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ONTOLOGY REPORT - ANNOTATIONS


Term:ventral spinal cord interneuron fate commitment
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Accession:GO:0060579 term browser browse the term
Definition:The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.


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ventral spinal cord interneuron fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL1 achaete-scute family bHLH transcription factor 1 IEA Ensembl GO_REF:0000107 NCBI chr15:41,694,021...41,696,933
Ensembl chr15:41,694,269...41,695,391
JBrowse link
G DLL4 delta like canonical Notch ligand 4 IEA Ensembl GO_REF:0000107 NCBI chr30:8,059,463...8,068,742
Ensembl chr30:8,059,512...8,067,940
JBrowse link
G FOXN4 forkhead box N4 IEA Ensembl GO_REF:0000107 NCBI chr26:17,730,638...17,757,173
Ensembl chr26:17,728,878...17,755,602
JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI2 GLI family zinc finger 2 IEA Ensembl GO_REF:0000107 NCBI chr19:29,128,401...29,383,324
Ensembl chr19:29,130,227...29,383,658
JBrowse link
G GLI3 GLI family zinc finger 3 IEA Ensembl GO_REF:0000107 NCBI chr18:7,800,817...8,071,531
Ensembl chr18:7,801,394...8,068,132
JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling IEA Ensembl GO_REF:0000107 NCBI chr28:14,992,989...15,115,499
Ensembl chr28:14,992,618...15,112,389
JBrowse link
ventral spinal cord interneuron fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NKX2-2 NK2 homeobox 2 IEA Ensembl GO_REF:0000107 NCBI chr24:1,933,176...1,935,875
Ensembl chr24:1,925,013...1,935,874
JBrowse link
ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBX1 developing brain homeobox 1 IEA Ensembl GO_REF:0000107 NCBI chr21:42,207,205...42,214,954
Ensembl chr21:42,208,346...42,212,415
JBrowse link
G DMRT3 doublesex and mab-3 related transcription factor 3 IEA Ensembl GO_REF:0000107 NCBI chr 1:89,798,215...89,813,140
Ensembl chr 1:89,798,100...89,812,328
JBrowse link
G LHX3 LIM homeobox 3 IEA Ensembl GO_REF:0000107 NCBI chr 9:49,248,555...49,254,128
Ensembl chr 9:49,248,621...49,254,118
JBrowse link
G SHH sonic hedgehog signaling molecule ISO PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chr16:18,650,553...18,663,571
Ensembl chr16:18,484,809...18,662,903
JBrowse link
G SOX1 SRY-box transcription factor 1 ISO (MGI:4834949|PMID:20844123) MGI PMID:20844123 MGI:4834949 NCBI chr22:59,902,113...59,903,820 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16106
    multicellular organismal process 7619
      pattern specification process 475
        cell fate commitment involved in pattern specification 12
          ventral spinal cord interneuron fate commitment 12
            ventral spinal cord interneuron fate determination 1
            ventral spinal cord interneuron specification + 8
Path 2
Term Annotations click to browse term
  biological_process 16106
    developmental process 6350
      anatomical structure development 5897
        multicellular organism development 5388
          system development 5026
            nervous system development 2609
              neurogenesis 1877
                generation of neurons 1728
                  neuron differentiation 1573
                    central nervous system neuron differentiation 239
                      ventral spinal cord interneuron differentiation 14
                        ventral spinal cord interneuron fate commitment 12
                          ventral spinal cord interneuron fate determination 1
                          ventral spinal cord interneuron specification + 8
paths to the root