22569553 GO_REF:0000107 MGI:5424267 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mks1 MKS transition zone complex subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:4821832 (MGI:5811184|PMID:27340223)
Ensembl
RGD
PMID:27340223 GO_REF:0000107 MGI:5811184 NCBI chr10:72,655,921...72,667,007
Ensembl chr10:72,655,921...72,666,655
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure formation involved in morphogenesis 1239
        animal organ formation 76
          heart formation 34
            cardioblast proliferation + 12
            cell migration involved in heart formation + 2
            heart field specification + 19
Path 2
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure development 6306
        multicellular organism development 5727
          system development 5373
            animal organ development 4130
              heart development 698
                heart morphogenesis 285
                  heart formation 34
                    cardioblast proliferation + 12
                    cell migration involved in heart formation + 2
                    heart field specification + 19
paths to the root