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ONTOLOGY REPORT - ANNOTATIONS

Term:cell fate commitment involved in formation of primary germ layer
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Accession:GO:0060795 term browser browse the term
Definition:The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.

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cell fate commitment involved in formation of primary germ layer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) BHF-UCL PMID:19736317 NCBI chrNW_004955583:995,707...1,003,202 JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nodal nodal growth differentiation factor acts_upstream_of_or_within ISO (PMID:14511481) MGI PMID:14511481 NCBI chrNW_004955437:20,828,448...20,835,486
Ensembl chrNW_004955437:20,828,448...20,835,628 		JBrowse link
ectodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elf5 E74 like ETS transcription factor 5 acts_upstream_of_or_within ISO (PMID:25446535) MGI PMID:25446535 NCBI chrNW_004955422:11,751,073...11,779,313
Ensembl chrNW_004955422:11,750,774...11,780,310 		JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor acts_upstream_of_or_within ISO (PMID:25446535) MGI PMID:25446535 NCBI chrNW_004955407:37,747,152...37,764,170
Ensembl chrNW_004955407:37,747,000...37,765,237 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (PMID:10742100) MGI PMID:10742100 NCBI chrNW_004955583:995,707...1,003,202 JBrowse link
endodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc73 cell division cycle 73 involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chrNW_004955406:30,533,919...30,665,812
Ensembl chrNW_004955406:30,533,060...30,665,812 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO (PMID:12194849) MGI PMID:12194849 NCBI chrNW_004955420:29,030,716...29,047,447
Ensembl chrNW_004955420:29,030,716...29,047,449 		JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chrNW_004955414:26,347,508...26,373,726
Ensembl chrNW_004955414:26,347,508...26,373,785 		JBrowse link
G Leo1 LEO1 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chrNW_004955409:2,711,475...2,727,879
Ensembl chrNW_004955409:2,711,564...2,727,755 		JBrowse link
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chrNW_004955468:166,477...172,200 JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (PMID:10742100) MGI PMID:10742100 NCBI chrNW_004955583:995,707...1,003,202 JBrowse link
G Rtf1 RTF1 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chrNW_004955416:8,237,439...8,293,802
Ensembl chrNW_004955416:8,237,439...8,293,802 		JBrowse link
endodermal cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox17 SRY-box transcription factor 17 acts_upstream_of_or_within ISO (PMID:20308546) MGI PMID:20308546 NCBI chrNW_004955454:13,689,403...13,690,019 JBrowse link
endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin acts_upstream_of_or_within ISO (PMID:21245162) MGI PMID:21245162 NCBI chrNW_004955430:19,280,460...19,287,060
Ensembl chrNW_004955430:19,281,602...19,286,867 		JBrowse link
G Hnf1b HNF1 homeobox B acts_upstream_of_or_within ISO (PMID:18635606) MGI PMID:18635606 NCBI chrNW_004955451:320,283...371,420
Ensembl chrNW_004955451:320,283...371,420 		JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within ISO (PMID:20713518) MGI PMID:20713518 NCBI chrNW_004955413:6,561,323...6,565,770 JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (PMID:20713518) MGI PMID:20713518 NCBI chrNW_004955583:995,707...1,003,202 JBrowse link
G Sox17 SRY-box transcription factor 17 involved_in ISO (MGI:4946573|PMID:21305474) BHF-UCL PMID:21305474 MGI:4946573 NCBI chrNW_004955454:13,689,403...13,690,019 JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (PMID:21245162) MGI PMID:21245162 NCBI chrNW_004955420:10,671,888...10,674,080
Ensembl chrNW_004955420:10,671,978...10,672,934 		JBrowse link
mesodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nanog Nanog homeobox acts_upstream_of
acts_upstream_of_or_within		 ISO (PMID:16801560) MGI PMID:16801560 NCBI chrNW_004955413:6,561,323...6,565,770 JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (PMID:10742100) MGI PMID:10742100 NCBI chrNW_004955583:995,707...1,003,202 JBrowse link
