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ONTOLOGY REPORT - ANNOTATIONS


Term:cell fate commitment involved in formation of primary germ layer
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Accession:GO:0060795 term browser browse the term
Definition:The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.



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cell fate commitment involved in formation of primary germ layer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POU5F1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) BHF-UCL PMID:19736317 NCBI chr 6:30,910,421...30,916,465
Ensembl chr 6:31,775,343...31,781,426
JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NODAL nodal growth differentiation factor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2677178|PMID:14511481) MGI
Ensembl
PMID:14511481 GO_REF:0000107 MGI:2677178 NCBI chr10:66,906,866...66,916,938
Ensembl chr10:69,433,959...69,443,972
JBrowse link
ectodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELF5 E74 like ETS transcription factor 5 acts_upstream_of_or_within ISO (MGI:5616945|PMID:25446535) MGI PMID:25446535 MGI:5616945 NCBI chr11:34,453,550...34,486,519
Ensembl chr11:34,329,889...34,362,770
JBrowse link
G ETS2 ETS proto-oncogene 2, transcription factor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5616945|PMID:25446535) MGI
Ensembl
PMID:25446535 GO_REF:0000107 MGI:5616945 NCBI chr21:25,158,457...25,178,035
Ensembl chr21:38,512,835...38,527,651
JBrowse link
G POU5F1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (MGI:1355046|PMID:10742100) MGI PMID:10742100 MGI:1355046 NCBI chr 6:30,910,421...30,916,465
Ensembl chr 6:31,775,343...31,781,426
JBrowse link
endodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC73 cell division cycle 73 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:168,581,730...168,710,915
Ensembl chr 1:172,875,365...173,004,934
JBrowse link
G CTNNB1 catenin beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3625553|PMID:12194849) Ensembl
MGI
PMID:12194849 GO_REF:0000107 MGI:3625553 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030
JBrowse link
G CTR9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:10,884,353...10,913,246
Ensembl chr11:10,610,892...10,639,808
JBrowse link
G LEO1 LEO1 homolog, Paf1/RNA polymerase II complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:30,879,431...30,913,361
Ensembl chr15:49,208,132...49,241,055
JBrowse link
G PAF1 PAF1 homolog, Paf1/RNA polymerase II complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:36,484,099...36,489,364
Ensembl chr19:45,031,819...45,037,169
JBrowse link
G POU5F1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (MGI:1355046|PMID:10742100) MGI PMID:10742100 MGI:1355046 NCBI chr 6:30,910,421...30,916,465
Ensembl chr 6:31,775,343...31,781,426
JBrowse link
G RTF1 RTF1 homolog, Paf1/RNA polymerase II complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:20,355,927...20,424,153
Ensembl chr15:38,599,163...38,662,100
JBrowse link
endodermal cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4442295|PMID:20308546) MGI
Ensembl
PMID:20308546 GO_REF:0000107 MGI:4442295 NCBI chr18:15,411,764...15,444,402 JBrowse link
G SOX17 SRY-box transcription factor 17 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4442295|PMID:20308546) MGI
Ensembl
PMID:20308546 GO_REF:0000107 MGI:4442295 NCBI chr 8:50,883,088...50,885,542
Ensembl chr 8:48,257,287...48,259,808
JBrowse link
endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4887279|PMID:21245162) MGI
TreeGrafter
PMID:21245162 GO_REF:0000118 MGI:4887279 NCBI chr 3:27,601,829...27,608,701
Ensembl chr 3:27,925,086...27,930,274
JBrowse link
G HNF1B HNF1 homeobox B acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3807614|PMID:18635606) MGI
Ensembl
PMID:18635606 GO_REF:0000107 MGI:3807614 NCBI chr17:19,333,485...19,392,147
Ensembl chr17:19,633,424...19,691,863
JBrowse link
G NANOG Nanog homeobox acts_upstream_of_or_within ISO (PMID:20713518) MGI PMID:20713518 NCBI chr12:7,913,037...7,919,715 JBrowse link
G POU5F1 POU class 5 homeobox 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:20713518) MGI
Ensembl
PMID:20713518 GO_REF:0000107 NCBI chr 6:30,910,421...30,916,465
Ensembl chr 6:31,775,343...31,781,426
JBrowse link
G SOX17 SRY-box transcription factor 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:50,883,088...50,885,542
Ensembl chr 8:48,257,287...48,259,808
JBrowse link
G SOX2 SRY-box transcription factor 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:21245162) MGI
Ensembl
PMID:21245162 GO_REF:0000107 NCBI chr 3:178,744,881...178,747,392
Ensembl chr 3:186,922,705...186,923,662
JBrowse link
mesodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NANOG Nanog homeobox acts_upstream_of_or_within ISO (MGI:3654744|PMID:16801560) MGI PMID:16801560 MGI:3654744 NCBI chr12:7,913,037...7,919,715 JBrowse link
