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ONTOLOGY REPORT - ANNOTATIONS

Term:cardiac epithelial to mesenchymal transition
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Accession:GO:0060317 term browser browse the term
Definition:A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
Synonyms:exact_synonym: heart epithelial to mesenchymal transition


show annotations for term's descendants           Sort by:
cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM15 ADAM metallopeptidase domain 15 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:42,432,067...42,443,463
Ensembl chr 7:42,428,113...42,443,429 		JBrowse link
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:15,199,667...15,211,509
Ensembl chr24:15,200,291...15,212,217 		JBrowse link
G EFNA4 ephrin A4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:42,427,539...42,431,788
Ensembl chr 7:42,428,113...42,443,429 		JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 involved_in ISO (PMID:17303760) BHF-UCL PMID:17303760 NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121 		JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:64,630,656...64,646,546 JBrowse link
G HEYL hes related family bHLH transcription factor with YRPW motif like involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:3,242,738...3,257,275
Ensembl chr15:3,235,611...3,303,445 		JBrowse link
G NOTCH1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
G RTN4 reticulon 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:55,884,452...55,954,476
Ensembl chr10:55,885,125...55,936,574 		JBrowse link
G TBX3 T-box transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:11,694,885...11,709,594
Ensembl chr26:11,696,565...11,708,918 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242 		JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:57,025,096...57,220,240
Ensembl chr 6:57,025,112...57,217,121 		JBrowse link
G WNT16 Wnt family member 16 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:59,388,034...59,404,812
Ensembl chr14:59,387,846...59,396,622 		JBrowse link
G WNT2 Wnt family member 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:56,123,735...56,172,113
Ensembl chr14:56,129,248...56,172,069 		JBrowse link
endocardial cushion to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVRL1 activin A receptor like type 1 NOT|involved_in ISO (PMID:12941632) BHF-UCL PMID:12941632 NCBI chr27:3,075,373...3,090,549
Ensembl chr27:3,076,124...3,092,469 		JBrowse link
G ENG endoglin NOT|involved_in ISO (PMID:12941632) BHF-UCL PMID:12941632 NCBI chr 9:55,558,246...55,590,081
Ensembl chr 9:55,558,305...55,589,064 		JBrowse link
G HAS2 hyaluronan synthase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:20,310,946...20,342,647
Ensembl chr13:20,309,872...20,341,636 		JBrowse link
endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EFNA1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,373,197...42,381,161
Ensembl chr 7:42,373,639...42,378,946 		JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (PMID:15680351) MGI PMID:15680351 NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121 		JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:64,630,656...64,646,546 JBrowse link
epithelial to mesenchymal transition involved in cardiac fibroblast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR21 microRNA mir-21 involved_in ISO (PMID:23441172) BHF-UCL PMID:23441172 NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624 		JBrowse link
G PDCD4 programmed cell death 4 involved_in ISO PMID:23441172 BHF-UCL PMID:23441172 RGD:10400865 NCBI chr28:22,198,274...22,227,184
Ensembl chr28:22,198,322...22,226,717 		JBrowse link
G SPRY1 sprouty RTK signaling antagonist 1 involved_in ISO PMID:23441172 BHF-UCL PMID:23441172 RGD:10400865 NCBI chr19:16,969,869...16,976,573
Ensembl chr19:16,970,904...16,972,089 		JBrowse link
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 NOT|involved_in ISO (PMID:18924235) BHF-UCL PMID:18924235 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557 		JBrowse link
G ENG endoglin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:55,558,246...55,590,081
Ensembl chr 9:55,558,305...55,589,064 		JBrowse link
G FGF8 fibroblast growth factor 8 acts_upstream_of_or_within
involved_in		 IEA
ISO		 (PMID:19509466) Ensembl
BHF-UCL		 PMID:19509466 GO_REF:0000107 NCBI chr28:14,362,407...14,367,109
Ensembl chr28:14,362,109...14,367,468 		JBrowse link
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO (PMID:17303760) MGI PMID:17303760 NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121 		JBrowse link
G HEYL hes related family bHLH transcription factor with YRPW motif like acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:3,242,738...3,257,275
Ensembl chr15:3,235,611...3,303,445 		JBrowse link
G MSX1 msh homeobox 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:70,232,790...70,236,295
Ensembl chr 3:70,232,052...70,236,447 		JBrowse link
G MSX2 msh homeobox 2 acts_upstream_of_or_within ISO (PMID:18667074) MGI PMID:18667074 NCBI chr 4:38,002,724...38,007,407
Ensembl chr 4:38,002,428...38,007,407 		JBrowse link
