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ONTOLOGY REPORT - ANNOTATIONS

Term:cell fate commitment involved in formation of primary germ layer
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Accession:GO:0060795 term browser browse the term
Definition:The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.


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cell fate commitment involved in formation of primary germ layer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nodal nodal growth differentiation factor acts_upstream_of_or_within ISO (PMID:14511481) RGD PMID:14511481 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837 		JBrowse link
ectodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elf5 E74 like ETS transcription factor 5 acts_upstream_of_or_within ISO MGI:95456 (PMID:25446535) RGD PMID:25446535 NCBI chr 3:89,808,837...89,836,977
Ensembl chr 3:89,797,880...89,836,973 		JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor acts_upstream_of_or_within ISO MGI:1335079 (PMID:25446535) RGD PMID:25446535 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (PMID:10742100) RGD PMID:10742100 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
endodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc73 cell division cycle 73 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:19345177)
(MGI:3849235|PMID:19345177)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:19345177 GO_REF:0000024 GO_REF:0000107 MGI:3849235 NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1858007|MGI:2148567 (PMID:12194849)		 Ensembl
RGD		 PMID:12194849 GO_REF:0000107 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:3849235|PMID:19345177) RGD PMID:19345177 MGI:3849235 NCBI chr 1:165,137,277...165,167,303
Ensembl chr 1:165,137,215...165,167,303 		JBrowse link
G Leo1 LEO1 homolog, Paf1/RNA polymerase II complex component involved_in ISS
ISO		 GO_REF:0000024
(PMID:19345177)
(MGI:3849235|PMID:19345177)		 UniProt
RGD		 PMID:19345177 GO_REF:0000024 MGI:3849235 NCBI chr 8:76,199,547...76,223,983
Ensembl chr 8:76,199,099...76,223,983 		JBrowse link
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component involved_in ISS
ISO		 GO_REF:0000024
(MGI:3849235|PMID:19345177)		 UniProt
RGD		 PMID:19345177 GO_REF:0000024 MGI:3849235 NCBI chr 1:83,683,654...83,689,233
Ensembl chr 1:83,668,813...83,689,237 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (PMID:10742100) RGD PMID:10742100 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) involved_in ISO (MGI:3849235|PMID:19345177) RGD PMID:19345177 MGI:3849235 NCBI chr 3:106,659,363...106,718,956
Ensembl chr 3:106,659,308...106,718,970 		JBrowse link
endodermal cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:20308546)		 Ensembl
RGD		 PMID:20308546 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Sox17 SRY-box transcription factor 17 acts_upstream_of_or_within ISO (PMID:20308546) RGD PMID:20308546 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:3774028 (PMID:21245162)		 GO_Central
RGD		 PMID:21245162 GO_REF:0000033 NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316 		JBrowse link
G Hnf1b HNF1 homeobox B involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857856 (PMID:18635606)		 Ensembl
RGD		 PMID:18635606 GO_REF:0000107 NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888 		JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within ISO (PMID:20713518) RGD PMID:20713518 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (PMID:20713518) RGD PMID:20713518 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Sox17 SRY-box transcription factor 17 involved_in ISO (MGI:4946573|PMID:21305474)
(PMID:21305474)		 RGD PMID:21305474 MGI:4946573 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (PMID:21245162) RGD PMID:21245162 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
mesodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nanog Nanog homeobox acts_upstream_of_or_within ISO MGI:109452 (PMID:16801560) RGD PMID:16801560 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO (PMID:10742100) RGD PMID:10742100 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Smad1 SMAD family member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1919200 (PMID:16801560)		 Ensembl
RGD		 PMID:16801560 GO_REF:0000107 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
mesodermal cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857137 (PMID:7657163)		 Ensembl
RGD		 PMID:7657163 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 involved_in ISO (MGI:3768605|PMID:17785448)
(PMID:17785448)		 RGD PMID:17785448 MGI:3768605 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Hoxa11 homeobox A11 involved_in ISO (MGI:3768605|PMID:17785448)
(PMID:17785448)		 RGD PMID:17785448 MGI:3768605 NCBI chr 4:81,342,527...81,346,189
Ensembl chr 4:81,342,528...81,346,232 		JBrowse link
G Pax2 paired box 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17785448)
(MGI:3768605|PMID:17785448)		 UniProt
RGD		 PMID:17785448 GO_REF:0000024 MGI:3768605 NCBI chr 1:243,616,509...243,697,454
Ensembl chr 1:243,616,606...243,695,321 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of ISO MGI:98956 (PMID:17462603) RGD PMID:17462603 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Six2 SIX homeobox 2 involved_in ISO (MGI:3768605|PMID:17785448) RGD PMID:17785448 MGI:3768605 NCBI chr 6:8,974,859...8,981,345
Ensembl chr 6:8,967,157...8,981,193 		JBrowse link
G Tbx6 T-box transcription factor 6 acts_upstream_of_or_within ISO MGI:2447721 (PMID:9490412) RGD PMID:9490412 NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593 		JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd7 frizzled class receptor 7 involved_in ISO (PMID:18681827) RGD PMID:18681827 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781 		JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560)
(PMID:18593560)		 RGD PMID:18593560 MGI:4441249 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:98956 (PMID:17462603) RGD PMID:17462603 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
paraxial mesodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxc2 forkhead box C2 acts_upstream_of_or_within ISO MGI:1857865 (PMID:9106663) RGD PMID:9106663 NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737 		JBrowse link
G Wnt3a Wnt family member 3A acts_upstream_of_or_within ISO MGI:1857489 (PMID:9126297) RGD PMID:9126297 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO MGI:95522 (PMID:16943278) RGD PMID:16943278 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO MGI:1338938 (PMID:16943278) RGD PMID:16943278 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    developmental process 7034
      anatomical structure formation involved in morphogenesis 1364
        formation of primary germ layer 139
          cell fate commitment involved in formation of primary germ layer 31
            ectodermal cell fate commitment + 4
            endodermal cell fate commitment + 15
            mesodermal cell fate commitment + 17
Path 2
Term Annotations click to browse term
  biological_process 20134
    developmental process 7034
      anatomical structure development 6553
        multicellular organism development 5285
          embryo development 1362
            embryonic morphogenesis 704
              gastrulation 219
                formation of primary germ layer 139
                  cell fate commitment involved in formation of primary germ layer 31
                    ectodermal cell fate commitment + 4
                    endodermal cell fate commitment + 15
                    mesodermal cell fate commitment + 17
paths to the root