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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of SMAD protein signal transduction
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Accession:GO:0060390 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
Synonyms:narrow_synonym: SMAD protein import into nucleus;   regulation of SMAD protein nuclear translocation
 alt_id: GO:0007184


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regulation of SMAD protein signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdf5 growth differentiation factor 5 involved_in ISO (PMID:21976273) RGD PMID:21976273 NCBI chr 3:151,482,672...151,487,129
Ensembl chr 3:151,483,249...151,486,693
JBrowse link
G Ovol2 ovo-like zinc finger 2 involved_in ISO (MGI:6284898|PMID:28455959) RGD PMID:28455959 MGI:6284898 NCBI chr 3:138,433,990...138,464,511
Ensembl chr 3:138,433,990...138,462,063
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 acts_upstream_of_or_within ISO (MGI:2449899|PMID:12543979) RGD PMID:12543979 MGI:2449899 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:25893292)
UniProt
RGD
PMID:25893292 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tob1 transducer of ErbB-2.1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:1928565|PMID:11163184)
Ensembl
RGD
PMID:11163184 GO_REF:0000107 MGI:1928565 NCBI chr10:81,913,689...81,915,727
Ensembl chr10:81,913,689...81,915,716
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 involved_in ISO (PMID:18568018) RGD PMID:18568018 NCBI chr 2:147,577,149...147,693,033
Ensembl chr 2:147,577,089...147,693,082
JBrowse link
negative regulation of SMAD protein signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn3 cellular communication network factor 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5504324|PMID:23653360)
UniProt
RGD
PMID:23653360 GO_REF:0000024 MGI:5504324 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Cilp cartilage intermediate layer protein involved_in ISO UniProtKB:P01137 (PMID:29167509) RGD PMID:29167509 NCBI chr 8:70,760,922...70,775,891
Ensembl chr 8:70,760,922...70,775,891
JBrowse link
G Fam89b family with sequence similarity 89, member B involved_in IBA
ISO
PMID:21873635
(MGI:5486566|PMID:12646588)
RGD PMID:12646588, PMID:21873635 MGI:5486566, RGD:13792537 NCBI chr 1:221,085,894...221,087,449
Ensembl chr 1:221,085,895...221,087,449
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 involved_in ISO UniProtKB:Q9Y3F4 (PMID:23687415) RGD PMID:23687415 NCBI chr20:27,103,300...27,118,650
Ensembl chr20:27,103,317...27,117,663
JBrowse link
G Slc2a10 solute carrier family 2 member 10 acts_upstream_of_or_within ISO (PMID:16550171) RGD PMID:16550171 NCBI chr 3:162,182,156...162,194,610
Ensembl chr 3:162,181,974...162,194,804
JBrowse link
G Ucma upper zone of growth plate and cartilage matrix associated involved_in ISO MGI:5314628 (MGI:6163471|PMID:29563538) RGD PMID:29563538 MGI:6163471 NCBI chr17:77,252,099...77,262,301
Ensembl chr17:77,252,100...77,261,731
JBrowse link
G Veph1 ventricular zone expressed PH domain-containing 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:26039994)
UniProt
Ensembl
RGD
PMID:26039994 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:157,869,383...158,156,266
Ensembl chr 2:157,869,392...158,156,444
JBrowse link
positive regulation of SMAD protein signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:9389648)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9389648 GO_REF:0000024 GO_REF:0000107 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp6 bone morphogenetic protein 6 involved_in ISO (MGI:4352622|PMID:19252488) RGD PMID:19252488 MGI:4352622 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:9389648) RGD PMID:9389648 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Dab2 DAB adaptor protein 2 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Jak2 Janus kinase 2 acts_upstream_of_or_within ISO UniProtKB:Q5VV43 (PMID:28334068) RGD PMID:28334068 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Nodal nodal growth differentiation factor involved_in ISO (PMID:21741376) RGD PMID:21741376 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
G Nup93 nucleoporin 93 involved_in ISO
ISS
(PMID:26878725)
(MGI:5787706|PMID:26878725)
GO_REF:0000024
RGD
UniProt
PMID:26878725 GO_REF:0000024 MGI:5787706 NCBI chr19:11,159,769...11,263,980
Ensembl chr19:11,159,774...11,263,980
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 involved_in IMP PMID:22073128 BHF-UCL PMID:22073128 RGD:8554355 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Rbpms RNA binding protein, mRNA processing factor involved_in ISO (PMID:17099224) RGD PMID:17099224 NCBI chr16:61,954,569...62,109,998
Ensembl chr16:61,954,590...62,096,497
JBrowse link
G RGD1307443 similar to mKIAA0319 protein acts_upstream_of_or_within ISO UniProtKB:O60674|UniProtKB:Q9NRF2 (PMID:28334068) RGD PMID:28334068 NCBI chr17:42,163,245...42,226,725
Ensembl chr17:42,165,817...42,226,377
JBrowse link
G Sh2b1 SH2B adaptor protein 1 acts_upstream_of_or_within ISO UniProtKB:Q5VV43 (PMID:28334068) RGD PMID:28334068 NCBI chr 1:197,878,839...197,888,223
Ensembl chr 1:197,878,840...197,886,759
JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:2683382|PMID:14691138)
Ensembl
RGD
PMID:14691138 GO_REF:0000107 MGI:2683382 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:19366691), (PMID:29167509), (PMID:9389648)
AgBase
RGD
PMID:9389648 PMID:19366691 PMID:29167509 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISO (MGI:2683382|PMID:14691138) RGD PMID:14691138 MGI:2683382 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO (PMID:9389648) RGD PMID:9389648 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    response to stimulus 10435
      regulation of response to stimulus 3982
        regulation of signal transduction 2964
          regulation of SMAD protein signal transduction 28
            negative regulation of SMAD protein signal transduction 7
            positive regulation of SMAD protein signal transduction 16
Path 2
Term Annotations click to browse term
  biological_process 19612
    biological regulation 13584
      regulation of biological process 12857
        regulation of cellular process 12354
          signal transduction 6956
            cell surface receptor signaling pathway 2761
              enzyme linked receptor protein signaling pathway 967
                transmembrane receptor protein serine/threonine kinase signaling pathway 385
                  SMAD protein signal transduction 97
                    regulation of SMAD protein signal transduction 28
                      negative regulation of SMAD protein signal transduction 7
                      positive regulation of SMAD protein signal transduction 16
paths to the root