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ONTOLOGY REPORT - ANNOTATIONS

Term:ventral spinal cord interneuron fate commitment
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Accession:GO:0060579 term browser browse the term
Definition:The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses.


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ventral spinal cord interneuron fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16020526)		 UniProt
RGD		 PMID:16020526 GO_REF:0000024 NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 involved_in ISO
IEA		 UniProtKB:Q8K3Q3 (PMID:17728344)
GO_REF:0000107		 RGD
Ensembl		 PMID:17728344 GO_REF:0000107 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Foxn4 forkhead box N4 involved_in ISO (PMID:16020526), (PMID:17728344) RGD PMID:16020526 PMID:17728344 NCBI chr12:42,336,706...42,359,932
Ensembl chr12:42,340,323...42,359,921 		JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 acts_upstream_of_or_within ISO MGI:95729 (PMID:15215207) RGD PMID:15215207 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 acts_upstream_of_or_within ISO MGI:95728 (PMID:15215207) RGD PMID:15215207 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling acts_upstream_of_or_within ISO MGI:4840420 (PMID:19684112) RGD PMID:19684112 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577 		JBrowse link
ventral spinal cord interneuron fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within ISO MGI:1932100 (PMID:10217145) RGD PMID:10217145 NCBI chr 3:134,619,701...134,630,282
Ensembl chr 3:134,620,039...134,622,411 		JBrowse link
ventral spinal cord interneuron specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbx1 developing brain homeobox 1 acts_upstream_of_or_within ISO MGI:2182329 (PMID:11239429) RGD PMID:11239429 NCBI chr 1:99,348,638...99,354,173
Ensembl chr 1:99,349,608...99,354,038 		JBrowse link
G Dmrt3 doublesex and mab-3 related transcription factor 3 acts_upstream_of_or_within ISO MGI:4420993 (PMID:22932389) RGD PMID:22932389 NCBI chr 1:223,244,340...223,264,254
Ensembl chr 1:223,248,747...223,262,530 		JBrowse link
G Lhx3 LIM homeobox 3 acts_upstream_of_or_within ISO (PMID:19666821) RGD PMID:19666821 NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480 		JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within IDA PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Sox1 SRY-box transcription factor 1 acts_upstream_of_or_within ISO MGI:3653406 (PMID:20844123) RGD PMID:20844123 NCBI chr16:77,135,577...77,139,592
Ensembl chr16:77,137,584...77,138,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    multicellular organismal process 8906
      pattern specification process 500
        cell fate commitment involved in pattern specification 12
          ventral spinal cord interneuron fate commitment 12
            ventral spinal cord interneuron fate determination 1
            ventral spinal cord interneuron specification + 8
Path 2
Term Annotations click to browse term
  biological_process 20076
    developmental process 7070
      anatomical structure development 6573
        multicellular organism development 5299
          system development 4584
            nervous system development 2848
              neurogenesis 2111
                generation of neurons 1807
                  neuron differentiation 1722
                    central nervous system neuron differentiation 254
                      ventral spinal cord interneuron differentiation 14
                        ventral spinal cord interneuron fate commitment 12
                          ventral spinal cord interneuron fate determination 1
                          ventral spinal cord interneuron specification + 8
paths to the root