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ONTOLOGY REPORT - ANNOTATIONS

Term:ventral spinal cord interneuron fate commitment
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Accession:GO:0060579 term browser browse the term
Definition:The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.

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ventral spinal cord interneuron fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL1 achaete-scute family bHLH transcription factor 1 ISS UniProtKB GO_REF:0000024 NCBI chr12:102,957,674...102,960,513
Ensembl chr12:102,957,674...102,960,513 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 IMP (PMID:17728344) UniProtKB PMID:17728344 NCBI chr15:40,929,340...40,939,073
Ensembl chr15:40,929,340...40,939,073 		JBrowse link
G FOXN4 forkhead box N4 ISS UniProtKB GO_REF:0000024 NCBI chr12:109,277,978...109,309,406
Ensembl chr12:109,277,978...109,309,284 		JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI2 GLI family zinc finger 2 ISS UniProtKB GO_REF:0000024 NCBI chr 2:120,735,868...120,992,653
Ensembl chr 2:120,735,623...120,992,653 		JBrowse link
G GLI3 GLI family zinc finger 3 IEA Ensembl GO_REF:0000107 NCBI chr 7:41,960,949...42,237,209
Ensembl chr 7:41,960,949...42,237,870
Ensembl chr 7:41,960,949...42,237,870 		JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling IEA Ensembl GO_REF:0000107 NCBI chr10:102,502,801...102,633,535
Ensembl chr10:102,503,987...102,633,535
Ensembl chr10:102,503,987...102,633,535 		JBrowse link
ventral spinal cord interneuron fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr20:21,511,010...21,514,064
Ensembl chr20:21,511,017...21,514,064 		JBrowse link
ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBX1 developing brain homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr11:20,156,155...20,160,475
Ensembl chr11:20,156,155...20,160,475 		JBrowse link
G DMRT3 doublesex and mab-3 related transcription factor 3 IEA Ensembl GO_REF:0000107 NCBI chr 9:976,655...991,732
Ensembl chr 9:976,655...991,732 		JBrowse link
G LHX3 LIM homeobox 3 IEA Ensembl GO_REF:0000107 NCBI chr 9:136,196,250...136,205,128
Ensembl chr 9:136,196,250...136,205,128 		JBrowse link
G SHH sonic hedgehog signaling molecule ISO PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G SOX1 SRY-box transcription factor 1 IEA Ensembl GO_REF:0000107 NCBI chr13:112,067,149...112,071,706
Ensembl chr13:112,067,149...112,071,706 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18678
    multicellular organismal process 8790
      pattern specification process 512
        cell fate commitment involved in pattern specification 12
          ventral spinal cord interneuron fate commitment 12
            ventral spinal cord interneuron fate determination 1
            ventral spinal cord interneuron specification + 8
Path 2
Term Annotations click to browse term
  biological_process 18678
    developmental process 7477
      anatomical structure development 6890
        multicellular organism development 6367
          system development 5770
            nervous system development 2896
              neurogenesis 1997
                generation of neurons 1852
                  neuron differentiation 1690
                    central nervous system neuron differentiation 250
                      ventral spinal cord interneuron differentiation 14
                        ventral spinal cord interneuron fate commitment 12
                          ventral spinal cord interneuron fate determination 1
                          ventral spinal cord interneuron specification + 8
paths to the root