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ONTOLOGY REPORT - ANNOTATIONS

Term:epithelial tube branching involved in lung morphogenesis
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Accession:GO:0060441 term browser browse the term
Definition:The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
Synonyms:exact_synonym: lung branching morphogenesis

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epithelial tube branching involved in lung morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEP
ISO		 (PMID:8674409) RGD PMID:8674409, PMID:8769111 RGD:2306315 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2148567 (MGI:3773938|PMID:18231602)		 Ensembl
RGD		 PMID:18231602 GO_REF:0000107 MGI:3773938 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Ctsd cathepsin D NOT|involved_in ISO (MGI:3722010|PMID:17500053) RGD PMID:17500053 MGI:3722010 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Ctsl cathepsin L NOT|involved_in ISO (MGI:3722010|PMID:17500053) RGD PMID:17500053 MGI:3722010 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279 		JBrowse link
G Ctsz cathepsin Z acts_upstream_of_or_within ISO (PMID:17500053) RGD PMID:17500053 NCBI chr 3:172,527,107...172,537,877
Ensembl chr 3:172,527,107...172,537,877 		JBrowse link
G Dag1 dystroglycan 1 acts_upstream_of_or_within ISO (MGI:2156962|PMID:11798066) RGD PMID:11798066 MGI:2156962 NCBI chr 8:116,980,501...116,993,182
Ensembl chr 8:116,980,497...116,993,193 		JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 acts_upstream_of_or_within ISO MGI:3757646 (MGI:5487693|PMID:23466739) RGD PMID:23466739 MGI:5487693 NCBI chr15:120,213...230,312
Ensembl chr15:120,372...228,977 		JBrowse link
G Esrp1 epithelial splicing regulatory protein 1 acts_upstream_of_or_within ISO MGI:1924661 (MGI:5699497|PMID:26371508) RGD PMID:26371508 MGI:5699497 NCBI chr 5:24,576,988...24,631,758
Ensembl chr 5:24,576,991...24,631,698 		JBrowse link
G Esrp2 epithelial splicing regulatory protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1917326 (MGI:5699497|PMID:26371508)		 Ensembl
RGD		 PMID:26371508 GO_REF:0000107 MGI:5699497 NCBI chr19:38,113,412...38,120,578
Ensembl chr19:38,113,412...38,120,578 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:5912649|PMID:28859094) RGD PMID:28859094 MGI:5912649 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068 		JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1859647|MGI:1927833|MGI:3629660 (MGI:1101385|PMID:9428423), (MGI:1309706|PMID:9784490), (MGI:1327513|PMID:9916808), (MGI:3578606|PMID:15800000), (MGI:3609523|PMID:16169547), (MGI:3613102|PMID:16375885), (MGI:3716020|PMID:17560563) RGD PMID:9428423 PMID:9784490 PMID:9916808 PMID:15800000 PMID:16169547 PMID:16375885 PMID:17560563 MGI:1101385 MGI:1309706 MGI:1327513 MGI:3578606 MGI:3609523 MGI:3613102 MGI:3716020 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:3044679 (MGI:5523405|PMID:24058167) RGD PMID:24058167 MGI:5523405 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928 		JBrowse link
G Foxa1 forkhead box A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1347476 (MGI:3579763|PMID:15668254)		 Ensembl
RGD		 PMID:15668254 GO_REF:0000107 MGI:3579763 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669 		JBrowse link
G Foxa2 forkhead box A2 acts_upstream_of_or_within ISO MGI:1347472 (MGI:3579763|PMID:15668254) RGD PMID:15668254 MGI:3579763 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481 		JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO MGI:1929432 (MGI:2135612|PMID:11493558) RGD PMID:11493558 MGI:2135612 NCBI chr19:53,012,306...53,016,100
Ensembl chr19:53,012,332...53,016,086 		JBrowse link
G Hhip Hedgehog-interacting protein acts_upstream_of_or_within ISO MGI:2450891 (MGI:2450020|PMID:12569124) RGD PMID:12569124 MGI:2450020 NCBI chr19:31,525,134...31,614,487
Ensembl chr19:31,524,671...31,614,246 		JBrowse link
G Hmga2 high mobility group AT-hook 2 acts_upstream_of_or_within ISO (MGI:5638831|PMID:24661562) RGD PMID:24661562 MGI:5638831 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408 		JBrowse link
G Hoxa5 homeo box A5 acts_upstream_of_or_within ISO MGI:2150397 (MGI:1195049|PMID:9441679) RGD PMID:9441679 MGI:1195049 NCBI chr 4:82,170,383...82,174,788
Ensembl chr 4:82,170,387...82,173,207 		JBrowse link
G Kras KRAS proto-oncogene, GTPase acts_upstream_of_or_within ISO MGI:98371 (MGI:5523405|PMID:24058167) RGD PMID:24058167 MGI:5523405 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558 		JBrowse link
G Lama1 laminin subunit alpha 1 acts_upstream_of_or_within ISO (MGI:2156962|PMID:11798066), (MGI:80991|PMID:1907584) RGD PMID:1907584 PMID:11798066 MGI:2156962 MGI:80991 NCBI chr 9:115,916,907...116,042,123
