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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac cell fate commitment
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Accession:GO:0060911 term browser browse the term
Definition:The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system.
Synonyms:exact_synonym: cardiocyte cell fate commitment


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atrioventricular node cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-5 NK2 homeobox 5 IEA
ISO
GO_REF:0000107
MGI:3042511 (MGI:3040116|PMID:15109497)
Ensembl
RGD
PMID:15109497 GO_REF:0000107, MGI:3040116 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Wnt8a Wnt family member 8A ISO (PMID:20559569) RGD PMID:20559569 NCBI chr18:27,331,236...27,336,829
Ensembl chr18:27,331,236...27,336,829
JBrowse link
cardiac cell fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Isl1 ISL LIM homeobox 1 ISO (PMID:19571884)
(MGI:4438134|PMID:19620969)
RGD PMID:19571884, PMID:19620969 MGI:4438134 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Sox17 SRY-box transcription factor 17 ISO (PMID:19736317) RGD PMID:19736317 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
cardiac cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tenm4 teneurin transmembrane protein 4 ISO MGI:3655239 (MGI:5429684|PMID:17350578) RGD PMID:17350578 MGI:5429684 NCBI chr 1:161,183,858...161,885,094
Ensembl chr 1:161,401,527...161,880,923
JBrowse link
cardiac muscle cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 ISO
IEA
(PMID:19506109)
GO_REF:0000107
RGD
Ensembl
PMID:19506109 GO_REF:0000107 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
G RGD1311744 similar to RIKEN cDNA 5830475I06 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:43,315,104...43,336,357
Ensembl chr 8:43,315,592...43,336,304
JBrowse link
G Tbx3 T-box transcription factor 3 ISO MGI:3710254 (MGI:3847383|PMID:18467625) RGD PMID:18467625 MGI:3847383 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
G Wnt3a Wnt family member 3A ISO MGI:2143322 (MGI:5295932|PMID:21554246) RGD PMID:21554246 MGI:5295932 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Wt1 WT1 transcription factor ISO (MGI:5285454|PMID:21654746) RGD PMID:21654746 MGI:5285454 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link
endocardial cushion cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 ISO
IEA
(PMID:19506109)
GO_REF:0000107
RGD
Ensembl
PMID:19506109 GO_REF:0000107 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A ISO (PMID:19736317) RGD PMID:19736317 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO MGI:3583755 (MGI:5432296|PMID:22711842) RGD PMID:22711842 MGI:5432296 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
regulation of cardiac cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox17 SRY-box transcription factor 17 ISO (MGI:3703823|PMID:17360443) RGD PMID:17360443 MGI:3703823 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cellular developmental process 4457
        cell fate commitment 282
          cardiac cell fate commitment 14
            His-Purkinje system cell fate commitment 0
            cardiac cell fate determination + 4
            cardiac cell fate specification + 3
            cardiac fibroblast cell fate commitment + 0
            cardiac glial cell fate commitment + 0
            cardiac muscle cell fate commitment + 9
            cardiac neuron fate commitment 0
            cardiac vascular smooth muscle cell fate commitment + 0
            cardioblast cell fate commitment + 1
            dorsal vessel aortic cell fate commitment 0
            dorsal vessel heart proper cell fate commitment 0
            endocardial cell fate commitment + 1
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            animal organ development 4033
              heart development 687
                cardiocyte differentiation 180
                  cardiac cell fate commitment 14
                    His-Purkinje system cell fate commitment 0
                    cardiac cell fate determination + 4
                    cardiac cell fate specification + 3
                    cardiac fibroblast cell fate commitment + 0
                    cardiac glial cell fate commitment + 0
                    cardiac muscle cell fate commitment + 9
                    cardiac neuron fate commitment 0
                    cardiac vascular smooth muscle cell fate commitment + 0
                    cardioblast cell fate commitment + 1
                    dorsal vessel aortic cell fate commitment 0
                    dorsal vessel heart proper cell fate commitment 0
                    endocardial cell fate commitment + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.