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ONTOLOGY REPORT - ANNOTATIONS

Term:cartilage development involved in endochondral bone morphogenesis
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Accession:GO:0060351 term browser browse the term
Definition:The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.


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cartilage development involved in endochondral bone morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta-synthase acts_upstream_of_or_within IMP (PMID:15622513) MGI PMID:15622513 NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212 		JBrowse link
G Col1a1 collagen, type I, alpha 1 acts_upstream_of_or_within IMP (PMID:18248096) MGI PMID:18248096 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col2a1 collagen, type II, alpha 1 acts_upstream_of_or_within ISO
IMP		 mandibular condylar cartilage
(PMID:11680679)
(PMID:9022054)
(PMID:8989518)		 RGD
MGI		 PMID:8989518 PMID:9022054 PMID:11680679 PMID:12924823 RGD:8661659 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within IMP (PMID:21185280), (PMID:23958822) MGI PMID:21185280 PMID:23958822 NCBI chr15:52,931,657...53,209,579
Ensembl chr15:52,927,434...53,209,555 		JBrowse link
G Ghr growth hormone receptor ISO RGD PMID:15749813 RGD:2307373 NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974 		JBrowse link
G Hoxa11 homeobox A11 acts_upstream_of_or_within IGI (PMID:14668414) MGI PMID:14668414 NCBI chr 6:52,219,086...52,222,784
Ensembl chr 6:52,219,086...52,222,790 		JBrowse link
G Hoxd11 homeobox D11 acts_upstream_of_or_within IGI (PMID:14668414) MGI PMID:14668414 NCBI chr 2:74,509,902...74,517,360
Ensembl chr 2:74,509,901...74,517,360 		JBrowse link
G Hspg2 perlecan (heparan sulfate proteoglycan 2) acts_upstream_of_or_within IMP (PMID:10545953) MGI PMID:10545953 NCBI chr 4:137,196,062...137,297,941
Ensembl chr 4:137,196,080...137,297,941 		JBrowse link
G Shox2 SHOX homeobox 2 acts_upstream_of_or_within IMP (PMID:16537395) MGI PMID:16537395 NCBI chr 3:66,879,056...66,889,104
Ensembl chr 3:66,879,060...66,889,104 		JBrowse link
G Sik3 SIK family kinase 3 acts_upstream_of_or_within IMP (PMID:22318228) MGI PMID:22318228 NCBI chr 9:45,924,099...46,135,492
Ensembl chr 9:45,924,118...46,135,492 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:114,760,213...114,796,497
Ensembl chr 5:114,760,213...114,796,482 		JBrowse link
chondrocyte development involved in endochondral bone morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 acts_upstream_of_or_within IMP (PMID:22492985) MGI PMID:22492985 NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3, neutral acts_upstream_of_or_within IMP (PMID:21788370) MGI PMID:21788370 NCBI chr 8:106,979,180...107,064,597
Ensembl chr 8:106,979,180...107,064,620 		JBrowse link
chondrocyte differentiation involved in endochondral bone morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axin2 axin 2 acts_upstream_of_or_within IMP (PMID:19623616) MGI PMID:19623616 NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609 		JBrowse link
G Ihh Indian hedgehog acts_upstream_of_or_within IMP (PMID:25639508) MGI PMID:25639508 NCBI chr 1:74,984,474...74,990,831
Ensembl chr 1:74,984,474...74,990,831 		JBrowse link
G Scube2 signal peptide, CUB domain, EGF-like 2 acts_upstream_of_or_within IMP (PMID:25639508) MGI PMID:25639508 NCBI chr 7:109,397,897...109,464,886
Ensembl chr 7:109,397,883...109,464,886 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Trip11 thyroid hormone receptor interactor 11 acts_upstream_of_or_within IMP (PMID:20089971) MGI PMID:20089971 NCBI chr12:101,800,304...101,879,463
Ensembl chr12:101,800,302...101,879,526 		JBrowse link
