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ONTOLOGY REPORT - ANNOTATIONS

Term:establishment of blood-brain barrier
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Accession:GO:0060856 term browser browse the term
Definition:Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
Synonyms:exact_synonym: establishment of BBB
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa


show annotations for term's descendants           Sort by:
establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IMP RGD PMID:22049154 RGD:8657330 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Bpgm bisphosphoglycerate mutase acts_upstream_of_or_within ISO MGI:6506869 (PMID:32966787) RGD PMID:32966787 NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:25083995)		 Ensembl
RGD		 PMID:25083995 GO_REF:0000107 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Fzd4 frizzled class receptor 4 acts_upstream_of_or_within ISO MGI:98961 (PMID:23217714), (PMID:30478038) RGD PMID:23217714 PMID:30478038 NCBI chr 1:143,279,934...143,288,799
Ensembl chr 1:143,280,065...143,285,724 		JBrowse link
G Lrp5 LDL receptor related protein 5 acts_upstream_of_or_within ISO MGI:2183279 (PMID:25083995) RGD PMID:25083995 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:5299216 (PMID:25083995) RGD PMID:25083995 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Lsr lipolysis stimulated lipoprotein receptor involved_in ISO
IBA		 (MGI:5700280|PMID:25753034)
(PMID:25753034)
GO_REF:0000033		 RGD
GO_Central		 PMID:25753034 GO_REF:0000033 MGI:5700280 NCBI chr 1:86,185,769...86,201,952
Ensembl chr 1:86,186,431...86,201,952 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid involved_in
NOT|involved_in		 ISO (MGI:5571503|PMID:24828040)
(PMID:27008858)
(PMID:24828040)
(MGI:5789479|PMID:27008858)		 RGD PMID:24828040 PMID:27008858 MGI:5571503 MGI:5789479 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690 		JBrowse link
G Ndp norrin cystine knot growth factor NDP acts_upstream_of_or_within ISO MGI:98961 (PMID:23217714), (PMID:30478038) RGD PMID:23217714 PMID:30478038 NCBI chr  X:5,796,487...5,820,934
Ensembl chr  X:5,796,487...5,820,934 		JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B acts_upstream_of_or_within ISO (PMID:28675177) RGD PMID:28675177 NCBI chr13:22,907,105...22,932,200
Ensembl chr13:22,907,109...22,932,229 		JBrowse link
G Wnt7a Wnt family member 7A acts_upstream_of_or_within ISO MGI:102570|MGI:108520 (PMID:30478038) RGD PMID:30478038 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981 		JBrowse link
establishment of endothelial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, sub-family B member 1B IMP RGD PMID:16850390 RGD:1598561 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Cldn3 claudin 3 involved_in ISO (MGI:6368952|PMID:12734665)
(PMID:12734665)		 RGD PMID:12734665 MGI:6368952 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001 		JBrowse link
G Foxp3 forkhead box P3 IEP RGD PMID:31027862 RGD:38549575 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
establishment of glial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmd dystrophin acts_upstream_of_or_within ISO MGI:1856328 (PMID:12673830) RGD PMID:12673830 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Mxra8 matrix remodeling associated 8 involved_in ISO
IEA		 (MGI:5554369|PMID:14603461)
(PMID:14603461)
GO_REF:0000107		 RGD
Ensembl		 PMID:14603461 GO_REF:0000107 MGI:5554369 NCBI chr 5:166,448,919...166,453,645
Ensembl chr 5:166,449,154...166,453,636 		JBrowse link
negative regulation of establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:16056236 RGD:2317116 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Ttpa alpha tocopherol transfer protein involved_in ISO
IEA		 (MGI:4461120|PMID:19923370)
GO_REF:0000107		 RGD
Ensembl		 PMID:19923370 GO_REF:0000107 MGI:4461120 NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073 		JBrowse link
regulation of establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgra2 adhesion G protein-coupled receptor A2 involved_in
acts_upstream_of_or_within		 ISO (MGI:6102983|PMID:28288111)
MGI:4949903 (PMID:21421844)		 RGD PMID:21421844 PMID:28288111 MGI:6102983 NCBI chr16:64,932,964...64,971,433
Ensembl chr16:64,933,315...64,971,483 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs involved_in ISO (MGI:6114565|PMID:28803732) RGD PMID:28803732 MGI:6114565 NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    cellular process 19326
      cellular developmental process 4749
        cell development 3312
          establishment of blood-brain barrier 20
            establishment of endothelial blood-brain barrier 3
            establishment of glial blood-brain barrier 2
            negative regulation of establishment of blood-brain barrier 2
            positive regulation of establishment of blood-brain barrier 0
            regulation of establishment of blood-brain barrier + 4
Path 2
Term Annotations click to browse term
  biological_process 20134
    developmental process 7034
      anatomical structure development 6553
        multicellular organism development 5285
          system development 4565
            nervous system development 2825
              central nervous system development 1212
                establishment of blood-brain barrier 20
                  establishment of endothelial blood-brain barrier 3
                  establishment of glial blood-brain barrier 2
                  negative regulation of establishment of blood-brain barrier 2
                  positive regulation of establishment of blood-brain barrier 0
                  regulation of establishment of blood-brain barrier + 4
paths to the root