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ONTOLOGY REPORT - ANNOTATIONS

Term:multicellular organismal-level iron ion homeostasis
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Accession:GO:0060586 term browser browse the term
Definition:A chemical homeostatic process involved in the maintenance of a steady state level of iron within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.
Synonyms:exact_synonym: multicellular organismal iron ion homeostasis


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multicellular organismal-level iron ion homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank1 ankyrin 1 acts_upstream_of_or_within ISO MGI:5502651 (PMID:23390527) RGD PMID:23390527 NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759 		JBrowse link
G B2m beta-2 microglobulin acts_upstream_of_or_within ISO (PMID:11113132) RGD PMID:11113132 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO
ISS		 (MGI:4352622|PMID:19252488)
GO_REF:0000024
(PMID:26582087), (PMID:28335084), (PMID:32464486)		 RGD
UniProt		 PMID:19252488 PMID:26582087 PMID:28335084 PMID:32464486 GO_REF:0000024 MGI:4352622 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Btbd9 BTB domain containing 9 acts_upstream_of_or_within ISO MGI:4127237 (PMID:22678064) RGD PMID:22678064 NCBI chr20:8,286,337...8,645,567
Ensembl chr20:8,288,711...8,643,960 		JBrowse link
G Cybrd1 cytochrome b reductase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:30272000)		 UniProt
RGD		 PMID:30272000 GO_REF:0000024 NCBI chr 3:55,934,874...55,962,132
Ensembl chr 3:55,934,874...55,962,108 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2679454 (PMID:17932563)		 Ensembl
RGD		 PMID:17932563 GO_REF:0000107 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573 		JBrowse link
G Epas1 endothelial PAS domain protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:109169 (PMID:22128145)		 Ensembl
RGD		 PMID:22128145 GO_REF:0000107 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Epb42 erythrocyte membrane protein band 4.2 acts_upstream_of_or_within ISO MGI:2182816 (PMID:10359562) RGD PMID:10359562 NCBI chr 3:107,979,709...107,997,932
Ensembl chr 3:107,979,713...107,997,932 		JBrowse link
G Fbxl5 F-box and leucine-rich repeat protein 5 acts_upstream_of_or_within ISO MGI:1928268|MGI:5295288 (PMID:21907140) RGD PMID:21907140 NCBI chr14:67,305,109...67,347,383
Ensembl chr14:67,267,801...67,347,383 		JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within ISO MGI:1858114 (PMID:17003376) RGD PMID:17003376 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Hamp hepcidin antimicrobial peptide involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:12469120)
GO_REF:0000107
MGI:3701082|MGI:4351741 (PMID:16574947), (PMID:20113314), (PMID:20530874), (PMID:20811044), (PMID:22128145), (PMID:23637785), (PMID:24357728), (PMID:24561287), (PMID:24646470)		 RGD
Ensembl		 PMID:12469120 PMID:16574947 PMID:20113314 PMID:20530874 PMID:20811044 More... GO_REF:0000107 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hfe homeostatic iron regulator involved_in
acts_upstream_of_or_within		 IEP
ISO		 (PMID:21173098)
MGI:1934013|MGI:2181388|MGI:2385353|MGI:3775648 (PMID:10077651), (PMID:15131800), (PMID:15914561), (PMID:21059897), (PMID:22960056)		 RGD PMID:10077651 PMID:15131800 PMID:15914561 PMID:21059897 PMID:21173098 More... RGD:1582699 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Hjv hemojuvelin BMP co-receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
UniProtKB:Q92859 (PMID:16075058)
MGI:3587746|MGI:3587747 (PMID:16075058), (PMID:19751239), (PMID:22960056), (PMID:24409331)		 Ensembl
RGD		 PMID:16075058 PMID:19751239 PMID:22960056 PMID:24409331 GO_REF:0000107 NCBI chr 2:184,065,944...184,069,851
Ensembl chr 2:184,065,970...184,069,850 		JBrowse link
G Hmox1 heme oxygenase 1 involved_in ISO
IEA		 (PMID:9884342)
GO_REF:0000107		 RGD
Ensembl		 PMID:9884342 GO_REF:0000107 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Htt huntingtin acts_upstream_of_or_within ISO MGI:1857180 (PMID:11092755) RGD PMID:11092755 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Hyal2 hyaluronidase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3836764 (PMID:18772348)		 Ensembl
RGD		 PMID:18772348 GO_REF:0000107 NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850 		JBrowse link
G Ireb2 iron responsive element binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2152883 (PMID:21907140)		 Ensembl
RGD		 PMID:21907140 GO_REF:0000107 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Mir122 microRNA 122 acts_upstream_of_or_within ISO MGI:2676805 (PMID:21364282) RGD PMID:21364282 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir17 microRNA 17 acts_upstream_of_or_within ISO (PMID:21364282) RGD PMID:21364282 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO MGI:1934018 (PMID:29624734) RGD PMID:29624734 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972 		JBrowse link
G Neo1 neogenin 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 UniProtKB:Q6ZVN8 (PMID:16075058)
GO_REF:0000107		 RGD
Ensembl		 PMID:16075058 GO_REF:0000107 NCBI chr 8:59,273,860...59,426,486
Ensembl chr 8:59,275,569...59,430,348 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:22952941)		 Ensembl
Alzheimers_University_of_Toronto
RGD		 PMID:22952941 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Rhag Rh-associated glycoprotein involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5318589 (PMID:19807729)		 Ensembl
RGD		 PMID:19807729 GO_REF:0000107 NCBI chr 9:20,069,800...20,097,836
Ensembl chr 9:20,069,807...20,097,836 		JBrowse link
G Rhd Rh blood group, D antigen acts_upstream_of_or_within ISO MGI:5318588 (PMID:19807729) RGD PMID:19807729 NCBI chr 5:147,087,479...147,121,716
Ensembl chr 5:147,087,518...147,121,715 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857755|MGI:2446573 (PMID:19321419), (PMID:9824471)		 Ensembl
RGD		 PMID:9824471 PMID:19321419 GO_REF:0000107 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:15459009)
GO_REF:0000118
MGI:1856400 (PMID:18076961), (PMID:5070129)		 Ensembl
RGD
TreeGrafter		 PMID:5070129 PMID:15459009 PMID:18076961 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:3039043|PMID:15084469)
MGI:1889622 (PMID:15342464), (PMID:19596281)		 RGD PMID:15084469 PMID:15342464 PMID:19596281 MGI:3039043 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within ISO MGI:1857344 (PMID:15205258) RGD PMID:15205258 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tfr2 transferrin receptor 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:21173098)
MGI:2384726 (PMID:22960056)		 RGD PMID:21173098 PMID:22960056 NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591 		JBrowse link
G Tmprss6 transmembrane serine protease 6 involved_in
acts_upstream_of_or_within		 ISO (PMID:18408718)
MGI:3776631 (PMID:19751239)		 RGD PMID:18408718 PMID:19751239 NCBI chr 7:109,991,008...110,021,626
Ensembl chr 7:109,985,931...110,021,624 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    multicellular organismal process 8921
      multicellular organismal-level homeostasis 945
        multicellular organismal-level chemical homeostasis 81
          multicellular organismal-level iron ion homeostasis 30
Path 2
Term Annotations click to browse term
  biological_process 20413
    homeostatic process 1977
      chemical homeostasis 1211
        monoatomic ion homeostasis 678
          monoatomic cation homeostasis 664
            multicellular organismal-level iron ion homeostasis 30
paths to the root