Ensembl chr 9:115,916,907...116,042,123 		JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in ISO
IEA		 (PMID:8675988)
GO_REF:0000107		 RGD
Ensembl		 PMID:8675988 GO_REF:0000107 NCBI chr 6:77,418,096...77,423,383
Ensembl chr 6:77,418,096...77,421,286 		JBrowse link
G Rspo2 R-spondin 2 acts_upstream_of_or_within ISO MGI:3045965 (MGI:3774879|PMID:18256198) RGD PMID:18256198 MGI:3774879 NCBI chr 7:81,919,911...82,059,659
Ensembl chr 7:81,924,050...82,059,789 		JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within IEP
ISO		 MGI:1857796 (MGI:1277744|PMID:9731532), (MGI:1346236|PMID:10500184) RGD PMID:9731532 PMID:10500184, PMID:8769111 MGI:1277744 MGI:1346236, RGD:2306315 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691 		JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (MGI:3795352|PMID:18374910) RGD PMID:18374910 MGI:3795352 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545 		JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO MGI:2385468|MGI:96680 (MGI:5523405|PMID:24058167) RGD PMID:24058167 MGI:5523405 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379 		JBrowse link
bud dilation involved in lung branching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO
IEA		 (PMID:8674409)
GO_REF:0000107		 RGD
Ensembl		 PMID:8674409 GO_REF:0000107 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
bud elongation involved in lung branching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3788965|PMID:18367557)		 Ensembl
RGD		 PMID:18367557 GO_REF:0000107 MGI:3788965 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1345138|MGI:1345139 (MGI:5052190|PMID:21764747) RGD PMID:21764747 MGI:5052190 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:3629660 (MGI:3688953|PMID:16989802) RGD PMID:16989802 MGI:3688953 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928 		JBrowse link
G Rdh10 retinol dehydrogenase 10 acts_upstream_of_or_within ISO (MGI:3709664|PMID:17473173) RGD PMID:17473173 MGI:3709664 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO MGI:1099809|MGI:1345138 (MGI:5052190|PMID:21764747) RGD PMID:21764747 MGI:5052190 NCBI chr 2:124,400,689...124,405,331
Ensembl chr 2:124,400,679...124,405,331 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO MGI:1099809|MGI:1345139 (MGI:5052190|PMID:21764747) RGD PMID:21764747 MGI:5052190 NCBI chr15:90,172,769...90,177,823
Ensembl chr15:90,172,975...90,175,802 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator acts_upstream_of_or_within ISO MGI:3053959|MGI:5316446 (MGI:5586932|PMID:25043473) RGD PMID:25043473 MGI:5586932 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579 		JBrowse link
bud outgrowth involved in lung branching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 involved_in ISO (PMID:9740653) RGD PMID:9740653 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857796 (MGI:1277744|PMID:9731532)		 Ensembl
RGD		 PMID:9731532 GO_REF:0000107 MGI:1277744 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691 		JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 acts_upstream_of_or_within ISO MGI:4124060 (MGI:5300435|PMID:21956870) RGD PMID:21956870 MGI:5300435 NCBI chr 7:40,171,957...40,217,056
Ensembl chr 7:40,171,963...40,217,056 		JBrowse link
G Tnc tenascin C IMP RGD PMID:16928692 RGD:4889612 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671 		JBrowse link
dichotomous subdivision of terminal units involved in lung branching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsh cathepsin H involved_in ISS
ISO		 GO_REF:0000024
(MGI:3722010|PMID:17500053)		 UniProt
RGD		 PMID:17500053 GO_REF:0000024 MGI:3722010 NCBI chr 8:97,439,155...97,458,293
Ensembl chr 8:97,439,161...97,458,287 		JBrowse link
lateral sprouting involved in lung morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 acts_upstream_of_or_within ISO MGI:2668337 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr 7:126,774,010...126,914,085
Ensembl chr 7:126,775,516...126,913,585 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:1857642 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr13:90,379,203...90,405,627
Ensembl chr13:90,380,632...90,405,591 		JBrowse link
lung induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2148567|MGI:2148569 (MGI:4360856|PMID:19686689), (MGI:4361775|PMID:19805295)		 Ensembl
RGD		 PMID:19686689 PMID:19805295 GO_REF:0000107 MGI:4360856 MGI:4361775 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Wnt2 Wnt family member 2 acts_upstream_of_or_within ISO MGI:1261834 (MGI:4360856|PMID:19686689) RGD PMID:19686689 MGI:4360856 NCBI chr 4:45,286,845...45,332,899
