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ONTOLOGY REPORT - ANNOTATIONS

Term:epithelial tube branching involved in lung morphogenesis
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Accession:GO:0060441 term browser browse the term
Definition:The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
Synonyms:exact_synonym: lung branching morphogenesis


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epithelial tube branching involved in lung morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within IEP
ISO		 (PMID:8674409) RGD PMID:8674409 PMID:8769111 RGD:2306315 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO MGI:2148567 (MGI:3773938|PMID:18231602)
MGI:2148567 (MGI:3801531|PMID:18533146)		 RGD PMID:18231602 PMID:18533146 MGI:3773938 MGI:3801531 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsd cathepsin D NOT|involved_in ISO (MGI:3722010|PMID:17500053) RGD PMID:17500053 MGI:3722010 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctsl cathepsin L NOT|involved_in ISO (MGI:3722010|PMID:17500053) RGD PMID:17500053 MGI:3722010 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Ctsz cathepsin Z acts_upstream_of_or_within ISO (PMID:17500053) RGD PMID:17500053 NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645 		JBrowse link
G Dag1 dystroglycan 1 acts_upstream_of_or_within ISO (MGI:2156962|PMID:11798066) RGD PMID:11798066 MGI:2156962 NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325 		JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 acts_upstream_of_or_within ISO MGI:3757646 (MGI:5487693|PMID:23466739) RGD PMID:23466739 MGI:5487693 NCBI chr15:75,786...209,735
Ensembl chr15:75,786...187,837 		JBrowse link
G Esrp1 epithelial splicing regulatory protein 1 acts_upstream_of_or_within ISO MGI:1924661 (MGI:5699497|PMID:26371508) RGD PMID:26371508 MGI:5699497 NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062 		JBrowse link
G Esrp2 epithelial splicing regulatory protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1917326 (MGI:5699497|PMID:26371508)		 Ensembl
RGD		 PMID:26371508 GO_REF:0000107 MGI:5699497 NCBI chr19:34,034,559...34,041,726
Ensembl chr19:34,034,559...34,041,726 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:5912649|PMID:28859094) RGD PMID:28859094 MGI:5912649 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357 		JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1859647|MGI:1927833|MGI:3629660 (MGI:1101385|PMID:9428423), (MGI:1309706|PMID:9784490), (MGI:1327513|PMID:9916808), (MGI:3578606|PMID:15800000), (MGI:3609523|PMID:16169547), (MGI:3613102|PMID:16375885), (MGI:3716020|PMID:17560563) RGD PMID:9428423 PMID:9784490 PMID:9916808 PMID:15800000 PMID:16169547 More... MGI:1101385 MGI:1309706 MGI:1327513 MGI:3578606 MGI:3609523 MGI:3613102 MGI:3716020 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:3044679 (MGI:5523405|PMID:24058167) RGD PMID:24058167 MGI:5523405 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Foxa1 forkhead box A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1347476 (MGI:3579763|PMID:15668254)		 Ensembl
RGD		 PMID:15668254 GO_REF:0000107 MGI:3579763 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Foxa2 forkhead box A2 acts_upstream_of_or_within ISO MGI:1347472 (MGI:3579763|PMID:15668254) RGD PMID:15668254 MGI:3579763 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326 		JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO MGI:1929432 (MGI:2135612|PMID:11493558) RGD PMID:11493558 MGI:2135612 NCBI chr19:49,153,729...49,157,741
Ensembl chr19:49,153,699...49,157,738 		JBrowse link
G Hhip Hedgehog-interacting protein acts_upstream_of_or_within ISO MGI:2450891 (MGI:2450020|PMID:12569124) RGD PMID:12569124 MGI:2450020 NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528 		JBrowse link
G Hmga2 high mobility group AT-hook 2 acts_upstream_of_or_within ISO (MGI:5638831|PMID:24661562) RGD PMID:24661562 MGI:5638831 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784 		JBrowse link
G Hoxa5 homeo box A5 acts_upstream_of_or_within ISO MGI:2150397 (MGI:1195049|PMID:9441679) RGD PMID:9441679 MGI:1195049 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234 		JBrowse link
