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ONTOLOGY REPORT - ANNOTATIONS

Term:establishment of blood-brain barrier
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Accession:GO:0060856 term browser browse the term
Definition:Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
Synonyms:exact_synonym: establishment of BBB
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa


show annotations for term's descendants           Sort by:
establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IMP RGD PMID:22049154 RGD:8657330 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 involved_in ISO (PMID:39087467) RGD PMID:39087467 NCBI chr 1:10,633,004...10,774,685
Ensembl chr 1:10,631,829...10,774,023 		JBrowse link
G Bpgm bisphosphoglycerate mutase acts_upstream_of_or_within ISO MGI:6506869 (PMID:32966787) RGD PMID:32966787 NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:64,106,804...64,135,627 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO
IEA 		(PMID:25083995)
GO_REF:0000107 		RGD
Ensembl		 PMID:25083995 GO_REF:0000107 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Fzd4 frizzled class receptor 4 acts_upstream_of_or_within ISO
IEA 		MGI:98961 (PMID:23217714), (PMID:30478038)
GO_REF:0000107 		RGD
Ensembl		 PMID:23217714 PMID:30478038 GO_REF:0000107 NCBI chr 1:152,692,507...152,701,372
Ensembl chr 1:152,692,507...152,701,372 		JBrowse link
G Lrp5 LDL receptor related protein 5 acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:2183279 (PMID:25083995)
GO_REF:0000117
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:25083995 GO_REF:0000107 GO_REF:0000117 NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:5299216 (PMID:25083995)
GO_REF:0000117 		RGD
UniProt		 PMID:25083995 GO_REF:0000117 NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716 		JBrowse link
G Lsr lipolysis stimulated lipoprotein receptor involved_in IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:25753034) 		GO_Central
Ensembl
RGD		 PMID:25753034 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:95,313,830...95,329,471
Ensembl chr 1:95,313,033...95,329,354 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid involved_in
NOT|involved_in 		ISO (PMID:24828040)
(PMID:27008858) 		RGD PMID:24828040 PMID:27008858 NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:140,510,953...140,525,916 		JBrowse link
G Ndp norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO
IEA 		MGI:98961 (PMID:23217714), (PMID:30478038)
GO_REF:0000107 		RGD
Ensembl		 PMID:23217714 PMID:30478038 GO_REF:0000107 NCBI chr  X:8,379,569...8,404,019
Ensembl chr  X:8,379,569...8,406,802 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B acts_upstream_of_or_within ISO (PMID:28675177) RGD PMID:28675177 NCBI chr13:23,421,758...23,446,848
Ensembl chr13:23,421,758...23,446,973 		JBrowse link
G Wnt7a Wnt family member 7A acts_upstream_of_or_within ISO
IEA 		MGI:102570|MGI:108520 (PMID:30478038)
GO_REF:0000107 		RGD
Ensembl		 PMID:30478038 GO_REF:0000107 NCBI chr 4:125,420,276...125,466,149
Ensembl chr 4:125,420,276...125,466,149 		JBrowse link
establishment of endothelial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, sub-family B member 1B IMP RGD PMID:16850390 RGD:1598561 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Cldn3 claudin 3 involved_in ISO
IEA 		(PMID:12734665)
GO_REF:0000107 		RGD
Ensembl		 PMID:12734665 GO_REF:0000107 NCBI chr12:27,345,075...27,346,547
Ensembl chr12:27,345,076...27,348,841 		JBrowse link
G Foxp3 forkhead box P3 IEP RGD PMID:31027862 RGD:38549575 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
establishment of glial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmd dystrophin acts_upstream_of_or_within ISO
IEA 		MGI:1856328 (PMID:12673830)
GO_REF:0000107 		RGD
Ensembl		 PMID:12673830 GO_REF:0000107 NCBI chr  X:51,070,098...53,437,845
Ensembl chr  X:51,070,273...53,437,835 		JBrowse link
G Mxra8 matrix remodeling associated 8 involved_in IEA
ISO 		GO_REF:0000107
(PMID:14603461) 		Ensembl
RGD		 PMID:14603461 GO_REF:0000107 NCBI chr 5:171,731,153...171,735,879
Ensembl chr 5:171,731,353...171,735,879 		JBrowse link
negative regulation of establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:16056236 RGD:2317116 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
G Ttpa alpha tocopherol transfer protein involved_in ISO (PMID:19923370) RGD PMID:19923370 NCBI chr 5:38,294,415...38,315,471
Ensembl chr 5:38,292,665...38,315,804 		JBrowse link
regulation of establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgra2 adhesion G protein-coupled receptor A2 acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:4949903 (PMID:21421844)
GO_REF:0000107
(PMID:28288111) 		RGD
Ensembl		 PMID:21421844 PMID:28288111 GO_REF:0000107 NCBI chr16:64,932,964...64,971,433
Ensembl chr16:71,636,164...71,674,154 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs involved_in ISO
IEA 		(PMID:28803732)
GO_REF:0000107 		RGD
Ensembl		 PMID:28803732 GO_REF:0000107 NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:62,898,668...62,965,270 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      cellular developmental process 4967
        cell development 3432
          establishment of blood-brain barrier 21
            establishment of endothelial blood-brain barrier 3
            establishment of glial blood-brain barrier 2
            negative regulation of establishment of blood-brain barrier 2
            positive regulation of establishment of blood-brain barrier 0
            regulation of establishment of blood-brain barrier + 4
Path 2
Term Annotations click to browse term
  biological_process 20668
    developmental process 7294
      anatomical structure development 6777
        multicellular organism development 5422
          system development 4701
            nervous system development 2936
              central nervous system development 1250
                establishment of blood-brain barrier 21
                  establishment of endothelial blood-brain barrier 3
                  establishment of glial blood-brain barrier 2
                  negative regulation of establishment of blood-brain barrier 2
                  positive regulation of establishment of blood-brain barrier 0
                  regulation of establishment of blood-brain barrier + 4
paths to the root