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ONTOLOGY REPORT - ANNOTATIONS


Term:SMAD protein signal transduction
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Accession:GO:0060395 term browser browse the term
Definition:The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.


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SMAD protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Afp alpha-fetoprotein JBrowse link 14 19,141,755 19,159,919 RGD:1624291
RGD:1600115
G Atoh8 atonal bHLH transcription factor 8 JBrowse link 4 100,067,341 100,099,517 RGD:1624291
G Bmp10 bone morphogenetic protein 10 JBrowse link 4 119,224,906 119,230,534 RGD:13792537
G Bmp15 bone morphogenetic protein 15 JBrowse link X 17,016,831 17,021,894 RGD:13792537
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
RGD:13792537
RGD:1600115
G Bmp3 bone morphogenetic protein 3 JBrowse link 14 12,362,912 12,387,572 RGD:13792537
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:13792537
RGD:1600115
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:13792537
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:1624291
RGD:13792537
RGD:1600115
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
RGD:13792537
G Bmp8a bone morphogenetic protein 8a JBrowse link 5 141,007,462 141,033,511 RGD:13792537
G Bmp8b bone morphogenetic protein 8b JBrowse link 5 140,803,387 140,821,104 RGD:13792537
G Btbd11 BTB domain containing 11 JBrowse link 7 24,041,194 24,314,418 RGD:1624291
RGD:13792537
G Cers1 ceramide synthase 1 JBrowse link 16 20,845,580 20,860,789 RGD:13792537
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 JBrowse link X 72,128,996 72,133,692 RGD:1624291
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:1624291
G Gata4 GATA binding protein 4 JBrowse link 15 46,386,703 46,458,679 RGD:1624291
G Gdf1 growth differentiation factor 1 JBrowse link 16 20,845,580 20,860,789 RGD:13792537
G Gdf10 growth differentiation factor 10 JBrowse link 16 10,250,508 10,262,383 RGD:13792537
G Gdf11 growth differentiation factor 11 JBrowse link 7 3,306,863 3,315,856 RGD:1624291
RGD:13792537
RGD:1600115
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:1600115
RGD:13792537
RGD:1624291
G Gdf2 growth differentiation factor 2 JBrowse link 16 10,267,510 10,293,545 RGD:13792537
G Gdf3 growth differentiation factor 3 JBrowse link 4 155,417,667 155,422,014 RGD:13792537
G Gdf5 growth differentiation factor 5 JBrowse link 3 151,482,672 151,487,129 RGD:1624291
RGD:13792537
G Gdf6 growth differentiation factor 6 JBrowse link 5 23,056,345 23,072,666 RGD:1624291
RGD:13792537
RGD:1600115
G Gdf7 growth differentiation factor 7 JBrowse link 6 33,496,596 33,507,626 RGD:13792537
G Gdf9 growth differentiation factor 9 JBrowse link 10 38,782,519 38,793,238 RGD:13792537
G Hexa hexosaminidase subunit alpha JBrowse link 8 64,325,435 64,350,775 RGD:1624291
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link 4 66,438,390 66,625,183 RGD:1624291
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:1624291
G Hnf4a hepatocyte nuclear factor 4, alpha JBrowse link 3 159,902,441 159,965,003 RGD:1624291
RGD:1600115
G Inha inhibin subunit alpha JBrowse link 9 82,700,482 82,703,383 RGD:13792537
G Inhba inhibin subunit beta A JBrowse link 17 51,894,869 51,919,998 RGD:13792537
G Inhbb inhibin subunit beta B JBrowse link 13 35,436,532 35,442,222 RGD:13792537
G Inhbc inhibin subunit beta C JBrowse link 7 70,648,005 70,661,475 RGD:13792537
G Inhbe inhibin subunit beta E JBrowse link 7 70,641,423 70,642,848 RGD:13792537
G Jade2 jade family PHD finger 2 JBrowse link 10 37,269,132 37,315,638 RGD:1624291
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:1624291
G Lefty1 left right determination factor 1 JBrowse link 13 99,212,778 99,217,786 RGD:13792537
G Lefty2 Left-right determination factor 2 JBrowse link 13 99,173,484 99,178,037 RGD:13792537
G Lnpep leucyl and cystinyl aminopeptidase JBrowse link 1 59,289,392 59,384,540 RGD:1624291
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 JBrowse link 4 10,995,241 12,472,423 RGD:1600115
RGD:1624291
G Mir130a microRNA 130a JBrowse link 3 72,141,037 72,141,124 RGD:1624291
G Mir181c microRNA 181c JBrowse link 19 25,290,211 25,290,316 RGD:1624291
G Mir181d microRNA 181d JBrowse link 19 25,290,051 25,290,133 RGD:1624291
G Mir185 microRNA 185 JBrowse link 11 86,812,702 86,812,781 RGD:1624291
G Mir25 microRNA 25 JBrowse link 12 19,307,340 19,307,423 RGD:1624291
G Mir7-1 microRNA 7-1 JBrowse link 17 6,675,016 6,675,112 RGD:1624291
G Mstn myostatin JBrowse link 9 53,310,977 53,315,804 RGD:13792537
G Nceh1 neutral cholesterol ester hydrolase 1 JBrowse link 2 112,868,834 112,932,622 RGD:1624291
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:1624291
RGD:13792537
G Nup93 nucleoporin 93 JBrowse link 19 11,159,769 11,263,980 RGD:1624291
RGD:1600115
G Pias2 protein inhibitor of activated STAT, 2 JBrowse link 18 73,479,863 73,524,956 RGD:1624291