growth plate cartilage axis specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stc1 stanniocalcin 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr14:69,266,738...69,278,850
Ensembl chr14:69,266,687...69,279,253 		JBrowse link
growth plate cartilage chondrocyte development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col27a1 collagen, type XXVII, alpha 1 acts_upstream_of_or_within IMP (PMID:22206015) MGI PMID:22206015 NCBI chr 4:63,132,246...63,253,228
Ensembl chr 4:63,132,241...63,253,228 		JBrowse link
G Poc1a POC1 centriolar protein A acts_upstream_of_or_within IMP (PMID:26496357) MGI PMID:26496357 NCBI chr 9:106,156,177...106,227,721
Ensembl chr 9:106,158,260...106,227,720 		JBrowse link
growth plate cartilage chondrocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in IMP (PMID:18638549) MGI PMID:18638549 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983 		JBrowse link
G Ift80 intraflagellar transport 80 acts_upstream_of_or_within IMP (PMID:26098911) MGI PMID:26098911 NCBI chr 3:68,799,832...68,911,939
Ensembl chr 3:68,799,832...68,911,892 		JBrowse link
G Nppc natriuretic peptide type C involved_in IMP (MGI:2177134|PMID:11259675) UniProt PMID:11259675 MGI:2177134 NCBI chr 1:86,594,015...86,598,295
Ensembl chr 1:86,594,013...86,598,293 		JBrowse link
growth plate cartilage chondrocyte growth term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cst5 cystatin D involved_in IMP (PMID:16680148) MGI PMID:16680148 NCBI chr 2:149,247,242...149,252,217
Ensembl chr 2:149,246,977...149,252,213 		JBrowse link
G Rarg retinoic acid receptor, gamma involved_in IMP (MGI:3848572|PMID:19389355) UniProt PMID:19389355 MGI:3848572 NCBI chr15:102,143,373...102,165,891
Ensembl chr15:102,143,373...102,165,952 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 involved_in IMP (MGI:5317468|PMID:22421045) UniProt PMID:22421045 MGI:5317468 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II acts_upstream_of_or_within IMP (PMID:21420963) MGI PMID:21420963 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
growth plate cartilage chondrocyte morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Matn1 matrilin 1, cartilage matrix protein acts_upstream_of_or_within IMP (PMID:16877353) MGI PMID:16877353 NCBI chr 4:130,671,696...130,682,787
Ensembl chr 4:130,671,696...130,682,786 		JBrowse link
growth plate cartilage chondrocyte proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in IMP (PMID:18638549) MGI PMID:18638549 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983 		JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist involved_in IEP (MGI:5315688|PMID:19113921) BHF-UCL PMID:19113921 MGI:5315688 NCBI chr 4:82,799,988...82,803,388
Ensembl chr 4:82,799,988...82,803,385 		JBrowse link
G Nppc natriuretic peptide type C involved_in IMP (MGI:2177134|PMID:11259675) UniProt PMID:11259675 MGI:2177134 NCBI chr 1:86,594,015...86,598,295
Ensembl chr 1:86,594,013...86,598,293 		JBrowse link
growth plate cartilage development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen, type II, alpha 1 ISO spheno-occipital synchondrosis RGD PMID:20591638 RGD:8661256 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576 		JBrowse link
G Col9a1 collagen, type IX, alpha 1 acts_upstream_of_or_within IGI
IMP		 (PMID:18467703)
(PMID:18191556)		 MGI PMID:18191556 PMID:18467703 NCBI chr 1:24,216,670...24,291,819
Ensembl chr 1:24,216,691...24,291,765 		JBrowse link
G Comp cartilage oligomeric matrix protein acts_upstream_of_or_within IGI
IMP		 (PMID:18191556)
(PMID:17588960)
(PMID:18467703)		 MGI PMID:17588960 PMID:18191556 PMID:18467703 NCBI chr 8:70,826,186...70,834,721
Ensembl chr 8:70,826,208...70,834,716 		JBrowse link