G NOTCH1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:84,060,417...84,286,008
Ensembl chr 3:84,064,440...84,286,360 		JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:23,875,989...23,930,027
Ensembl chr 1:23,882,139...23,969,405 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:36,498,343...36,503,623
Ensembl chr24:36,498,062...36,503,628 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 acts_upstream_of_or_within
involved_in		 ISO (PMID:18663143) MGI
BHF-UCL		 PMID:18663143 NCBI chr29:1,154,132...1,156,653
Ensembl chr29:1,154,036...1,156,653 		JBrowse link
G TMEM100 transmembrane protein 100 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:30,695,711...30,701,730
Ensembl chr 9:30,696,765...30,697,169 		JBrowse link
negative regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR19A microRNA mir-19a acts_upstream_of ISO (PMID:27098600) BHF-UCL PMID:27098600 NCBI chr22:42,478,298...42,478,355
Ensembl chr22:42,478,285...42,478,366 		JBrowse link
G MIR19B-1 microRNA mir-19b-1 acts_upstream_of ISO (PMID:27098600) BHF-UCL PMID:27098600 NCBI chr22:42,478,598...42,478,656 JBrowse link
G MIR19B-2 microRNA mir-19b-2 acts_upstream_of ISO (PMID:27098600) BHF-UCL PMID:27098600 NCBI chr  X:104,895,962...104,896,025
Ensembl chr  X:104,895,962...104,896,025 		JBrowse link
G NOG noggin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:31,453,604...31,456,060 JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TGFB2 transforming growth factor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242 		JBrowse link
positive regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:3,743,257...3,818,659
Ensembl chr36:3,744,163...3,818,652 		JBrowse link
G EMP2 epithelial membrane protein 2 involved_in ISO (PMID:30773261) UniProt PMID:30773261 NCBI chr 6:32,026,908...32,060,447
Ensembl chr 6:32,026,916...32,057,693 		JBrowse link
G JAG1 jagged canonical Notch ligand 1 involved_in ISO PMID:20951801 BHF-UCL PMID:20951801 RGD:13601997 NCBI chr24:11,656,926...11,693,146
Ensembl chr24:11,657,416...11,692,199 		JBrowse link
G NOTCH1 notch receptor 1 involved_in ISO PMID:20951801 BHF-UCL PMID:20951801 RGD:13601997 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242 		JBrowse link
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TWIST1 twist family bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENG endoglin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:55,558,246...55,590,081
Ensembl chr 9:55,558,305...55,589,064 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:13,430,832...13,511,655
Ensembl chr38:13,429,148...13,510,242 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:56,191,383...56,223,042
Ensembl chr11:56,161,772...56,218,594 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:13,886,869...13,946,480
Ensembl chr23:13,889,000...13,977,636 		JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 NOT|involved_in ISO (PMID:19161227) BHF-UCL PMID:19161227 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G TGFB3 transforming growth factor beta 3 NOT|involved_in ISO (PMID:19161227) BHF-UCL PMID:19161227 NCBI chr 8:48,920,874...48,946,037
Ensembl chr 8:48,923,423...48,945,816 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22141
    developmental process 6924
      anatomical structure morphogenesis 3011
        animal organ morphogenesis 1172
          heart morphogenesis 304
            cardiac epithelial to mesenchymal transition 41
              endocardial cushion to mesenchymal transition + 7
              epithelial to mesenchymal transition involved in cardiac fibroblast development 3
              epithelial to mesenchymal transition involved in coronary vasculature morphogenesis 0
              epithelial to mesenchymal transition involved in endocardial cushion formation + 18
              negative regulation of cardiac epithelial to mesenchymal transition + 5
              positive regulation of cardiac epithelial to mesenchymal transition + 9
              regulation of cardiac epithelial to mesenchymal transition + 15
Path 2
Term Annotations click to browse term
  biological_process 22141
    developmental process 6924
      anatomical structure development 6488
        multicellular organism development 5248
          system development 4574
            circulatory system development 1376
              heart development 747
                heart morphogenesis 304
                  cardiac epithelial to mesenchymal transition 41
                    endocardial cushion to mesenchymal transition + 7
                    epithelial to mesenchymal transition involved in cardiac fibroblast development 3
                    epithelial to mesenchymal transition involved in coronary vasculature morphogenesis 0
                    epithelial to mesenchymal transition involved in endocardial cushion formation + 18
                    negative regulation of cardiac epithelial to mesenchymal transition + 5
                    positive regulation of cardiac epithelial to mesenchymal transition + 9
                    regulation of cardiac epithelial to mesenchymal transition + 15
paths to the root