G Kras KRAS proto-oncogene, GTPase acts_upstream_of_or_within ISO MGI:98371 (MGI:5523405|PMID:24058167) RGD PMID:24058167 MGI:5523405 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lama1 laminin subunit alpha 1 acts_upstream_of_or_within ISO (MGI:2156962|PMID:11798066), (MGI:80991|PMID:1907584) RGD PMID:1907584 PMID:11798066 MGI:2156962 MGI:80991 NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478 		JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in ISO
IEA		 (PMID:8675988)
GO_REF:0000107		 RGD
Ensembl		 PMID:8675988 GO_REF:0000107 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Rspo2 R-spondin 2 acts_upstream_of_or_within ISO MGI:3045965 (MGI:3774879|PMID:18256198) RGD PMID:18256198 MGI:3774879 NCBI chr 7:74,096,378...74,239,398
Ensembl chr 7:74,103,090...74,238,933 		JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within IEP
ISO		 MGI:1857796 (MGI:1277744|PMID:9731532), (MGI:1346236|PMID:10500184) RGD PMID:9731532 PMID:10500184 PMID:8769111 MGI:1277744 MGI:1346236, RGD:2306315 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Sox2 SRY-box transcription factor 2 acts_upstream_of_or_within ISO (MGI:3795352|PMID:18374910) RGD PMID:18374910 MGI:3795352 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO MGI:2385468|MGI:96680 (MGI:5523405|PMID:24058167) RGD PMID:24058167 MGI:5523405 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Tbx2 T-box transcription factor 2 involved_in ISO UniProtKB:P70324 (MGI:5805984|PMID:27720610) RGD PMID:27720610 MGI:5805984 NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529 		JBrowse link
bud dilation involved in lung branching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:8674409)
GO_REF:0000107		 RGD
Ensembl		 PMID:8674409 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
bud elongation involved in lung branching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3788965|PMID:18367557)		 Ensembl
RGD		 PMID:18367557 GO_REF:0000107 MGI:3788965 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1345138|MGI:1345139 (MGI:5052190|PMID:21764747) RGD PMID:21764747 MGI:5052190 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:3629660 (MGI:3688953|PMID:16989802) RGD PMID:16989802 MGI:3688953 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Rdh10 retinol dehydrogenase 10 acts_upstream_of_or_within ISO (MGI:3709664|PMID:17473173) RGD PMID:17473173 MGI:3709664 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO MGI:1099809|MGI:1345138 (MGI:5052190|PMID:21764747) RGD PMID:21764747 MGI:5052190 NCBI chr 2:120,557,276...120,561,918
Ensembl chr 2:120,556,706...120,566,189 		JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO MGI:1099809|MGI:1345139 (MGI:5052190|PMID:21764747) RGD PMID:21764747 MGI:5052190 NCBI chr15:82,692,312...82,697,408
Ensembl chr15:82,692,143...82,698,009 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator acts_upstream_of_or_within ISO MGI:3053959|MGI:5316446 (MGI:5586932|PMID:25043473) RGD PMID:25043473 MGI:5586932 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
bud outgrowth involved in lung branching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO (PMID:9740653) RGD PMID:9740653 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857796 (MGI:1277744|PMID:9731532)		 Ensembl
RGD		 PMID:9731532 GO_REF:0000107 MGI:1277744 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 acts_upstream_of_or_within ISO MGI:4124060 (MGI:5300435|PMID:21956870) RGD PMID:21956870 MGI:5300435 NCBI chr 7:35,264,886...35,310,010
Ensembl chr 7:35,264,892...35,310,385 		JBrowse link
G Tnc tenascin C IMP RGD PMID:16928692 RGD:4889612 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
dichotomous subdivision of terminal units involved in lung branching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsh cathepsin H involved_in ISS
ISO		 GO_REF:0000024
(MGI:3722010|PMID:17500053)		 UniProt
RGD		 PMID:17500053 GO_REF:0000024 MGI:3722010 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824 		JBrowse link
lateral sprouting involved in lung morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 acts_upstream_of_or_within ISO MGI:2668337 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:1857642 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378 		JBrowse link
lung induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO MGI:2148567|MGI:2148569 (MGI:4360856|PMID:19686689), (MGI:4361775|PMID:19805295) RGD PMID:19686689 PMID:19805295 MGI:4360856 MGI:4361775 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Wnt2 Wnt family member 2 acts_upstream_of_or_within ISO MGI:1261834 (MGI:4360856|PMID:19686689) RGD PMID:19686689 MGI:4360856 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402 		JBrowse link
