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ONTOLOGY REPORT - ANNOTATIONS


Term:establishment of blood-brain barrier
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Accession:GO:0060856 term browser browse the term
Definition:Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.
Synonyms:exact_synonym: establishment of BBB


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establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IMP RGD PMID:22049154 RGD:8657330 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Lsr lipolysis stimulated lipoprotein receptor ISO (MGI:5700280|PMID:25753034) RGD PMID:25753034 MGI:5700280 NCBI chr 1:89,383,515...89,399,041
Ensembl chr 1:89,383,519...89,399,041
JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A NOT ISO (MGI:5571503|PMID:24828040)
(MGI:5789479|PMID:27008858)
RGD PMID:24828040 PMID:27008858 MGI:5571503 MGI:5789479 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745
JBrowse link
central nervous system vasculogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 IEA
ISO
GO_REF:0000107
MGI:2148569 (MGI:3821408|PMID:19023080)
Ensembl
RGD
PMID:19023080 GO_REF:0000107 MGI:3821408 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Eng endoglin ISO (PMID:7894484) RGD PMID:7894484 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Rtn4 reticulon 4 ISS
ISO
GO_REF:0000024
(MGI:5492189|PMID:23625008)
UniProt
RGD
PMID:23625008 GO_REF:0000024 MGI:5492189 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458
JBrowse link
G Wnt7a Wnt family member 7A ISO MGI:98962 (MGI:3821408|PMID:19023080) RGD PMID:19023080 MGI:3821408 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link
G Wnt7b Wnt family member 7B ISO MGI:98961 (MGI:3821408|PMID:19023080) RGD PMID:19023080 MGI:3821408 NCBI chr 7:126,423,418...126,465,724
Ensembl chr 7:126,420,656...126,465,723
JBrowse link
establishment of endothelial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B IMP RGD PMID:16850390 RGD:1598561 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cldn3 claudin 3 ISO (MGI:6368952|PMID:12734665) RGD PMID:12734665 MGI:6368952 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Foxp3 forkhead box P3 IEP RGD PMID:31027862 RGD:38549575 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
establishment of glial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmd dystrophin ISO MGI:1856328 (MGI:3612931|PMID:12673830) RGD PMID:12673830 MGI:3612931 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Mxra8 matrix remodeling associated 8 IEA
ISO
GO_REF:0000107
(PMID:14603461)
Ensembl
RGD
PMID:14603461 GO_REF:0000107 NCBI chr 5:173,288,200...173,292,926
Ensembl chr 5:173,288,447...173,292,929
JBrowse link
negative regulation of establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:16056236 RGD:2317116 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ttpa alpha tocopherol transfer protein ISO (MGI:4461120|PMID:19923370) RGD PMID:19923370 MGI:4461120 NCBI chr 5:34,007,926...34,029,315
Ensembl chr 5:34,007,920...34,028,452
JBrowse link
regulation of establishment of blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgra2 adhesion G protein-coupled receptor A2 ISO MGI:4949903 (MGI:4949015|PMID:21421844), (MGI:6102983|PMID:28288111) RGD PMID:21421844 PMID:28288111 MGI:4949015 MGI:6102983 NCBI chr16:69,094,587...69,133,015
Ensembl chr16:69,095,936...69,132,584
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs ISO (MGI:6114565|PMID:28803732) RGD PMID:28803732 MGI:6114565 NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20045
    cellular process 18859
      cellular developmental process 4464
        cell development 2447
          establishment of blood-brain barrier 17
            establishment of endothelial blood-brain barrier + 8
            establishment of glial blood-brain barrier 2
            negative regulation of establishment of blood-brain barrier 2
            positive regulation of establishment of blood-brain barrier 0
            regulation of establishment of blood-brain barrier + 4
Path 2
Term Annotations click to browse term
  biological_process 20045
    developmental process 6824
      anatomical structure development 6290
        multicellular organism development 5766
          system development 5298
            nervous system development 2729
              central nervous system development 1270
                establishment of blood-brain barrier 17
                  establishment of endothelial blood-brain barrier + 8
                  establishment of glial blood-brain barrier 2
                  negative regulation of establishment of blood-brain barrier 2
                  positive regulation of establishment of blood-brain barrier 0
                  regulation of establishment of blood-brain barrier + 4
paths to the root