G Fosl2 fos-like antigen 2 acts_upstream_of_or_within IMP (PMID:15509771) MGI PMID:15509771 NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186 		JBrowse link
G Ift80 intraflagellar transport 80 acts_upstream_of_or_within IMP (PMID:26098911) MGI PMID:26098911 NCBI chr 3:68,799,832...68,911,939
Ensembl chr 3:68,799,832...68,911,892 		JBrowse link
G Mmp13 matrix metallopeptidase 13 acts_upstream_of_or_within IGI (PMID:21444811) MGI PMID:21444811 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Npr2 natriuretic peptide receptor 2 involved_in IMP (PMID:23065701)
(PMID:17728275)		 MGI PMID:17728275 PMID:23065701 NCBI chr 4:43,629,015...43,651,437
Ensembl chr 4:43,631,935...43,651,244 		JBrowse link
G Rara retinoic acid receptor, alpha acts_upstream_of_or_within IGI (PMID:19389355) MGI PMID:19389355 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768 		JBrowse link
G Rarb retinoic acid receptor, beta acts_upstream_of_or_within IGI (PMID:19389355) MGI PMID:19389355 NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924 		JBrowse link
G Rarg retinoic acid receptor, gamma acts_upstream_of_or_within IGI (PMID:19389355) MGI PMID:19389355 NCBI chr15:102,143,373...102,165,891
Ensembl chr15:102,143,373...102,165,952 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II acts_upstream_of_or_within IGI (PMID:21420963) MGI PMID:21420963 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428 		JBrowse link
G Thbs1 thrombospondin 1 acts_upstream_of_or_within IMP
IGI		 (PMID:18467703) MGI PMID:18467703 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Thbs3 thrombospondin 3 acts_upstream_of_or_within IMP
IGI		 (PMID:18467703) MGI PMID:18467703 NCBI chr 3:89,122,470...89,134,148
Ensembl chr 3:89,122,487...89,134,144 		JBrowse link
G Zmpste24 zinc metallopeptidase, STE24 acts_upstream_of_or_within IMP (PMID:11923874) MGI PMID:11923874 NCBI chr 4:120,916,434...120,955,452
Ensembl chr 4:120,916,434...120,955,438 		JBrowse link
negative regulation of growth plate cartilage chondrocyte proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dspp dentin sialophosphoprotein acts_upstream_of_or_within IMP (PMID:26972716) MGI PMID:26972716 NCBI chr 5:104,318,569...104,327,993
Ensembl chr 5:104,318,578...104,327,993 		JBrowse link
regulation of growth plate cartilage chondrocyte proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 acts_upstream_of_or_within IMP (PMID:19725955) MGI PMID:19725955 NCBI chr 9:21,458,163...21,500,763
Ensembl chr 9:21,458,190...21,503,919 		JBrowse link
G Por cytochrome p450 oxidoreductase involved_in ISO positive regulation RGD
MGI		 PMID:19264869 GO_REF:0000096 MGI:4417868 RGD:2316785 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    developmental process 7369
      anatomical structure development 6841
        animal organ development 3777
          cartilage development 240
            cartilage development involved in endochondral bone morphogenesis 42
              chondrocyte differentiation involved in endochondral bone morphogenesis + 16
              growth plate cartilage development + 26
Path 2
Term Annotations click to browse term
  biological_process 28573
    developmental process 7369
      anatomical structure development 6841
        multicellular organism development 5433
          system development 4660
            skeletal system development 591
              bone development 259
                bone morphogenesis 117
                  endochondral bone morphogenesis 71
                    cartilage development involved in endochondral bone morphogenesis 42
                      chondrocyte differentiation involved in endochondral bone morphogenesis + 16
                      growth plate cartilage development + 26
paths to the root