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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of necrotic cell death
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Accession:GO:0060547 term browser browse the term
Definition:Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.


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negative regulation of necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor involved_in ISO (MGI:3794480|PMID:16443691) RGD PMID:16443691 MGI:3794480 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 IMP RGD PMID:23409069 RGD:150517731 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Fth1 ferritin heavy chain 1 IMP RGD PMID:18992754 RGD:2315110 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Mt3 metallothionein 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18554677)
(MGI:5315682|PMID:20371971)		 UniProt
RGD		 PMID:18554677 PMID:20371971 GO_REF:0000024 MGI:5315682 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 IMP RGD PMID:26888427 RGD:11040458 NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189 		JBrowse link
G Nol3 nucleolar protein 3 involved_in ISO
IEA		 (MGI:5617337|PMID:24440909)
GO_REF:0000107		 RGD
Ensembl		 PMID:24440909 GO_REF:0000107 MGI:5617337 NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250 		JBrowse link
G Ucn urocortin IDA RGD PMID:20933497 RGD:5508190 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950 		JBrowse link
negative regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adprs ADP-ribosylserine hydrolase involved_in ISO (MGI:6445044|PMID:30830864) RGD PMID:30830864 MGI:6445044 NCBI chr 5:138,614,022...138,619,296
Ensembl chr 5:138,614,022...138,619,296 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:22711822) RGD PMID:22711822 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:104798 (MGI:5315337|PMID:21052097)		 RGD PMID:21052097 PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 involved_in IBA
ISO		 PMID:21873635
(MGI:5315337|PMID:21052097)		 RGD PMID:21052097 PMID:21873635 MGI:5315337, RGD:13792537 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:5796062 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Casp2 caspase 2 involved_in ISO (PMID:30025878) RGD PMID:30025878 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp8 caspase 8 involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:31827280)
MGI:104798|MGI:1336166|MGI:1921506|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5294742|PMID:21402742), (MGI:5306844|PMID:22037414), (MGI:5521568|PMID:22089168)
(MGI:6378798|PMID:31511692), (MGI:6401035|PMID:31748744), (MGI:6401044|PMID:31827281)
GO_REF:0000024		 RGD
UniProt		 PMID:21368763 PMID:21402742 PMID:22037414 PMID:22089168 PMID:31511692 More... GO_REF:0000024 MGI:4947443 MGI:5294742 MGI:5306844 MGI:5521568 MGI:6378798 MGI:6401035 MGI:6401044 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cav1 caveolin 1 involved_in ISO (MGI:5464050|PMID:23049990) RGD PMID:23049990 MGI:5464050 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator acts_upstream_of_or_within ISO MGI:104798|MGI:1261423|MGI:2154952 (MGI:4947443|PMID:21368763), (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168) RGD PMID:21368763 PMID:22089168 PMID:22675671 MGI:4947443 MGI:5486419 MGI:5521568 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Fadd Fas associated via death domain acts_upstream_of_or_within ISO MGI:104798|MGI:2154952 (MGI:5486419|PMID:22675671), (MGI:5521568|PMID:22089168) RGD PMID:22089168 PMID:22675671 MGI:5486419 MGI:5521568 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO (MGI:5315337|PMID:21052097) RGD PMID:21052097 MGI:5315337 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mir101-2 microRNA 101-2 involved_in ISO (PMID:25910754) RGD PMID:25910754 NCBI chr 1:226,860,371...226,860,467
Ensembl chr 1:226,860,371...226,860,467 		JBrowse link
G Mir101a microRNA 101a involved_in ISO (PMID:25910754) RGD PMID:25910754 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410 		JBrowse link
G Mir214 microRNA 214 involved_in ISO (PMID:25910754) RGD PMID:25910754 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir22 microRNA 22 involved_in ISO (PMID:25910754) RGD PMID:25910754 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133 		JBrowse link
G Mir221 microRNA 221 involved_in ISO (PMID:25910754) RGD PMID:25910754 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mutyh mutY DNA glycosylase involved_in ISO
IEA		 (MGI:6378777|PMID:28059467)
GO_REF:0000107		 RGD
Ensembl		 PMID:28059467 GO_REF:0000107 MGI:6378777 NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 involved_in ISO (MGI:6163945|PMID:29883609)
(PMID:29883609)		 RGD PMID:29883609 MGI:6163945 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:104798 (MGI:5521568|PMID:22089168)
GO_REF:0000107		 RGD
Ensembl		 PMID:22089168 GO_REF:0000107 MGI:5521568 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (MGI:5602910|PMID:24813850), (MGI:5602911|PMID:24813849), (MGI:5907398|PMID:27819682), (MGI:5907399|PMID:27819681) RGD PMID:24813849 PMID:24813850 PMID:27819681 PMID:27819682 MGI:5602910 MGI:5602911 MGI:5907398 MGI:5907399 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Rnf31 ring finger protein 31 acts_upstream_of_or_within ISO MGI:104798 (MGI:5521568|PMID:22089168) RGD PMID:22089168 MGI:5521568 NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16507998)		 Ensembl
RGD		 PMID:16507998 GO_REF:0000107 NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733 		JBrowse link
G Ybx3 Y box binding protein 3 involved_in ISO
IEA		 (PMID:22711822)
GO_REF:0000107		 RGD
Ensembl		 PMID:22711822 GO_REF:0000107 NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161 		JBrowse link
negative regulation of programmed necrotic cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISO
ISS		 (PMID:30451898)
GO_REF:0000024		 RGD
UniProt		 PMID:30451898 GO_REF:0000024 NCBI chr 1:181,213,292...181,215,327 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    cellular process 18159
      negative regulation of cellular process 5100
        negative regulation of cell death 1175
          negative regulation of necrotic cell death 31
            negative regulation of programmed necrotic cell death + 24
Path 2
Term Annotations click to browse term
  biological_process 19746
    biological regulation 13447
      regulation of biological process 13040
        regulation of cellular process 12250
          regulation of cell death 1878
            negative regulation of cell death 1175
              negative regulation of necrotic cell death 31
                negative regulation of programmed necrotic cell death + 24
paths to the root