G POU5F1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (MGI:1355046|PMID:10742100) MGI PMID:10742100 MGI:1355046 NCBI chr 6:30,910,421...30,916,465
Ensembl chr 6:31,775,343...31,781,426
JBrowse link
G SMAD1 SMAD family member 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3654744|PMID:16801560) MGI
Ensembl
PMID:16801560 GO_REF:0000107 MGI:3654744 NCBI chr 4:137,822,269...137,899,700
Ensembl chr 4:149,481,836...149,558,135
JBrowse link
mesodermal cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:76261|PMID:7657163) MGI
Ensembl
PMID:7657163 GO_REF:0000107 MGI:76261 NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752
JBrowse link
mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EYA1 EYA transcriptional coactivator and phosphatase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:67,728,057...68,060,069
Ensembl chr 8:69,387,769...69,551,829
JBrowse link
G HOXA11 homeobox A11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:27,826,003...27,829,757
Ensembl chr 7:27,424,759...27,429,103
JBrowse link
G PAX2 paired box 2 involved_in ISO (MGI:3768605|PMID:17785448) UniProt PMID:17785448 MGI:3768605 NCBI chr10:97,344,978...97,429,086
Ensembl chr10:100,822,676...100,904,028
JBrowse link
G SFRP2 secreted frizzled related protein 2 acts_upstream_of
involved_in
ISO
IEA
(MGI:3711603|PMID:17462603) MGI
Ensembl
PMID:17462603 GO_REF:0000107 MGI:3711603 NCBI chr 4:146,123,075...146,131,543
Ensembl chr 4:157,944,733...157,953,258
JBrowse link
G SIX2 SIX homeobox 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:45,109,414...45,113,887
Ensembl chr2A:46,039,582...46,044,035
JBrowse link
G TBX6 T-box transcription factor 6 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2447720|PMID:9490412) MGI
Ensembl
PMID:9490412 GO_REF:0000107 MGI:2447720 Ensembl chr16:30,460,305...30,467,070 JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FZD7 frizzled class receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:89,290,929...89,294,873
Ensembl chr2B:207,439,942...207,446,283
JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:68,440,626...68,441,935
Ensembl chr15:87,645,768...87,647,210
JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:48,950,704...48,953,815
Ensembl chr10:51,084,027...51,089,776
JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:68,440,626...68,441,935
Ensembl chr15:87,645,768...87,647,210
JBrowse link
G SFRP2 secreted frizzled related protein 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3711603|PMID:17462603) MGI
Ensembl
PMID:17462603 GO_REF:0000107 MGI:3711603 NCBI chr 4:146,123,075...146,131,543
Ensembl chr 4:157,944,733...157,953,258
JBrowse link
paraxial mesodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXC2 forkhead box C2 acts_upstream_of_or_within ISO (MGI:86990|PMID:9106663) MGI PMID:9106663 MGI:86990 NCBI chr16:67,237,476...67,239,545 JBrowse link
G WNT3A Wnt family member 3A acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:86727|PMID:9126297) MGI
Ensembl
PMID:9126297 GO_REF:0000107 MGI:86727 NCBI chr 1:203,409,294...203,463,214
Ensembl chr 1:208,628,706...208,674,469
JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT3A Wnt family member 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:203,409,294...203,463,214
Ensembl chr 1:208,628,706...208,674,469
JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:48,950,704...48,953,815
Ensembl chr10:51,084,027...51,089,776
JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1A bone morphogenetic protein receptor type 1A acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3702797|PMID:16943278) MGI
Ensembl
PMID:16943278 GO_REF:0000107 MGI:3702797 NCBI chr10:83,185,040...83,353,239
Ensembl chr10:86,837,469...86,912,912
JBrowse link
G FGFR1 fibroblast growth factor receptor 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3702797|PMID:16943278) MGI
Ensembl
PMID:16943278 GO_REF:0000107 MGI:3702797 NCBI chr 8:37,713,133...37,773,098
Ensembl chr 8:34,890,147...34,948,904
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16309
    developmental process 6535
      anatomical structure formation involved in morphogenesis 1252
        formation of primary germ layer 132
          cell fate commitment involved in formation of primary germ layer 31
            ectodermal cell fate commitment + 4
            endodermal cell fate commitment + 15
            mesodermal cell fate commitment + 17
Path 2
Term Annotations click to browse term
  biological_process 16309
    developmental process 6535
      anatomical structure development 6144
        multicellular organism development 4947
          embryo development 1309
            embryonic morphogenesis 681
              gastrulation 203
                formation of primary germ layer 132
                  cell fate commitment involved in formation of primary germ layer 31
                    ectodermal cell fate commitment + 4
                    endodermal cell fate commitment + 15
                    mesodermal cell fate commitment + 17
paths to the root