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ONTOLOGY REPORT - ANNOTATIONS


Term:ventral spinal cord interneuron fate commitment
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Accession:GO:0060579 term browser browse the term
Definition:The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.


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ventral spinal cord interneuron fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL1 achaete-scute family bHLH transcription factor 1 ISO (MGI:3587461|PMID:16020526) UniProt PMID:16020526 MGI:3587461 NCBI chr 5:81,357,431...81,360,335 JBrowse link
G DLL4 delta like canonical Notch ligand 4 IEA Ensembl GO_REF:0000107 NCBI chr 1:130,376,720...130,386,411
Ensembl chr 1:130,376,720...130,386,713
JBrowse link
G FOXN4 forkhead box N4 ISO (MGI:3587461|PMID:16020526), (MGI:3765356|PMID:17728344) UniProt PMID:16020526 PMID:17728344 MGI:3587461 MGI:3765356 NCBI chr14:41,589,128...41,614,488 JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI2 GLI family zinc finger 2 IEA Ensembl GO_REF:0000107 NCBI chr15:30,312,528...30,580,272
Ensembl chr15:30,313,817...30,579,306
JBrowse link
G GLI3 GLI family zinc finger 3 IEA Ensembl GO_REF:0000107 NCBI chr18:52,403,463...52,697,906
Ensembl chr18:52,404,071...52,697,903
JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling IEA Ensembl GO_REF:0000107 NCBI chr14:113,500,001...113,628,064
Ensembl chr14:113,500,842...113,614,517
JBrowse link
ventral spinal cord interneuron fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr17:29,275,656...29,279,572
Ensembl chr17:29,275,682...29,278,606
JBrowse link
ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBX1 developing brain homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:39,229,392...39,234,304
Ensembl chr 2:39,229,356...39,234,969
JBrowse link
G DMRT3 doublesex and mab-3 related transcription factor 3 IEA Ensembl GO_REF:0000107 NCBI chr 1:220,819,525...220,834,080
Ensembl chr 1:220,820,556...220,833,835
JBrowse link
G LHX3 LIM homeobox 3 IEA Ensembl GO_REF:0000107
G SHH sonic hedgehog signaling molecule ISO PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,718...2,555,484
JBrowse link
G SOX1 SRY-box transcription factor 1 ISO (MGI:4834949|PMID:20844123) MGI PMID:20844123 MGI:4834949 NCBI chr11:77,985,771...77,989,383 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16530
    multicellular organismal process 8038
      pattern specification process 471
        cell fate commitment involved in pattern specification 12
          ventral spinal cord interneuron fate commitment 12
            ventral spinal cord interneuron fate determination 1
            ventral spinal cord interneuron specification + 8
Path 2
Term Annotations click to browse term
  biological_process 16530
    developmental process 6306
      anatomical structure development 5848
        multicellular organism development 5344
          system development 4966
            nervous system development 2595
              neurogenesis 1869
                generation of neurons 1721
                  neuron differentiation 1563
                    central nervous system neuron differentiation 241
                      ventral spinal cord interneuron differentiation 14
                        ventral spinal cord interneuron fate commitment 12
                          ventral spinal cord interneuron fate determination 1
                          ventral spinal cord interneuron specification + 8
paths to the root