G Rbm14 RNA binding motif protein 14 JBrowse link 1 220,048,740 220,067,124 RGD:1624291
G Ror2 receptor tyrosine kinase-like orphan receptor 2 JBrowse link 17 11,953,552 12,134,386 RGD:1624291
G Ski SKI proto-oncogene JBrowse link 5 172,556,196 172,623,878 RGD:1624291
G Slc33a1 solute carrier family 33 member 1 JBrowse link 2 154,520,170 154,542,981 RGD:1624291
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:1624291
RGD:1600115
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:1624291
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1624291
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1600115
RGD:1624291
G Smad5 SMAD family member 5 JBrowse link 17 8,307,448 8,336,996 RGD:1624291
G Smad9 SMAD family member 9 JBrowse link 2 143,951,725 144,002,025 RGD:1624291
G Stoml1 stomatin like 1 JBrowse link 8 63,037,135 63,045,024 RGD:1624291
G Sub1 SUB1 regulator of transcription JBrowse link 2 62,019,902 62,034,704 RGD:1624291
G Tbxt T-box transcription factor T JBrowse link 1 52,887,067 52,900,691 RGD:1624291
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:1624291
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:13792537
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
RGD:13792537
RGD:1600115
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:13792537
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:1624291
RGD:1600115
G Zmiz1 zinc finger, MIZ-type containing 1 JBrowse link 16 1,749,191 1,954,633 RGD:1624291
G Zmiz2 zinc finger, MIZ-type containing 2 JBrowse link 14 86,645,875 86,662,419 RGD:1624291
negative regulation of SMAD protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccn3 cellular communication network factor 3 JBrowse link 7 94,375,134 94,382,154 RGD:1624291
RGD:1600115
G Cilp cartilage intermediate layer protein JBrowse link 8 70,760,922 70,775,891 RGD:1624291
G Fam89b family with sequence similarity 89, member B JBrowse link 1 221,085,894 221,087,449 RGD:1624291
RGD:13792537
G Pbld1 phenazine biosynthesis-like protein domain containing 1 JBrowse link 20 27,103,300 27,118,650 RGD:1624291
G Slc2a10 solute carrier family 2 member 10 JBrowse link 3 162,182,156 162,194,610 RGD:1624291
G Ucma upper zone of growth plate and cartilage matrix associated JBrowse link 17 77,252,099 77,262,301 RGD:1624291
G Veph1 ventricular zone expressed PH domain-containing 1 JBrowse link 2 157,869,383 158,156,266 RGD:1600115
RGD:1624291
positive regulation of SMAD protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:1624291
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
G Dab2 DAB adaptor protein 2 JBrowse link 2 55,747,353 55,768,848 RGD:1600115
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1624291
G Nodal nodal growth differentiation factor JBrowse link 20 31,035,729 31,044,096 RGD:1624291
G Nup93 nucleoporin 93 JBrowse link 19 11,159,769 11,263,980 RGD:1624291
RGD:1600115
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:8554355
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:1624291
G Rbpms RNA binding protein, mRNA processing factor JBrowse link 16 61,954,569 62,109,998 RGD:1624291
G RGD1307443 similar to mKIAA0319 protein JBrowse link 17 42,163,245 42,226,725 RGD:1624291
G Sh2b1 SH2B adaptor protein 1 JBrowse link 1 197,878,839 197,888,223 RGD:1624291
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1600115
RGD:1624291
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:1624291
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:1624291
regulation of SMAD protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gdf5 growth differentiation factor 5 JBrowse link 3 151,482,672 151,487,129 RGD:1624291
G Ovol2 ovo-like zinc finger 2 JBrowse link 3 138,433,990 138,464,511 RGD:1624291
G Sptbn1 spectrin, beta, non-erythrocytic 1 JBrowse link 14 114,517,839 114,700,199 RGD:1624291
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
G Tob1 transducer of ErbB-2.1 JBrowse link 10 81,913,689 81,915,727 RGD:1624291
RGD:1600115
G Wwtr1 WW domain containing transcription regulator 1 JBrowse link 2 147,577,149 147,693,033 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    signaling 7553
      signal transduction 6968
        SMAD protein signal transduction 93
          negative regulation of SMAD protein signal transduction 7
          positive regulation of SMAD protein signal transduction 16
          regulation of SMAD protein signal transduction + 28
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            cell surface receptor signaling pathway 2772
              enzyme linked receptor protein signaling pathway 956
                transmembrane receptor protein serine/threonine kinase signaling pathway 376
                  SMAD protein signal transduction 93
                    negative regulation of SMAD protein signal transduction 7
                    positive regulation of SMAD protein signal transduction 16
                    regulation of SMAD protein signal transduction + 28
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.