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ONTOLOGY REPORT - ANNOTATIONS

Term:establishment of blood-brain barrier
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Accession:GO:0060856 term browser browse the term
Definition:Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
Synonyms:exact_synonym: establishment of BBB
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa


show annotations for term's descendants           Sort by:
establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO RGD PMID:22049154 RGD:8657330 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G BPGM bisphosphoglycerate mutase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:32966787) Ensembl
MGI		 PMID:32966787 GO_REF:0000107 NCBI chr 7:126,605,151...126,637,934
Ensembl chr 7:139,123,318...139,144,487 		JBrowse link
G CTNNB1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25083995) Ensembl
MGI		 PMID:25083995 GO_REF:0000107 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030 		JBrowse link
G FZD4 frizzled class receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30478038)
(PMID:23217714)		 Ensembl
MGI		 PMID:23217714 PMID:30478038 GO_REF:0000107 NCBI chr11:81,973,680...82,007,733
Ensembl chr11:85,611,989...85,616,065 		JBrowse link
G LRP5 LDL receptor related protein 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25083995) Ensembl
MGI		 PMID:25083995 GO_REF:0000107 NCBI chr11:63,396,511...63,534,471
Ensembl chr11:66,735,246...66,839,817 		JBrowse link
G LRP6 LDL receptor related protein 6 acts_upstream_of_or_within ISO (PMID:25083995) MGI PMID:25083995 NCBI chr12:12,121,411...12,288,590
Ensembl chr12:12,508,108...12,657,973 		JBrowse link
G LSR lipolysis stimulated lipoprotein receptor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:32,195,036...32,214,300
Ensembl chr19:40,932,180...40,951,448 		JBrowse link
G MFSD2A MFSD2 lysolipid transporter A, lysophospholipid NOT|involved_in ISO
IEA		 (MGI:5789479|PMID:27008858) ARUK-UCL
Ensembl		 PMID:27008858 GO_REF:0000107 MGI:5789479 NCBI chr 1:39,244,438...39,259,156
Ensembl chr 1:40,569,706...40,584,438 		JBrowse link
G NDP norrin cystine knot growth factor NDP involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23217714)
(PMID:30478038)		 Ensembl
MGI		 PMID:23217714 PMID:30478038 GO_REF:0000107 NCBI chr  X:36,399,868...36,424,953
Ensembl chr  X:44,224,161...44,249,067 		JBrowse link
G VPS4B vacuolar protein sorting 4 homolog B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28675177) Ensembl
MGI		 PMID:28675177 GO_REF:0000107 NCBI chr18:56,749,439...56,782,660
Ensembl chr18:60,060,285...60,095,109 		JBrowse link
G WNT7A Wnt family member 7A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30478038) Ensembl
MGI		 PMID:30478038 GO_REF:0000107 NCBI chr 3:13,733,487...13,797,189
Ensembl chr 3:14,077,839...14,138,386 		JBrowse link
establishment of endothelial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN3 claudin 3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 7:80,924,731...80,925,393 JBrowse link
G FOXP3 forkhead box P3 ISO RGD PMID:31027862 RGD:38549575 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
establishment of glial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DMD dystrophin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12673830) Ensembl
MGI		 PMID:12673830 GO_REF:0000107 NCBI chr  X:23,728,650...26,338,849
Ensembl chr  X:31,282,415...33,492,733 		JBrowse link
G MXRA8 matrix remodeling associated 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:109,071...117,378 JBrowse link
negative regulation of establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO RGD PMID:16056236 RGD:2317116 NCBI chr17:3,612,781...3,658,608
Ensembl chr17:3,609,952...3,637,579 		JBrowse link
G TTPA alpha tocopherol transfer protein involved_in ISO (MGI:4461120|PMID:19923370) BHF-UCL PMID:19923370 MGI:4461120 NCBI chr 8:59,591,592...59,619,658
Ensembl chr 8:61,266,954...61,293,699 		JBrowse link
regulation of establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRA2 adhesion G protein-coupled receptor A2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21421844) Ensembl
MGI		 PMID:21421844 GO_REF:0000107 NCBI chr 8:37,098,486...37,144,437
Ensembl chr 8:34,276,267...34,321,836 		JBrowse link
G RECK reversion inducing cysteine rich protein with kazal motifs involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:35,886,741...35,974,133
Ensembl chr 9:36,699,631...36,774,116 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    cellular process 15499
      cellular developmental process 4402
        cell development 3136
          establishment of blood-brain barrier 19
            establishment of endothelial blood-brain barrier 2
            establishment of glial blood-brain barrier 2
            negative regulation of establishment of blood-brain barrier 2
            positive regulation of establishment of blood-brain barrier 0
            regulation of establishment of blood-brain barrier + 4
Path 2
Term Annotations click to browse term
  biological_process 16440
    developmental process 6563
      anatomical structure development 6172
        multicellular organism development 4975
          system development 4324
            nervous system development 2702
              central nervous system development 1165
                establishment of blood-brain barrier 19
                  establishment of endothelial blood-brain barrier 2
                  establishment of glial blood-brain barrier 2
                  negative regulation of establishment of blood-brain barrier 2
                  positive regulation of establishment of blood-brain barrier 0
                  regulation of establishment of blood-brain barrier + 4
paths to the root