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ONTOLOGY REPORT - ANNOTATIONS


Term:ventral spinal cord interneuron fate commitment
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Accession:GO:0060579 term browser browse the term
Definition:The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.


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ventral spinal cord interneuron fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 ISO (MGI:3587461|PMID:16020526) UniProt PMID:16020526 MGI:3587461 NCBI chrNW_004955405:37,941,243...37,943,641
Ensembl chrNW_004955405:37,941,243...37,943,641
JBrowse link
G Dll4 delta like canonical Notch ligand 4 ISO (PMID:17728344) UniProtKB PMID:17728344 NCBI chrNW_004955416:7,807,049...7,816,346
Ensembl chrNW_004955416:7,807,049...7,817,420
JBrowse link
G Foxn4 forkhead box N4 ISO (MGI:3587461|PMID:16020526), (MGI:3765356|PMID:17728344) UniProt PMID:16020526 PMID:17728344 MGI:3587461 MGI:3765356 NCBI chrNW_004955455:9,182,405...9,210,365
Ensembl chrNW_004955455:9,183,475...9,210,506
JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chrNW_004955459:8,892,917...9,124,672
Ensembl chrNW_004955459:8,892,869...9,118,499
JBrowse link
G Gli3 GLI family zinc finger 3 ISO (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chrNW_004955460:1,528,457...1,805,584
Ensembl chrNW_004955460:1,528,412...1,805,918
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chrNW_004955485:7,805,244...7,925,414
Ensembl chrNW_004955485:7,808,131...7,925,677
JBrowse link
ventral spinal cord interneuron fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-2 NK2 homeobox 2 ISO (MGI:1334824|PMID:10217145) MGI PMID:10217145 MGI:1334824 NCBI chrNW_004955415:29,263,741...29,268,259
Ensembl chrNW_004955415:29,258,434...29,268,259
JBrowse link
ventral spinal cord interneuron specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbx1 developing brain homeobox 1 ISO (MGI:2136554|PMID:11239429) MGI PMID:11239429 MGI:2136554 NCBI chrNW_004955476:1,018,715...1,022,648
Ensembl chrNW_004955476:1,018,715...1,022,545
JBrowse link
G Dmrt3 doublesex and mab-3 related transcription factor 3 ISO (MGI:5435948|PMID:22932389) MGI PMID:22932389 MGI:5435948 NCBI chrNW_004955434:5,455,449...5,470,343
Ensembl chrNW_004955434:5,455,449...5,470,343
JBrowse link
G Lhx3 LIM homeobox 3 ISO (MGI:4356383|PMID:19666821) MGI PMID:19666821 MGI:4356383 NCBI chrNW_004955513:4,464,149...4,470,962
Ensembl chrNW_004955513:4,464,149...4,470,962
JBrowse link
G Shh sonic hedgehog signaling molecule ISO PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chrNW_004955491:8,647,133...8,657,381 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11920
    multicellular organismal process 6178
      pattern specification process 438
        cell fate commitment involved in pattern specification 11
          ventral spinal cord interneuron fate commitment 11
            ventral spinal cord interneuron fate determination 1
            ventral spinal cord interneuron specification + 7
Path 2
Term Annotations click to browse term
  biological_process 11920
    developmental process 5631
      anatomical structure development 5267
        multicellular organism development 4825
          system development 4545
            nervous system development 2354
              neurogenesis 1693
                generation of neurons 1557
                  neuron differentiation 1409
                    central nervous system neuron differentiation 225
                      ventral spinal cord interneuron differentiation 13
                        ventral spinal cord interneuron fate commitment 11
                          ventral spinal cord interneuron fate determination 1
                          ventral spinal cord interneuron specification + 7
paths to the root