G Wnt2b Wnt family member 2B acts_upstream_of_or_within ISO MGI:98954 (MGI:4360856|PMID:19686689) RGD PMID:19686689 MGI:4360856 NCBI chr 2:192,454,226...192,468,599
Ensembl chr 2:192,453,824...192,470,308 		JBrowse link
negative regulation of branching involved in lung morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor involved_in ISO (PMID:17350185) RGD PMID:17350185 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 acts_upstream_of_or_within ISO MGI:2668337 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:1857642 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378 		JBrowse link
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 acts_upstream_of_or_within ISO MGI:2668337 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164 		JBrowse link
G Vangl2 VANGL planar cell polarity protein 2 acts_upstream_of_or_within ISO MGI:1857642 (MGI:4452277|PMID:20223754) RGD PMID:20223754 MGI:4452277 NCBI chr13:84,462,731...84,489,404
Ensembl chr13:84,465,527...84,489,378 		JBrowse link
positive regulation of branching involved in lung morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(MGI:4456940|PMID:17350185)		 Ensembl
UniProt
RGD		 PMID:17350185 GO_REF:0000024 GO_REF:0000107 MGI:4456940 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO MGI:2148567 (MGI:3801531|PMID:18533146) RGD PMID:18533146 MGI:3801531 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IMP RGD PMID:8879189 RGD:11087558 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
primary lung bud formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hhex hematopoietically expressed homeobox acts_upstream_of_or_within ISO MGI:2177762 (MGI:3703395|PMID:16364283) RGD PMID:16364283 MGI:3703395 NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042 		JBrowse link
G Rdh10 retinol dehydrogenase 10 acts_upstream_of_or_within ISO (MGI:3709664|PMID:17473173) RGD PMID:17473173 MGI:3709664 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
regulation of branching involved in lung morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO (MGI:5523731|PMID:24191021) RGD PMID:24191021 MGI:5523731 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    developmental process 6926
      anatomical structure morphogenesis 2992
        animal organ morphogenesis 1181
          lung morphogenesis 72
            epithelial tube branching involved in lung morphogenesis 40
              bud dilation involved in lung branching + 1
              bud elongation involved in lung branching 7
              bud outgrowth involved in lung branching + 4
              dichotomous subdivision of terminal units involved in lung branching + 3
              lateral sprouting involved in lung morphogenesis 2
              negative regulation of branching involved in lung morphogenesis + 1
              positive regulation of branching involved in lung morphogenesis + 3
              primary lung bud formation + 5
              regulation of branching involved in lung morphogenesis + 7
Path 2
Term Annotations click to browse term
  biological_process 18877
    developmental process 6926
      anatomical structure development 6400
        tissue development 2189
          tissue morphogenesis 722
            morphogenesis of an epithelium 601
              morphogenesis of a branching epithelium 236
                branching morphogenesis of an epithelial tube 198
                  epithelial tube branching involved in lung morphogenesis 40
                    bud dilation involved in lung branching + 1
                    bud elongation involved in lung branching 7
                    bud outgrowth involved in lung branching + 4
                    dichotomous subdivision of terminal units involved in lung branching + 3
                    lateral sprouting involved in lung morphogenesis 2
                    negative regulation of branching involved in lung morphogenesis + 1
                    positive regulation of branching involved in lung morphogenesis + 3
                    primary lung bud formation + 5
                    regulation of branching involved in lung morphogenesis + 7
paths to the root