G Smad1 SMAD family member 1 acts_upstream_of_or_within ISO (PMID:16801560) MGI PMID:16801560 NCBI chrNW_004955428:1,357,398...1,429,521
Ensembl chrNW_004955428:1,361,085...1,429,948 		JBrowse link
mesodermal cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within ISO (PMID:7657163) MGI PMID:7657163 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303 		JBrowse link
mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 involved_in ISO (MGI:3768605|PMID:17785448) UniProt PMID:17785448 MGI:3768605 NCBI chrNW_004955444:8,336,071...8,655,041
Ensembl chrNW_004955444:8,495,530...8,655,100 		JBrowse link
G Hoxa11 homeobox A11 involved_in ISO (MGI:3768605|PMID:17785448) UniProt PMID:17785448 MGI:3768605 NCBI chrNW_004955410:28,875,780...28,879,643
Ensembl chrNW_004955410:28,877,055...28,879,465 		JBrowse link
G Pax2 paired box 2 involved_in ISO (MGI:3768605|PMID:17785448) UniProt PMID:17785448 MGI:3768605 NCBI chrNW_004955485:9,351,913...9,430,607
Ensembl chrNW_004955485:9,350,087...9,430,607 		JBrowse link
G Sfrp2 secreted frizzled related protein 2 acts_upstream_of ISO (PMID:17462603) MGI PMID:17462603 NCBI chrNW_004955471:8,103,937...8,112,596
Ensembl chrNW_004955471:8,103,783...8,112,321 		JBrowse link
G Six2 SIX homeobox 2 involved_in ISO (MGI:3768605|PMID:17785448) UniProt PMID:17785448 MGI:3768605 NCBI chrNW_004955441:12,029,530...12,033,214
Ensembl chrNW_004955441:12,029,480...12,033,214 		JBrowse link
G Tbx6 T-box transcription factor 6 acts_upstream_of_or_within ISO (PMID:9490412) MGI PMID:9490412 NCBI chrNW_004955493:6,888,832...6,894,840
Ensembl chrNW_004955493:6,888,832...6,894,831 		JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd7 frizzled class receptor 7 involved_in ISO (PMID:18681827) BHF-UCL PMID:18681827 NCBI chrNW_004955457:12,729,277...12,733,057
Ensembl chrNW_004955457:12,731,279...12,732,979 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) BHF-UCL PMID:20559569 NCBI chrNW_004955425:7,353,964...7,357,599 JBrowse link
G Sfrp2 secreted frizzled related protein 2 acts_upstream_of_or_within ISO (PMID:17462603) MGI PMID:17462603 NCBI chrNW_004955471:8,103,937...8,112,596
Ensembl chrNW_004955471:8,103,783...8,112,321 		JBrowse link
paraxial mesodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A acts_upstream_of_or_within ISO (PMID:9126297) MGI PMID:9126297 NCBI chrNW_004955581:351,375...382,541
Ensembl chrNW_004955581:350,889...382,541 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:20559569) BHF-UCL PMID:20559569 NCBI chrNW_004955581:351,375...382,541
Ensembl chrNW_004955581:350,889...382,541 		JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) BHF-UCL PMID:20559569 NCBI chrNW_004955425:7,353,964...7,357,599 JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO (PMID:16943278) MGI PMID:16943278 NCBI chrNW_004955510:5,812,571...5,936,312
Ensembl chrNW_004955510:5,905,008...5,936,312 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO (PMID:16943278) MGI PMID:16943278 NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    developmental process 5853
      anatomical structure formation involved in morphogenesis 1158
        formation of primary germ layer 122
          cell fate commitment involved in formation of primary germ layer 28
            ectodermal cell fate commitment + 4
            endodermal cell fate commitment + 13
            mesodermal cell fate commitment + 15
Path 2
Term Annotations click to browse term
  biological_process 12346
    developmental process 5853
      anatomical structure development 5540
        multicellular organism development 4550
          embryo development 1224
            embryonic morphogenesis 641
              gastrulation 186
                formation of primary germ layer 122
                  cell fate commitment involved in formation of primary germ layer 28
                    ectodermal cell fate commitment + 4
                    endodermal cell fate commitment + 13
                    mesodermal cell fate commitment + 15
paths to the root