Ensembl chr 4:45,292,437...45,332,420 		JBrowse link
G Wnt2b Wnt family member 2B acts_upstream_of_or_within ISO MGI:98954 (MGI:4360856|PMID:19686689) RGD PMID:19686689 MGI:4360856 NCBI chr 2:207,433,771...207,457,094
Ensembl chr 2:207,440,886...207,455,258 		JBrowse link
negative regulation of branching involved in lung morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor involved_in ISO (PMID:17350185) RGD PMID:17350185 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 acts_upstream_of_or_within ISO MGI:2668337 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr 7:126,774,010...126,914,085
Ensembl chr 7:126,775,516...126,913,585 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:1857642 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr13:90,379,203...90,405,627
Ensembl chr13:90,380,632...90,405,591 		JBrowse link
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 acts_upstream_of_or_within ISO MGI:2668337 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr 7:126,774,010...126,914,085
Ensembl chr 7:126,775,516...126,913,585 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:1857642 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr13:90,379,203...90,405,627
Ensembl chr13:90,380,632...90,405,591 		JBrowse link
positive regulation of branching involved in lung morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:4456940|PMID:17350185)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17350185 GO_REF:0000024 GO_REF:0000107 MGI:4456940 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2148567 (MGI:3801531|PMID:18533146)		 Ensembl
RGD		 PMID:18533146 GO_REF:0000107 MGI:3801531 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IMP RGD PMID:8879189 RGD:11087558 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031 		JBrowse link
primary lung bud formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hhex hematopoietically expressed homeobox acts_upstream_of_or_within ISO MGI:2177762 (MGI:3703395|PMID:16364283) RGD PMID:16364283 MGI:3703395 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649 		JBrowse link
G Rdh10 retinol dehydrogenase 10 acts_upstream_of_or_within ISO (MGI:3709664|PMID:17473173) RGD PMID:17473173 MGI:3709664 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030 		JBrowse link
regulation of branching involved in lung morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO (MGI:5523731|PMID:24191021) RGD PMID:24191021 MGI:5523731 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    multicellular organismal process 8913
      morphogenesis of a branching structure 250
        morphogenesis of a branching epithelium 231
          branching morphogenesis of an epithelial tube 194
            epithelial tube branching involved in lung morphogenesis 39
              bud dilation involved in lung branching + 1
              bud elongation involved in lung branching 7
              bud outgrowth involved in lung branching + 4
              dichotomous subdivision of terminal units involved in lung branching + 3
              lateral sprouting involved in lung morphogenesis 2
              negative regulation of branching involved in lung morphogenesis + 1
              positive regulation of branching involved in lung morphogenesis + 3
              primary lung bud formation + 5
              regulation of branching involved in lung morphogenesis + 7
Path 2
Term Annotations click to browse term
  biological_process 19634
    developmental process 6783
      anatomical structure development 6259
        multicellular organism development 5741
          system development 5284
            animal organ development 4050
              respiratory tube development 266
                lung development 263
                  lung morphogenesis 71
                    epithelial tube branching involved in lung morphogenesis 39
                      bud dilation involved in lung branching + 1
                      bud elongation involved in lung branching 7
                      bud outgrowth involved in lung branching + 4
                      dichotomous subdivision of terminal units involved in lung branching + 3
                      lateral sprouting involved in lung morphogenesis 2
                      negative regulation of branching involved in lung morphogenesis + 1
                      positive regulation of branching involved in lung morphogenesis + 3
                      primary lung bud formation + 5
                      regulation of branching involved in lung morphogenesis + 7
paths to the root